STRINGSTRING
unc-40 unc-40 srx-44 srx-44 srx-43 srx-43 T09B9.1 T09B9.1 T05E12.3 T05E12.3 T04C4.1 T04C4.1 daf-16 daf-16 lin-12 lin-12 R02D5.3 R02D5.3 abl-1 abl-1 fut-1 fut-1 idi-1 idi-1 sol-2 sol-2 plx-2 plx-2 neto-1 neto-1 gly-6 gly-6 ser-1 ser-1 cex-1 cex-1 ina-1 ina-1 pat-2 pat-2 dom-3 dom-3 F40A3.3 F40A3.3 hsp-12.6 hsp-12.6 hsp-12.3 hsp-12.3 F33G12.6 F33G12.6 daf-1 daf-1 trcs-1 trcs-1 F26E4.7 F26E4.7 ehbp-1 ehbp-1 F22E5.8 F22E5.8 F22E5.6 F22E5.6 bcl-11 bcl-11 tir-1 tir-1 stg-2 stg-2 lgc-38 lgc-38 ddr-2 ddr-2 ercc-1 ercc-1 lgc-39 lgc-39 molo-1 molo-1 nmr-1 nmr-1 lgc-28 lgc-28 D2045.8 D2045.8 D2013.6 D2013.6 rig-3 rig-3 C50F4.9 C50F4.9 unc-112 unc-112 unc-93 unc-93 vps-45 vps-45 lgc-43 lgc-43 ahr-1 ahr-1 acr-9 acr-9 C40A11.7 C40A11.7 C40A11.6 C40A11.6 C40A11.3 C40A11.3 npr-1 npr-1 C37H5.14 C37H5.14 sma-6 sma-6 pat-4 pat-4 pxl-1 pxl-1 glc-4 glc-4 rap-1 rap-1 flp-21 flp-21 aha-1 aha-1 stg-1 stg-1 C17F4.8 C17F4.8 lin-18 lin-18 lgc-24 lgc-24 lgc-23 lgc-23 sol-1 sol-1 mma-1 mma-1 ril-2 ril-2 C14C10.2 C14C10.2 ced-10 ced-10 ser-7 ser-7 rap-3 rap-3 clh-5 clh-5 tol-1 tol-1 glr-1 glr-1 daf-4 daf-4 dyf-11 dyf-11 rbg-3 rbg-3 age-1 age-1 B0281.6 B0281.6 B0281.5 B0281.5 fbn-1 fbn-1 seb-2 seb-2 gbb-2 gbb-2 tph-1 tph-1 let-23 let-23 nit-1 nit-1 pat-3 pat-3 gab-1 gab-1 ZC239.5 ZC239.5 ZC239.4 ZC239.4 ZC239.16 ZC239.16 ZC239.15 ZC239.15 ZC239.14 ZC239.14 ZC239.13 ZC239.13 sdz-35 sdz-35 lgc-10 lgc-10 drag-1 drag-1 tln-1 tln-1 plx-1 plx-1 daf-2 daf-2 nipa-1 nipa-1 eat-2 eat-2 spsb-1 spsb-1 spsb-2 spsb-2 nceh-1 nceh-1 gbb-1 gbb-1 tsp-13 tsp-13 ptr-18 ptr-18 ser-4 ser-4 Y12A6A.1 Y12A6A.1 daf-38 daf-38 rme-1 rme-1 W06B4.2 W06B4.2 afd-1 afd-1 mex-1 mex-1 W02D9.2 W02D9.2 eol-1 eol-1 act-5 act-5 glt-4 glt-4 T22B11.4 T22B11.4 unc-49 unc-49
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
unc-40Unc-40 protein. (1415 aa)
srx-447TM_GPCR_Srx domain-containing protein. (322 aa)
srx-43Serpentine receptor class X-43; Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior. Belongs to the G-protein coupled receptor 1 family. (319 aa)
T09B9.1Uncharacterized protein. (431 aa)
T05E12.3BTB domain-containing protein. (261 aa)
T04C4.1Uncharacterized protein. (955 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
lin-12Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. (1429 aa)
R02D5.3Uncharacterized protein. (258 aa)
abl-1Tyrosine-protein kinase abl-1; Functions downstream of migratory protein mig-13 and is involved in Q neuroblast migration during larval development. Recruited by mig-13 to the leading edge of Q neuroblasts and their descendents to signal downstream, likely to the wve-1 pathway, and direct migration along the anteroposterior body axis. Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. (1224 aa)
fut-1Alpha-(1,3)-fucosyltransferase fut-1; Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the first GlcNAc residue (with or without alpha 1,6-linked fucose), next to the peptide chains in N-glycans. Unlike in mammals, does not require the prior action of N-acetylglucosaminyltransferase I to generate complex N-glycans. (433 aa)
idi-1Nudix hydrolase domain-containing protein. (236 aa)
sol-2Suppressor Of Lurcher movement defect. (436 aa)
plx-2Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. Probably in response to stimulation by mab-20, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons. Bel [...] (1766 aa)
neto-1NETO (NEuropilin and TOlloid-like) homolog. (368 aa)
gly-6Probable N-acetylgalactosaminyltransferase 6; Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. (618 aa)
ser-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (683 aa)
cex-1Calexcitin-1. (204 aa)
ina-1Integrin alpha ina-1; Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis. Belongs to the integrin alpha chain family. (1139 aa)
pat-2Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] (1226 aa)
dom-3Decapping nuclease dom-3; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). (393 aa)
F40A3.3Phosphatidylethanolamine-binding protein homolog F40A3.3. (226 aa)
hsp-12.6SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (110 aa)
hsp-12.3SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (109 aa)
F33G12.6PPM-type phosphatase domain-containing protein. (771 aa)
daf-1Cell surface receptor daf-1; Controls the dauer/nondauer developmental decision in a range of environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. (669 aa)
trcs-1TRansport of membrane to Cell Surface. (428 aa)
F26E4.7Uncharacterized protein. (677 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
F22E5.8BTB domain-containing protein. (276 aa)
F22E5.6BTB domain-containing protein. (225 aa)
bcl-11Mammalian BCL (B cell lymphoma) gene homologs. (694 aa)
tir-1NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa)
stg-2STarGazin (Mammalian calcium channel) homolog. (379 aa)
lgc-38Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa)
ddr-2Discoidin domain-containing receptor tyrosine kinase B; Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons. May mediate axon regeneration in association with the collagen emb-9. (797 aa)
ercc-1ERCC (DNA excision repair protein) homolog. (262 aa)
lgc-39Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (563 aa)
molo-1Uncharacterized protein. (298 aa)
nmr-1NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1025 aa)
lgc-28Neur_chan_LBD domain-containing protein. (397 aa)
D2045.8BTB domain-containing protein. (238 aa)
D2013.6GRAM domain-containing protein. (235 aa)
rig-3Neuronal immunoglobulin domain-containing protein rig-3; Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling. (487 aa)
C50F4.9Uncharacterized protein. (127 aa)
unc-112Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa)
unc-93Putative potassium channel regulatory protein unc-93; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord ; Belongs to the unc-93 family. (705 aa)
vps-45Related to yeast Vacuolar Protein Sorting factor. (547 aa)
lgc-43Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (679 aa)
ahr-1Aryl hydrocarbon receptor protein 1; Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance. (602 aa)
acr-9AcetylCholine Receptor. (534 aa)
C40A11.7BTB domain-containing protein. (220 aa)
C40A11.6BTB domain-containing protein. (218 aa)
C40A11.3BTB domain-containing protein. (231 aa)
npr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa)
C37H5.14RAI1 domain-containing protein. (322 aa)
sma-6Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (636 aa)
pat-4Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...] (466 aa)
pxl-1Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa)
glc-4Glutamate-gated ChLoride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (500 aa)
rap-1Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family. (188 aa)
flp-21FMRF-Like Peptide. (66 aa)
aha-1Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons. (453 aa)
stg-1STarGazin (Mammalian calcium channel) homolog. (366 aa)
C17F4.8BTB domain-containing protein. (207 aa)
lin-18Inactive tyrosine-protein kinase RYK; Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development. Regulates pop-1 asymmetric distribution in P7.p and its daughter cells. Plays a role in the migration of ALM neurons during embryogenesis. (583 aa)
lgc-24Neur_chan_LBD domain-containing protein. (389 aa)
lgc-23Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (403 aa)
sol-1Suppressor of lurcher protein 1; Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1. (594 aa)
mma-1Uncharacterized protein. (1058 aa)
ril-2RNAi-Induced Longevity. (677 aa)
C14C10.2Uncharacterized protein. (341 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
ser-7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
rap-3RAP homolog (Vertebrate Rap GTPase family). (205 aa)
clh-5Chloride channel protein. (797 aa)
tol-1TIR domain-containing protein. (1221 aa)
glr-1Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa)
daf-4Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (744 aa)
dyf-11Uncharacterized protein. (535 aa)
rbg-3Rab-GAP TBC domain-containing protein. (585 aa)
age-1Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa)
B0281.6BTB domain-containing protein. (212 aa)
B0281.5BTB domain-containing protein. (207 aa)
fbn-1FiBrilliN homolog. (2781 aa)
seb-2G-protein coupled receptor seb-2; Not known. Putative receptor. (522 aa)
gbb-2Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (842 aa)
tph-1BH4_AAA_HYDROXYL_2 domain-containing protein. (532 aa)
let-23Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] (1335 aa)
nit-1CN hydrolase domain-containing protein. (305 aa)
pat-3Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa)
gab-1Gamma-aminobutyric acid receptor subunit beta; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. (550 aa)
ZC239.5BTB domain-containing protein. (204 aa)
ZC239.4BTB domain-containing protein. (231 aa)
ZC239.16BTB domain-containing protein. (155 aa)
ZC239.15BTB domain-containing protein. (232 aa)
ZC239.14BTB domain-containing protein. (223 aa)
ZC239.13BTB domain-containing protein. (84 aa)
sdz-35BTB domain-containing protein. (225 aa)
lgc-10Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
drag-1RGM domain family member drag-1; Probably in association with the cell surface receptor unc-40 positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway ; Belongs to the repulsive guidance molecule (RGM) family. (408 aa)
tln-1Talin. (2553 aa)
plx-1Sema domain-containing protein. (1956 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
nipa-1NIPA1 (NonImprinted gene in Prader-Willi/Angelman syndrome region 1) homolog. (397 aa)
eat-2Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa)
spsb-1B30.2/SPRY domain-containing protein. (483 aa)
spsb-2SPSB (SPry and Socs Box) family. (243 aa)
nceh-1Neutral Cholesterol Ester Hydrolase homolog. (424 aa)
gbb-1Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (899 aa)
tsp-13Tetraspanin. (321 aa)
ptr-18SSD domain-containing protein. (895 aa)
ser-4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa)
Y12A6A.1Uncharacterized protein. (209 aa)
daf-38G-protein coupled receptor daf-38; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5. (415 aa)
rme-1Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
W06B4.2BcrAD_BadFG domain-containing protein. (521 aa)
afd-1PDZ domain-containing protein. (1660 aa)
mex-1Muscle EXcess. (494 aa)
W02D9.2Protein YIPF. (240 aa)
eol-1RAI1 domain-containing protein. (316 aa)
act-5ACTin. (375 aa)
glt-4Putative sodium-dependent excitatory amino acid transporter glt-4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D- aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. (499 aa)
T22B11.4Protein kinase domain-containing protein. (892 aa)
unc-49Ionotropic GABA receptor subunit UNC-49B.3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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