Your Input: | |
| | atn-1 | AcTiniN. (920 aa) |
| | pck-1 | PEPCK_GTP domain-containing protein. (651 aa) |
| | hgo-1 | Homogentisate 1,2-dioxygenase. (437 aa) |
| | ttn-1 | Titin homolog; Serine/threonine-protein kinase. Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity). (15188 aa) |
| | Y105C5A.24 | Protein kinase domain-containing protein. (478 aa) |
| | unc-95 | LIM domain-containing protein unc-95; Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting. Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion. (350 aa) |
| | lev-11 | Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa) |
| | chp-1 | CHORD containing protein. (321 aa) |
| | zig-9 | Ig-like domain-containing protein. (283 aa) |
| | tpi-1 | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (247 aa) |
| | ctn-1 | Alpha-CaTuliN (Catenin/vinculin related). (820 aa) |
| | gst-37 | Glutathione S-Transferase. (209 aa) |
| | arx-5 | Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa) |
| | Y39A1C.1 | Uncharacterized protein. (117 aa) |
| | bkip-1 | BK channel Interacting Protein. (69 aa) |
| | Y43F8B.2 | DUF727 domain-containing protein. (317 aa) |
| | Y45G5AM.6 | Uncharacterized protein. (352 aa) |
| | Y48G10A.3 | Uncharacterized protein. (343 aa) |
| | Y48G1C.10 | Myotubularin phosphatase domain-containing protein. (803 aa) |
| | slo-1 | Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa) |
| | gst-26 | Glutathione S-Transferase; Belongs to the GST superfamily. (209 aa) |
| | gst-27 | Glutathione S-Transferase. (209 aa) |
| | gst-28 | Glutathione S-Transferase; Belongs to the GST superfamily. (209 aa) |
| | gst-29 | Glutathione S-Transferase; Belongs to the GST superfamily. (209 aa) |
| | gst-39 | Glutathione S-Transferase. (209 aa) |
| | gst-31 | Glutathione S-Transferase; Belongs to the GST superfamily. (210 aa) |
| | gst-32 | Glutathione S-Transferase; Belongs to the GST superfamily. (209 aa) |
| | Y57G11C.3 | Putative 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (269 aa) |
| | unc-15 | Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. Belongs to the paramyosin family. (872 aa) |
| | unc-87 | Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa) |
| | unc-98 | Zinc finger protein unc-98; Probable transcription factor required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (310 aa) |
| | mlc-3 | Myosin, essential light chain. (153 aa) |
| | spon-1 | SPONdin (Extracellular matrix glycoprotein) family. (819 aa) |
| | F22F7.7 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (232 aa) |
| | oig-5 | Ig-like domain-containing protein. (164 aa) |
| | hum-8 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1279 aa) |
| | tln-1 | Talin. (2553 aa) |
| | Y71H2AM.15 | AIP3 domain-containing protein. (836 aa) |
| | src-1 | Tyrosine protein-kinase src-1; Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the A [...] (537 aa) |
| | unc-52 | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa) |
| | daf-41 | Co-chaperone protein daf-41; Co-chaperone for hsp90/daf-21. Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures. Belongs to the p23/wos2 family. (175 aa) |
| | unc-93 | Putative potassium channel regulatory protein unc-93; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord ; Belongs to the unc-93 family. (705 aa) |
| | C46G7.2 | Uncharacterized protein. (250 aa) |
| | C47B2.2 | Uncharacterized protein. (231 aa) |
| | unc-112 | Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa) |
| | set-30 | MYND-type domain-containing protein. (560 aa) |
| | frg-1 | Protein FRG1 homolog; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B (By similarity); Belongs to the FRG1 family. (274 aa) |
| | pat-3 | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa) |
| | ZK1321.4 | PDZ domain-containing protein. (429 aa) |
| | cutc-1 | Copper homeostasis protein cutC homolog; Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size; Belongs to the CutC family. (250 aa) |
| | gst-30 | Glutathione S-Transferase. (213 aa) |
| | pyk-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (515 aa) |
| | unc-22 | Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (7158 aa) |
| | ZK637.2 | Uncharacterized protein ZK637.2; Belongs to the FAM136 family. (143 aa) |
| | arrd-15 | Arrestin domain-containing protein 15. (374 aa) |
| | tnc-2 | Troponin C, isoform 2; Belongs to the troponin C family. (160 aa) |
| | gst-21 | Glutathione S-Transferase; Belongs to the GST superfamily. (231 aa) |
| | unc-27 | Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa) |
| | mel-26 | Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa) |
| | mom-4 | Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (536 aa) |
| | nmy-1 | Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | spe-15 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1219 aa) |
| | pkn-1 | Protein Kinase N (PKN) homolog. (1138 aa) |
| | F42H10.3 | LIM and SH3 domain protein F42H10.3. (335 aa) |
| | zyx-1 | Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. (647 aa) |
| | tni-1 | Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (250 aa) |
| | F42C5.9 | PH domain-containing protein; Belongs to the actin family. (552 aa) |
| | F41B4.1 | Uncharacterized protein. (342 aa) |
| | F38B2.4 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | gst-19 | Glutathione S-Transferase. (207 aa) |
| | gst-18 | Glutathione S-Transferase; Belongs to the GST superfamily. (197 aa) |
| | gst-16 | Glutathione S-Transferase. (208 aa) |
| | gst-14 | Glutathione S-Transferase. (210 aa) |
| | gst-12 | Glutathione S-Transferase. (209 aa) |
| | gst-24 | Glutathione S-Transferase. (209 aa) |
| | gst-38 | Glutathione S-Transferase. (209 aa) |
| | sup-9 | Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (329 aa) |
| | uig-1 | PH domain-containing protein. (972 aa) |
| | eva-1 | Protein eva-1; Acts as a receptor for slt-1. Required for the guidance of the AVM pioneer axon to the ventral nerve cord. Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline. Belongs to the EVA1 family. (470 aa) |
| | cpna-1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. (1107 aa) |
| | cpn-3 | Calponin-homology (CH) domain-containing protein. (142 aa) |
| | lim-8 | LIM domain family. (1099 aa) |
| | stn-2 | PDZ domain-containing protein. (515 aa) |
| | exl-1 | Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family. (238 aa) |
| | F26A3.4 | Uncharacterized protein. (226 aa) |
| | lim-9 | LIM domain family. (793 aa) |
| | F25H2.4 | MPN domain-containing protein. (196 aa) |
| | anmt-1 | Nicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism. (273 aa) |
| | scpl-1 | CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa) |
| | unc-82 | Protein kinase domain-containing protein. (1793 aa) |
| | csn-5 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] (368 aa) |
| | C04F12.8 | Uncharacterized protein. (272 aa) |
| | unc-78 | Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa) |
| | C04G6.4 | Uncharacterized protein. (418 aa) |
| | C06A12.3 | DUF727 domain-containing protein. (253 aa) |
| | unc-94 | Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa) |
| | clp-1 | Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa) |
| | tmd-2 | TropoMoDulin. (639 aa) |
| | hsp-25 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (219 aa) |
| | unc-89 | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa) |
| | viln-1 | HP domain-containing protein. (918 aa) |
| | let-502 | Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization. (1173 aa) |
| | tnt-3 | TropoNin T. (1178 aa) |
| | har-1 | Hemiasterlin resistant protein 1. (154 aa) |
| | rnf-5 | E3 ubiquitin ligase rnf-5; E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the en [...] (235 aa) |
| | cysl-1 | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. (341 aa) |
| | sax-7 | Fibronectin type-III domain-containing protein. (1331 aa) |
| | C50C3.5 | Uncharacterized calcium-binding protein C50C3.5. (189 aa) |
| | inso-1 | BTB domain-containing protein. (271 aa) |
| | bre-1 | GDP-mannose 4,6 dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds. Has a role in determining brood size. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (399 aa) |
| | C55A6.10 | Uncharacterized protein. (547 aa) |
| | D1007.4 | Uncharacterized protein. (168 aa) |
| | ttll-12 | Tubulin--tyrosine ligase-like protein 12; Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family. (662 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | D2063.1 | PKS_ER domain-containing protein; Belongs to the zinc-containing alcohol dehydrogenase family. (350 aa) |
| | glrx-3 | GLutaRedoXin. (345 aa) |
| | D2092.4 | Thioredoxin domain-containing protein. (363 aa) |
| | C25F9.2 | DNA_pol_B_2 domain-containing protein. (1523 aa) |
| | pxl-1 | Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa) |
| | pat-4 | Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...] (466 aa) |
| | dyc-1 | Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function. (887 aa) |
| | mlc-1 | Myosin regulatory light chain 1. (170 aa) |
| | unc-60 | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa) |
| | madd-2 | Uncharacterized protein. (765 aa) |
| | aipl-1 | WD_REPEATS_REGION domain-containing protein. (600 aa) |
| | cysl-2 | Bifunctional L-3-cyanoalanine synthase/cysteine synthase; Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O- acetylserine and hydrogen sulfide. By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection. Involved in fertility, growth and aging. Does not mediate surv [...] (337 aa) |
| | unc-70 | Spectrin beta chain; Belongs to the spectrin family. (2326 aa) |
| | unc-68 | Uncharacterized protein. (5202 aa) |
| | myo-3 | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa) |
| | vab-8 | Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration. (1066 aa) |
| | sodh-1 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. (349 aa) |
| | sodh-2 | Alcohol dehydrogenase 2; Belongs to the zinc-containing alcohol dehydrogenase family. (351 aa) |
| | tns-1 | Tensin homolog; Probable phosphatase which regulates axon regeneration after injury by linking the svh-2 and integrin signaling pathways. (1354 aa) |
| | zig-12 | Ig-like domain-containing protein. (197 aa) |
| | gei-15 | GEX Interacting protein. (409 aa) |
| | act-4 | Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa) |
| | M79.2 | PlsC domain-containing protein. (441 aa) |
| | gst-5 | Probable glutathione S-transferase 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Sigma family. (207 aa) |
| | gst-9 | Probable glutathione S-transferase 9; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family. (206 aa) |
| | myo-1 | Myosin-1; Muscle contraction. (1938 aa) |
| | cysl-3 | Cysteine synthase 3; Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide. Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa) |
| | sup-10 | Putative potassium channel regulatory protein sup-10; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. (332 aa) |
| | allo-1 | Allophagy receptor allo-1; Autophagy receptor, which is required for allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in early embryos. After fertilization, recruited to ubiquitin-modified paternal organelles and is required for the formation of autophagosomes around the paternal organelles. Also plays a role in the regulation of autophagy in germ cells. (402 aa) |
| | R11F4.2 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (403 aa) |
| | R31.2 | ANK_REP_REGION domain-containing protein. (489 aa) |
| | T01G9.2 | UPF0183 protein T01G9.2; Belongs to the UPF0183 family. (422 aa) |
| | ufc-1 | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm-1. The intermediate is formed via a thioester linkage (By similarity). (162 aa) |
| | T03G6.3 | Uncharacterized protein. (465 aa) |
| | act-3 | Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa) |
| | act-1 | Actin-1. (376 aa) |
| | mlp-1 | LIM zinc-binding domain-containing protein. (113 aa) |
| | aldo-1 | Fructose-bisphosphate aldolase 1. (365 aa) |
| | rsbp-1 | R-Seven Binding Protein (R7BP) homolog. (171 aa) |
| | tnt-4 | TropoNin T. (375 aa) |
| | chn-1 | C-term of Hsp70-iNteracting protein (CHIP family). (266 aa) |
| | alp-1 | ALP/Enigma encoding. (1424 aa) |
| | hip-1 | TPR_REGION domain-containing protein. (422 aa) |
| | myo-2 | Myosin-2; Muscle contraction. (1947 aa) |
| | tni-3 | Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (260 aa) |
| | pat-6 | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa) |
| | hsp-12.1 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (112 aa) |
| | set-18 | MYND-type domain-containing protein. (507 aa) |
| | mup-2 | Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (405 aa) |
| | gst-13 | Glutathione S-Transferase. (208 aa) |
| | W03C9.2 | Uncharacterized protein. (371 aa) |
| | tni-4 | Troponin I 4; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (194 aa) |
| | W03F9.1 | Zinc finger protein ZPR1 homolog. (455 aa) |
| | unc-54 | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | gst-8 | Probable glutathione S-transferase 8; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family. (206 aa) |
| | gst-7 | Probable glutathione S-transferase 7; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Sigma family. (206 aa) |
| | gst-6 | Probable glutathione S-transferase 6; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family. (206 aa) |
| | unc-96 | Uncharacterized protein. (418 aa) |
| | upb-1 | CN hydrolase domain-containing protein. (387 aa) |
| | unc-97 | LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. (348 aa) |
| | dys-1 | Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa) |
| | F15G9.1 | Uncharacterized protein F15G9.1. (279 aa) |
| | F21C10.7 | Uncharacterized protein. (2588 aa) |
| | F22B5.10 | Calcium load-activated calcium channel homolog; Calcium-selective channel required to prevent calcium stores from overfilling. (186 aa) |
| | F25H2.12 | Methyltranfer_dom domain-containing protein. (478 aa) |
| | deb-1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa) |
| | mak-1 | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (521 aa) |
| | gst-4 | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. (207 aa) |
| | gst-3 | Glutathione S-transferase 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family. (207 aa) |
| | K08E3.5 | UTP--glucose-1-phosphate uridylyltransferase. (522 aa) |
| | ate-1 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family. (485 aa) |
| | gsnl-1 | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. (475 aa) |
| | smg-8 | Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family. (873 aa) |
| | pfn-3 | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (126 aa) |
| | clik-3 | CaLponIn-liKe proteins. (202 aa) |
| | ltd-1 | LIM zinc-binding domain-containing protein. (723 aa) |
| | K01F9.2 | Uncharacterized protein. (259 aa) |
| | sgca-1 | CADG domain-containing protein. (458 aa) |
| | pfd-2 | Prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family. (141 aa) |
| | unc-23 | BAG domain-containing protein. (458 aa) |
| | cysl-4 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa) |
| | F59A7.7 | PALP domain-containing protein. (162 aa) |
| | gmd-2 | GDP-mannose 4,6 dehydratase 2; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (382 aa) |
| | gyg-1 | Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for gsy-1. (429 aa) |
| | cnb-1 | Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] (171 aa) |
| | pat-2 | Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] (1226 aa) |
| | ketn-1 | KETtiN (Drosophila actin-binding) homolog. (4963 aa) |
| | pat-10 | Paralysed Arrest at Two-fold. (161 aa) |
| | unc-60-2 | Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa) |
| | tnt-2 | TropoNin T. (428 aa) |
