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| | slc-17.2 | Uncharacterized transporter slc-17.2. (493 aa) |
| | pot-3 | POT1PC domain-containing protein. (215 aa) |
| | casy-1 | CAlSYntenin/Alcadein homolog. (984 aa) |
| | ida-1 | Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. (767 aa) |
| | glr-2 | Glutamate receptor 2; L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (977 aa) |
| | lgc-20 | Neur_chan_LBD domain-containing protein. (454 aa) |
| | rpm-1 | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] (3766 aa) |
| | cam-1 | Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...] (928 aa) |
| | dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) |
| | ced-5 | CED-5. (1781 aa) |
| | lgc-9 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa) |
| | unc-46 | Uncharacterized protein. (259 aa) |
| | lnp-1 | Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family. (346 aa) |
| | glr-1 | Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa) |
| | wsp-1 | WASP (Actin cytoskeleton modulator) homolog. (781 aa) |
| | snt-6 | C2 domain-containing protein. (373 aa) |
| | ptp-3 | Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors. (2248 aa) |
| | lin-10 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. (982 aa) |
| | sol-1 | Suppressor of lurcher protein 1; Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1. (594 aa) |
| | gar-1 | Probable muscarinic acetylcholine receptor gar-1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (713 aa) |
| | C16C2.4 | BSD domain-containing protein. (361 aa) |
| | rab-3 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa) |
| | stg-1 | STarGazin (Mammalian calcium channel) homolog. (366 aa) |
| | hop-1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa) |
| | rpy-1 | 43 kDa receptor-associated protein of the synapse homolog; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. (615 aa) |
| | ascc-1 | KH domain-containing protein. (393 aa) |
| | prmt-6 | Methyltransf_25 domain-containing protein. (252 aa) |
| | C26C6.8 | Uncharacterized protein. (273 aa) |
| | fsn-1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] (332 aa) |
| | unc-41 | Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family. (1693 aa) |
| | nrx-1 | NeuReXin related. (1725 aa) |
| | kin-32 | Inactive tyrosine-protein kinase kin-32; Has apparently no tyrosine kinase activity in vitro when expressed in mammalian cells; Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. (867 aa) |
| | tbc-7 | Rab-GAP TBC domain-containing protein. (696 aa) |
| | acr-19 | AcetylCholine Receptor. (560 aa) |
| | unc-11 | Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa) |
| | shn-1 | Protein shank; Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions. Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density. The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4. Plays a role in the regulation of the defecation cycle, and this may be in as [...] (1140 aa) |
| | rig-6 | Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior. (1196 aa) |
| | lgc-21 | Neur_chan_LBD domain-containing protein. (462 aa) |
| | sphk-1 | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). (473 aa) |
| | hen-1 | HEsitatioN behavior. (117 aa) |
| | nlg-1 | Neuroligin-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission. Belongs to the type-B carboxylesterase/lipase family. (847 aa) |
| | nab-1 | NeurABin. (721 aa) |
| | mak-2 | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (366 aa) |
| | gale-1 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (349 aa) |
| | ced-3 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa) |
| | cho-1 | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. (576 aa) |
| | nep-3 | NEPrilysin metallopeptidase family. (634 aa) |
| | srh-18 | Serpentine Receptor, class H. (329 aa) |
| | dop-4 | Dopamine receptor 4; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. (517 aa) |
| | unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) |
| | rig-3 | Neuronal immunoglobulin domain-containing protein rig-3; Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling. (487 aa) |
| | cebp-1 | C/EBP (CCAAT/enhancer-binding protein) homolog. (319 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | acr-11 | AcetylCholine Receptor. (461 aa) |
| | F01D5.1 | Uncharacterized protein. (178 aa) |
| | F01D5.2 | Uncharacterized protein. (133 aa) |
| | F01D5.3 | Uncharacterized protein. (132 aa) |
| | F01D5.5 | Uncharacterized protein. (165 aa) |
| | lgc-36 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (536 aa) |
| | srsx-31 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (308 aa) |
| | glo-4 | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa) |
| | nmr-1 | NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1025 aa) |
| | lev-1 | Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa) |
| | molo-1 | Uncharacterized protein. (298 aa) |
| | emb-27 | Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (655 aa) |
| | mig-10 | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa) |
| | unc-122 | Olfactomedin-like domain-containing protein. (568 aa) |
| | lgc-38 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa) |
| | stg-2 | STarGazin (Mammalian calcium channel) homolog. (379 aa) |
| | ins-1 | IlGF domain-containing protein. (109 aa) |
| | git-1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa) |
| | lgc-22 | ShKT domain-containing protein. (445 aa) |
| | F17C11.22 | DB domain-containing protein. (233 aa) |
| | nep-6 | NEPrilysin metallopeptidase family. (726 aa) |
| | nep-7 | NEPrilysin metallopeptidase family. (481 aa) |
| | nep-8 | Peptidase_M13 domain-containing protein. (686 aa) |
| | nep-9 | NEPrilysin metallopeptidase family. (700 aa) |
| | nep-10 | NEPrilysin metallopeptidase family. (711 aa) |
| | lgc-4 | Ligand-gated ion channel 4; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (635 aa) |
| | mltn-9 | MLt-TeN (Mlt-10) related. (749 aa) |
| | mltn-10 | MLt-TeN (Mlt-10) related. (607 aa) |
| | F20D1.1 | Uncharacterized protein. (166 aa) |
| | lgc-31 | Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (675 aa) |
| | unc-38 | Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa) |
| | evl-20 | ADP-ribosylation factor-like protein 2; GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics. (184 aa) |
| | egl-1 | Programmed cell death activator egl-1; Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9. Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced- 9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis. Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron du [...] (106 aa) |
| | F23C8.13 | PDZ domain-containing protein. (244 aa) |
| | acr-15 | AcetylCholine Receptor. (479 aa) |
| | lhfp-4 | Lipoma Hmgic (HMGIC) Fusion Partner-like homolog. (229 aa) |
| | let-413 | Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] (699 aa) |
| | acr-21 | AcetylCholine Receptor. (635 aa) |
| | F28A10.5 | Methyltransf_21 domain-containing protein. (293 aa) |
| | acr-18 | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (510 aa) |
| | col-99 | Putative cuticle collagen 99; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity). (735 aa) |
| | gras-1 | PDZ domain-containing protein. (245 aa) |
| | snt-1 | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa) |
| | dlk-1 | Mitogen-activated protein kinase kinase kinase dlk-1; Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4. Has a role in axonal regrowth following injury and synaptogenesis. Also promotes tubulin post-translational modifications that protect microtubules. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis, and may also have a role in intraflagellar transport in cilia. Plays a role in the formation of muscle connections, also called mu [...] (928 aa) |
| | syx-3 | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). (306 aa) |
| | syd-1 | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. (987 aa) |
| | F35H10.10 | G_PROTEIN_RECEP_F3_4 domain-containing protein; Belongs to the G-protein coupled receptor 3 family. (1404 aa) |
| | sel-12 | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa) |
| | rbf-1 | Rabphilin-1; Rab-3 effector. (1106 aa) |
| | elp-1 | Echinoderm microtubule-associated protein-like elp-1; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. (891 aa) |
| | F38C2.4 | Methyltransf_21 domain-containing protein. (275 aa) |
| | add-1 | Adducin-related protein 1; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. (732 aa) |
| | nep-13 | NEPrilysin metallopeptidase family. (732 aa) |
| | nipi-4 | Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family. (396 aa) |
| | F41C6.4 | Uncharacterized protein. (393 aa) |
| | F41H10.4 | Uncharacterized protein. (575 aa) |
| | elks-1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. (836 aa) |
| | sph-1 | MARVEL domain-containing protein. (227 aa) |
| | snt-2 | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa) |
| | cla-1 | Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa) |
| | mgl-2 | G_PROTEIN_RECEP_F3_4 domain-containing protein. (1035 aa) |
| | lgc-11 | Acetylcholine receptor (51.1 kD) (Acr-22); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (434 aa) |
| | syx-2 | Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (299 aa) |
| | swip-10 | Lactamase_B domain-containing protein. (421 aa) |
| | gpa-5 | Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (385 aa) |
| | madd-4 | Protein madd-4; Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1. Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms. In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis. The unc-40 cor [...] (1045 aa) |
| | fig-1 | Uncharacterized protein. (2892 aa) |
| | acr-17 | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa) |
| | spd-5 | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. (1198 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | clr-1 | Receptor-type tyrosine-protein phosphatase; Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of [...] (1444 aa) |
| | add-2 | Adducin-related protein 2; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network; Belongs to the aldolase class II family. Adducin subfamily. (611 aa) |
| | ric-7 | Uncharacterized protein. (709 aa) |
| | lgc-30 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (529 aa) |
| | nsy-1 | Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa) |
| | sam-4 | Uncharacterized protein. (240 aa) |
| | syd-2 | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. (1139 aa) |
| | frm-3 | FERM domain-containing protein. (1091 aa) |
| | tbh-1 | Tyramine beta-hydroxylase; Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (657 aa) |
| | kcc-2 | K+/Cl-Cotransporter. (1129 aa) |
| | lin-33 | Uncharacterized protein. (243 aa) |
| | exp-1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. (539 aa) |
| | unc-26 | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa) |
| | magi-1 | MAGI (Membrane Associated Guanylate kinase Inverted) homolog. (1054 aa) |
| | syg-1 | Synaptogenesis protein syg-1; Cell adhesion protein. Involved in synapse formation in the HSNL egg-laying motor neuron. Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination. Also required for F- actin assembly at the synaptic region and for axon branch formation. (730 aa) |
| | nep-18 | NEPrilysin metallopeptidase family. (701 aa) |
| | dnj-14 | J domain-containing protein. (217 aa) |
| | cpx-2 | ComPleXin (Synaptic protein) homolog. (87 aa) |
| | neto-1 | NETO (NEuropilin and TOlloid-like) homolog. (368 aa) |
| | acr-5 | Acetylcholine receptor subunit alpha-type acr-5; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (598 aa) |
| | K06H6.2 | Methyltransf_21 domain-containing protein. (288 aa) |
| | glr-3 | GLutamate Receptor family (AMPA). (836 aa) |
| | vglu-2 | MFS domain-containing protein. (573 aa) |
| | unc-43 | Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...] (681 aa) |
| | tom-1 | LLGL domain-containing protein. (1255 aa) |
| | pitp-1 | DDHD domain-containing protein. (1034 aa) |
| | snf-6 | Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...] (714 aa) |
| | bris-1 | SEC7 domain-containing protein. (640 aa) |
| | acr-12 | Nicotinic acetylcholine receptor-like subunit ACR-12. (573 aa) |
| | cnk-1 | Connector enhancer of kinase suppressor of ras; Non-essential component of the Ras signaling pathway. (801 aa) |
| | acr-10 | AcetylCholine Receptor. (557 aa) |
| | R05A10.8 | Methyltransf_21 domain-containing protein. (280 aa) |
| | unc-116 | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. (815 aa) |
| | osm-8 | Osmotic avoidance abnormal protein 8; Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23. (331 aa) |
| | oig-4 | Immunoglobulin domain-containing protein oig-4; Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation. (155 aa) |
| | lgc-12 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (428 aa) |
| | mfsd-6 | MFS_1_like domain-containing protein. (630 aa) |
| | pde-4 | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. (674 aa) |
| | dpy-23 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa) |
| | syx-4 | Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa) |
| | nmr-2 | NMDA-type ionotropic glutamate receptor NMR-2. (990 aa) |
| | lgc-13 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (399 aa) |
| | lgc-14 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (400 aa) |
| | lgc-15 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (399 aa) |
| | lgc-16 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (401 aa) |
| | lgc-17 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (401 aa) |
| | lgc-18 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (399 aa) |
| | unc-2 | EF-hand domain-containing protein. (2171 aa) |
| | unc-57 | Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses. (381 aa) |
| | clic-1 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa) |
| | lgc-1 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (371 aa) |
| | nep-19 | NEPrilysin metallopeptidase family. (743 aa) |
| | nep-20 | NEPrilysin metallopeptidase family. (834 aa) |
| | clh-4 | Chloride channel protein. (1085 aa) |
| | moc-1 | Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (435 aa) |
| | vglu-3 | Potential vesicular glutamate transporter vglu-3. (544 aa) |
| | ced-9 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa) |
| | sng-1 | Synaptogyrin homolog 1; Belongs to the synaptogyrin family. (247 aa) |
| | unc-29 | Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa) |
| | acr-7 | Acetylcholine receptor subunit alpha-type acr-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (538 aa) |
| | cni-1 | Protein cornichon homolog 1; Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses. (145 aa) |
| | unc-10 | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] (1563 aa) |
| | snt-7 | C2 domain-containing protein. (416 aa) |
| | gars-1 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family. (742 aa) |
| | snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) |
| | T12C9.7 | CYCLIN domain-containing protein; Belongs to the cyclin family. (400 aa) |
| | T14E8.2 | Uncharacterized protein. (244 aa) |
| | dop-3 | Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1. (607 aa) |
| | apa-2 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa) |
| | unc-47 | Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family. (486 aa) |
| | unc-49 | Ionotropic GABA receptor subunit UNC-49B.3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa) |
| | hlb-1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. (1004 aa) |
| | ppm-2 | Probable protein phosphatase 2C T23F11.1. (356 aa) |
| | dat-1 | Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. (615 aa) |
| | snt-4 | SyNapTotagmin. (381 aa) |
| | act-5 | ACTin. (375 aa) |
| | cdk-5 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa) |
| | hic-1 | Uncharacterized protein. (167 aa) |
| | ccb-1 | GuKc domain-containing protein. (526 aa) |
| | moc-2 | MoCF_biosynth domain-containing protein. (168 aa) |
| | W01A11.7 | Uncharacterized protein. (186 aa) |
| | cat-1 | MFS domain-containing protein. (553 aa) |
| | kel-8 | Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1. (727 aa) |
| | W03A5.6 | Uncharacterized protein. (612 aa) |
| | ace-1 | Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine. (620 aa) |
| | apd-3 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa) |
| | lgc-19 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (400 aa) |
| | lev-10 | LEV-10A protein. (906 aa) |
| | pinn-1 | Peptidyl-prolyl cis-trans isomerase. (161 aa) |
| | unc-63 | Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa) |
| | lgc-55 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (538 aa) |
| | itsn-1 | ITSN (Intersectin) family. (1087 aa) |
| | nep-23 | NEPrilysin metallopeptidase family. (714 aa) |
| | nep-24 | NEPrilysin metallopeptidase family. (567 aa) |
| | daf-28 | Uncharacterized protein. (97 aa) |
| | ric-4 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa) |
| | unc-25 | Glutamic acid decarboxylase. (508 aa) |
| | snn-1 | ATP-grasp domain-containing protein. (474 aa) |
| | rimb-1 | RIM Binding protein. (1276 aa) |
| | Y39F10A.3 | Methyltransf_21 domain-containing protein. (309 aa) |
| | Y39G8B.7 | Uncharacterized protein. (179 aa) |
| | Y40H7A.4 | Methyltransf_21 domain-containing protein. (291 aa) |
| | sup-1 | Protein SUP-1; May be involved in trafficking or stabilization of the vesicular acetylcholine transporter unc-17. (103 aa) |
| | ace-2 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (629 aa) |
| | zip-4 | BZIP domain-containing protein. (318 aa) |
| | sorb-1 | Sorbin and SH3 domain-containing protein 1 homolog; Required for organization of sarcomeres in body wall muscles and for maintaining normal mitochondrial position in myocytes. (1005 aa) |
| | lgc-29 | Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (398 aa) |
| | lgc-35 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa) |
| | eat-2 | Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa) |
| | ace-3 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (607 aa) |
| | slo-1 | Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa) |
| | strd-1 | STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...] (388 aa) |
| | rsy-1 | Regulator of SYnapse formation. (589 aa) |
| | lad-2 | Immunoglobulin domain-containing protein Y54G2A.25. (1187 aa) |
| | Y55F3AM.11 | Methyltranfer_dom domain-containing protein. (323 aa) |
| | arl-8 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa) |
| | Y57G11C.22 | Uncharacterized protein. (444 aa) |
| | Y67D8C.22 | Uncharacterized protein. (225 aa) |
| | acr-25 | AcetylCholine Receptor. (544 aa) |
| | cpx-1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. (143 aa) |
| | acr-24 | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (578 aa) |
| | lgc-27 | Neur_chan_LBD domain-containing protein. (428 aa) |
| | snt-3 | SyNapTotagmin. (284 aa) |
| | aex-6 | Rab27. (215 aa) |
| | ZC262.7 | Uncharacterized protein. (171 aa) |
| | unc-17 | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa) |
| | cha-1 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. (627 aa) |
| | gab-1 | Gamma-aminobutyric acid receptor subunit beta; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. (550 aa) |
| | lgc-37 | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa) |
| | unc-16 | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa) |
| | nep-25 | Peptidase_M13 domain-containing protein. (515 aa) |
| | ehs-1 | Eps15 (Endocytosis protein) Homologous Sequence. (796 aa) |
| | ptr-23 | SSD domain-containing protein. (983 aa) |
| | eat-4 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa) |
| | spe-4 | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa) |
| | unc-13 | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa) |
| | ZK643.6 | Uncharacterized protein ZK643.6. (244 aa) |
| | unc-31 | Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa) |
| | acr-6 | AcetylCholine Receptor. (551 aa) |
