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| tra-2 | Sex-determining transformer protein 2; Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also requ [...] (1475 aa) | ||||
| anc-1 | Nuclear anchorage protein 1; Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron. Belongs to the nesprin family. (8545 aa) | ||||
| hpo-40 | Uncharacterized protein. (782 aa) | ||||
| cnx-1 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa) | ||||
| pdhk-2 | Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. (401 aa) | ||||
| ZK185.4 | Uncharacterized protein. (281 aa) | ||||
| mut-7 | Exonuclease mut-7; Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers. (910 aa) | ||||
| ZK1098.3 | Uncharacterized protein ZK1098.3. (784 aa) | ||||
| rde-8 | RNase_Zc3h12a domain-containing protein. (339 aa) | ||||
| ubxn-2 | UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling [...] (301 aa) | ||||
| egrh-3 | EGR (Early Growth factor Response factor) Homolog. (320 aa) | ||||
| pkd-2 | Polycystin-2; Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior. (716 aa) | ||||
| sut-2 | Zinc finger CCCH domain-containing protein 14. (740 aa) | ||||
| Y59E9AL.6 | Uncharacterized protein. (214 aa) | ||||
| Y57G11C.23 | MFS domain-containing protein. (529 aa) | ||||
| egrh-2 | EGR (Early Growth factor Response factor) Homolog. (294 aa) | ||||
| wee-1.3 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (677 aa) | ||||
| cccp-1 | CARD domain-containing protein. (743 aa) | ||||
| haf-6 | HAlF transporter (PGP related). (668 aa) | ||||
| obr-1 | Oxysterol-binding protein; Belongs to the OSBP family. (842 aa) | ||||
| Y41C4A.11 | LITAF domain-containing protein. (101 aa) | ||||
| Y40H7A.11 | LITAF domain-containing protein. (124 aa) | ||||
| Y39B6A.25 | Tudor domain-containing protein. (542 aa) | ||||
| Y38F1A.8 | Uncharacterized protein. (303 aa) | ||||
| smut-1 | Synthetic MUTator. (520 aa) | ||||
| npp-13 | Nuclear pore protein. (787 aa) | ||||
| Y37D8A.8 | LITAF domain-containing protein. (130 aa) | ||||
| Y37D8A.6 | LITAF domain-containing protein. (132 aa) | ||||
| Y23H5A.3 | Uncharacterized protein. (307 aa) | ||||
| Y22D7AL.15 | LITAF domain-containing protein. (152 aa) | ||||
| Y18H1A.15 | Uncharacterized protein. (654 aa) | ||||
| Y11D7A.9 | Uncharacterized protein. (297 aa) | ||||
| rhy-1 | Regulator of hypoxia-inducible factor 1; Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1- independent manner. Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis. Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation. Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis. (502 aa) | ||||
| oac-54 | Acyl_transf_3 domain-containing protein. (477 aa) | ||||
| lbp-5 | Fatty acid-binding protein homolog 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (136 aa) | ||||
| T28C6.8 | Uncharacterized protein. (119 aa) | ||||
| dyrb-1 | Dynein light chain roadblock; Belongs to the GAMAD family. (95 aa) | ||||
| T23B3.5 | Uncharacterized protein. (211 aa) | ||||
| T23B12.5 | Uncharacterized protein. (224 aa) | ||||
| erh-1 | Enhancer of rudimentary homolog; May have a role in the cell cycle. (103 aa) | ||||
| rund-1 | RUN domain-containing protein. (549 aa) | ||||
| fem-2 | Protein phosphatase fem-2; Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin- dependent protein kinase unc-43/CAMKII in vitro. Involved in the regulation of sex determination. Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes. Promotes apoptosis. Belongs to the PP2C family. (449 aa) | ||||
| cav-1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa) | ||||
| daf-9 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] (572 aa) | ||||
| cni-1 | Protein cornichon homolog 1; Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses. (145 aa) | ||||
| ced-9 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa) | ||||
| unc-69 | Uncharacterized protein. (176 aa) | ||||
| vps-53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. (798 aa) | ||||
| lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa) | ||||
| T02E1.7 | Uncharacterized protein T02E1.7; Belongs to the SURF4 family. (269 aa) | ||||
| mut-15 | MUTator. (541 aa) | ||||
| syx-4 | Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa) | ||||
| sir-2.1 | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] (607 aa) | ||||
| cdc-42 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa) | ||||
| R02D5.7 | Uncharacterized protein. (149 aa) | ||||
| osm-3 | Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport. (699 aa) | ||||
| srf-3 | UDP-galactose/UDP-N-acetylglucosamine transporter srf-3; Acts as a transporter of both UDP-galactose and UDP-N- acetylglucosamine into the Golgi lumen. (368 aa) | ||||
| gly-14 | UDP-N-acetylglucosamine:a-3-D-mannoside b-1,2-N-acetylglucosaminyltransferase I. (437 aa) | ||||
| cid-1 | 4Fe-4S ferredoxin-type domain-containing protein. (1425 aa) | ||||
| ogt-1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase; Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. (1151 aa) | ||||
| mut-2 | NTP_transf_2 domain-containing protein. (441 aa) | ||||
| fbf-1 | Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa) | ||||
| amph-1 | AMPHiphysin homolog. (461 aa) | ||||
| rde-12 | DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. (959 aa) | ||||
| clu-1 | Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria; Belongs to the CLU family. (1247 aa) | ||||
| unc-108 | Uncharacterized protein. (223 aa) | ||||
| rsd-2 | RSD-2 domain-containing protein. (1319 aa) | ||||
| gly-12 | UDP-N-acetylglucosamine:a-3-D-mannoside b-1,2-N-acetylglucosaminyltransferase I. (543 aa) | ||||
| ubxn-3 | UBX domain-containing protein 3; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. (613 aa) | ||||
| smg-4 | Smg4_UPF3 domain-containing protein. (368 aa) | ||||
| cyld-1 | USP domain-containing protein. (1144 aa) | ||||
| srh-241 | Serpentine Receptor, class H. (335 aa) | ||||
| srh-243 | Serpentine Receptor, class H. (337 aa) | ||||
| srh-186 | Serpentine Receptor, class H. (329 aa) | ||||
| sel-12 | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa) | ||||
| F35G12.11 | Enhancer of rudimentary homolog; May have a role in the cell cycle. (113 aa) | ||||
| F32E10.5 | Uncharacterized protein. (549 aa) | ||||
| srh-245 | Serpentine Receptor, class H. (330 aa) | ||||
| F30A10.12 | Uncharacterized protein. (143 aa) | ||||
| rrf-1 | RNA-dependent RNA polymerase Family. (1601 aa) | ||||
| cup-2 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa) | ||||
| ubxn-1 | UBX domain-containing protein 1; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. (299 aa) | ||||
| dpy-19 | C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...] (683 aa) | ||||
| F21F3.7 | Uncharacterized protein. (168 aa) | ||||
| rde-2 | Uncharacterized protein. (578 aa) | ||||
| pid-1 | 21U-RNA biogenesis factor pid-1; Plays a role in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing. (169 aa) | ||||
| F11G11.5 | Uncharacterized protein. (223 aa) | ||||
| F11A5.4 | Uncharacterized protein. (203 aa) | ||||
| F11A5.3 | Uncharacterized protein. (201 aa) | ||||
| sel-2 | Putative neurobeachin homolog; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells. (2507 aa) | ||||
| vps-52 | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family. (702 aa) | ||||
| tofu-6 | Embryonic developmental protein tofu-6; Required maternally for early embryonic cell divisions. May have a role in DNA replication. (367 aa) | ||||
| E03H12.5 | Uncharacterized protein. (210 aa) | ||||
| sft-4 | Surfeit locus protein 4 homolog; Belongs to the SURF4 family. (277 aa) | ||||
| ced-3 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa) | ||||
| hsp-90 | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa) | ||||
| C41G7.6 | Uncharacterized protein. (219 aa) | ||||
| ced-4 | Cell death protein 4; Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1. May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway. Regulates CEP neuron apoptosis in response to high Al(3+) levels. During male tail morphogenesis, promotes apoptosis of the tail-spike cell [...] (571 aa) | ||||
| C35D10.13 | Twenty-One u (U) antagoniST. (142 aa) | ||||
| ntp-1 | Nucleoside-triphosphatase ntp-1; Seems to be able to hydrolyze CTP, ATP and UTP. (543 aa) | ||||
| cytb-5.1 | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (134 aa) | ||||
| ubc-23 | UAS domain-containing protein. (395 aa) | ||||
| egrh-1 | EGR (Early Growth factor Response factor) Homolog. (461 aa) | ||||
| C25A8.2 | Uncharacterized protein. (149 aa) | ||||
| spas-1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. (512 aa) | ||||
| ooc-5 | Torsin-like protein; May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins; Belongs to the ClpA/ClpB family. Torsin subfamily. (356 aa) | ||||
| osm-9 | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (937 aa) | ||||
| vps-33.1 | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate lat [...] (603 aa) | ||||
| B0348.1 | LITAF domain-containing protein. (87 aa) | ||||
| B0348.2 | LITAF domain-containing protein. (86 aa) | ||||
| mut-16 | MUTator. (1054 aa) | ||||
| gly-13 | Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans (By similarity); Belongs to the glycosyltransferase 13 family. (449 aa) | ||||
| unc-76 | Uncharacterized protein. (388 aa) | ||||
| tsp-17 | Tetraspanin-17; Protects dopaminergic neurons against oxidative stress- induced neurodegeneration. May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity. Also plays a role in modulating behaviors linked to dopamine signaling. Confers protection against oxidative stress in the whole body. (312 aa) | ||||
| C02F5.10 | Uncharacterized protein C02F5.10. (145 aa) | ||||
| henn-1 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa) | ||||
| srh-244 | Serpentine Receptor, class H. (336 aa) | ||||
| cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa) | ||||
| C06A5.3 | PWWP domain-containing protein. (783 aa) | ||||
| C06A5.6 | Uncharacterized protein. (691 aa) | ||||
| glr-1 | Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa) | ||||
| C08E8.1 | LITAF domain-containing protein. (102 aa) | ||||
| dgk-1 | Diacylglycerol kinase. (952 aa) | ||||
| mut-14 | MUTator; Belongs to the DEAD box helicase family. (528 aa) | ||||
| C18B2.4 | GRAM domain-containing protein. (296 aa) | ||||