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| | ZK643.6 | Uncharacterized protein ZK643.6. (244 aa) |
| | prmt-6 | Methyltransf_25 domain-containing protein. (252 aa) |
| | fsn-1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] (332 aa) |
| | unc-41 | Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family. (1693 aa) |
| | nrx-1 | NeuReXin related. (1725 aa) |
| | unc-11 | Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa) |
| | sphk-1 | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). (473 aa) |
| | hen-1 | HEsitatioN behavior. (117 aa) |
| | nab-1 | NeurABin. (721 aa) |
| | ced-3 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa) |
| | cho-1 | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. (576 aa) |
| | nep-3 | NEPrilysin metallopeptidase family. (634 aa) |
| | unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | cla-1 | Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa) |
| | snt-2 | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa) |
| | sph-1 | MARVEL domain-containing protein. (227 aa) |
| | F01D5.1 | Uncharacterized protein. (178 aa) |
| | elks-1 | Mammalian ELKS/CAST/ERC/Rab6 interacting protein homolog. (836 aa) |
| | F41C6.4 | Uncharacterized protein. (393 aa) |
| | nep-13 | NEPrilysin metallopeptidase family. (732 aa) |
| | F38C2.4 | Methyltransf_21 domain-containing protein. (275 aa) |
| | rbf-1 | Rabphilin-1; Rab-3 effector. (1106 aa) |
| | syd-1 | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. (987 aa) |
| | syx-3 | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). (306 aa) |
| | snt-1 | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa) |
| | F28A10.5 | Methyltransf_21 domain-containing protein. (293 aa) |
| | egl-1 | Programmed cell death activator egl-1; Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9. Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced- 9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis. Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron du [...] (106 aa) |
| | F20D1.1 | Uncharacterized protein. (166 aa) |
| | mltn-10 | MLt-TeN (Mlt-10) related. (607 aa) |
| | mltn-9 | MLt-TeN (Mlt-10) related. (749 aa) |
| | nep-10 | NEPrilysin metallopeptidase family. (711 aa) |
| | nep-9 | NEPrilysin metallopeptidase family. (700 aa) |
| | nep-8 | Peptidase_M13 domain-containing protein. (686 aa) |
| | nep-7 | NEPrilysin metallopeptidase family. (481 aa) |
| | nep-6 | NEPrilysin metallopeptidase family. (726 aa) |
| | git-1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa) |
| | mig-10 | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa) |
| | F01D5.5 | Uncharacterized protein. (165 aa) |
| | F01D5.3 | Uncharacterized protein. (132 aa) |
| | F01D5.2 | Uncharacterized protein. (133 aa) |
| | dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) |
| | rpm-1 | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] (3766 aa) |
| | cpx-2 | ComPleXin (Synaptic protein) homolog. (87 aa) |
| | dnj-14 | J domain-containing protein. (217 aa) |
| | nep-18 | NEPrilysin metallopeptidase family. (701 aa) |
| | unc-26 | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa) |
| | K06H6.2 | Methyltransf_21 domain-containing protein. (288 aa) |
| | vglu-2 | MFS domain-containing protein. (573 aa) |
| | R05A10.8 | Methyltransf_21 domain-containing protein. (280 aa) |
| | osm-8 | Osmotic avoidance abnormal protein 8; Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23. (331 aa) |
| | mfsd-6 | MFS_1_like domain-containing protein. (630 aa) |
| | dpy-23 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa) |
| | syx-4 | Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa) |
| | unc-2 | EF-hand domain-containing protein. (2171 aa) |
| | unc-57 | Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses. (381 aa) |
| | clic-1 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa) |
| | nep-19 | NEPrilysin metallopeptidase family. (743 aa) |
| | nep-20 | NEPrilysin metallopeptidase family. (834 aa) |
| | vglu-3 | Potential vesicular glutamate transporter vglu-3. (544 aa) |
| | ced-9 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa) |
| | sng-1 | Synaptogyrin homolog 1; Belongs to the synaptogyrin family. (247 aa) |
| | unc-10 | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] (1563 aa) |
| | snt-7 | C2 domain-containing protein. (416 aa) |
| | snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) |
| | T14E8.2 | Uncharacterized protein. (244 aa) |
| | dop-3 | Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1. (607 aa) |
| | apa-2 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa) |
| | unc-47 | Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family. (486 aa) |
| | hlb-1 | Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. (1004 aa) |
| | ppm-2 | Probable protein phosphatase 2C T23F11.1. (356 aa) |
| | dat-1 | Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. (615 aa) |
| | hic-1 | Uncharacterized protein. (167 aa) |
| | ccb-1 | GuKc domain-containing protein. (526 aa) |
| | cat-1 | MFS domain-containing protein. (553 aa) |
| | snn-1 | ATP-grasp domain-containing protein. (474 aa) |
| | rimb-1 | RIM Binding protein. (1276 aa) |
| | Y39F10A.3 | Methyltransf_21 domain-containing protein. (309 aa) |
| | Y39G8B.7 | Uncharacterized protein. (179 aa) |
| | Y40H7A.4 | Methyltransf_21 domain-containing protein. (291 aa) |
| | rsy-1 | Regulator of SYnapse formation. (589 aa) |
| | Y55F3AM.11 | Methyltranfer_dom domain-containing protein. (323 aa) |
| | arl-8 | Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa) |
| | Y67D8C.22 | Uncharacterized protein. (225 aa) |
| | cpx-1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. (143 aa) |
| | snt-3 | SyNapTotagmin. (284 aa) |
| | aex-6 | Rab27. (215 aa) |
| | nep-23 | NEPrilysin metallopeptidase family. (714 aa) |
| | ced-5 | CED-5. (1781 aa) |
| | lnp-1 | Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family. (346 aa) |
| | wsp-1 | WASP (Actin cytoskeleton modulator) homolog. (781 aa) |
| | apd-3 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa) |
| | rab-3 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa) |
| | nep-24 | NEPrilysin metallopeptidase family. (567 aa) |
| | unc-17 | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa) |
| | unc-16 | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa) |
| | nep-25 | Peptidase_M13 domain-containing protein. (515 aa) |
| | ptr-23 | SSD domain-containing protein. (983 aa) |
| | eat-4 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa) |
| | unc-13 | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa) |
| | unc-25 | Glutamic acid decarboxylase. (508 aa) |
| | syd-2 | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. (1139 aa) |
| | sam-4 | Uncharacterized protein. (240 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | spd-5 | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. (1198 aa) |
| | syx-2 | Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (299 aa) |
| | itsn-1 | ITSN (Intersectin) family. (1087 aa) |
