STRINGSTRING
unc-89 unc-89 tiam-1 tiam-1 cgef-1 cgef-1 tag-77 tag-77 exc-5 exc-5 vav-1 vav-1 rhgf-1 rhgf-1 uig-1 uig-1 unc-73 unc-73 ephx-1 ephx-1 pix-1 pix-1 osg-1 osg-1 tag-52 tag-52 rhgf-2 rhgf-2 ect-2 ect-2 sos-1 sos-1 Y105E8A.25 Y105E8A.25 Y37A1B.17 Y37A1B.17 Y95B8A.12 Y95B8A.12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
unc-89Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa)
tiam-1DH domain-containing protein. (889 aa)
cgef-1DH domain-containing protein. (1055 aa)
tag-77Uncharacterized protein. (1006 aa)
exc-5Uncharacterized protein. (861 aa)
vav-1Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa)
rhgf-1RHo Guanine nucleotide exchange Factor. (1340 aa)
uig-1PH domain-containing protein. (972 aa)
unc-73Guanine nucleotide exchange factor UNC-73A. (2488 aa)
ephx-1EPHeXin (Eph-interacting GEF) homolog. (1159 aa)
pix-1PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa)
osg-1Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa)
tag-52Putative protein tag-52. (665 aa)
rhgf-2DH domain-containing protein. (1149 aa)
ect-2ECT2 (Mammalian Rho GEF) homolog. (932 aa)
sos-1Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa)
Y105E8A.25DH domain-containing protein. (1619 aa)
Y37A1B.17Uncharacterized protein. (1523 aa)
Y95B8A.12Pleckstrin homology and RHoGef (RhoGEF) domain containing. (628 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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