STRINGSTRING
rad-23 rad-23 ned-8 ned-8 rps-30 rps-30 C28D4.10 C28D4.10 C46F11.6 C46F11.6 F14D2.11 F14D2.11 C16C8.11 C16C8.11 art-1 art-1 usp-14 usp-14 C04B4.6 C04B4.6 ubql-1 ubql-1 ubq-1 ubq-1 ubl-5 ubl-5 ubq-2 ubq-2 B0303.4 B0303.4 prp-21 prp-21 F52C6.3 F52C6.3 tbcb-1 tbcb-1 pdr-1 pdr-1 ubl-1 ubl-1 bag-1 bag-1 F56F3.4 F56F3.4 F54D10.7 F54D10.7 tag-353 tag-353 T28A11.22 T28A11.22 T04A8.8 T04A8.8 smo-1 smo-1 K10C2.12 K10C2.12 C16C8.14 C16C8.14 C16C8.16 C16C8.16 C16C8.20 C16C8.20 C16C8.4 C16C8.4 C16C8.5 C16C8.5 ZK688.5 ZK688.5 F52C6.2 F52C6.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad-23Uncharacterized protein. (323 aa)
ned-8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. (77 aa)
rps-3040S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (130 aa)
C28D4.10Ubiquitin-like domain-containing protein. (125 aa)
C46F11.6Ubiquitin-like protein. (121 aa)
F14D2.11Ubiquitin-like domain-containing protein. (195 aa)
C16C8.11Ubiquitin-like domain-containing protein. (214 aa)
art-1Probable very-long-chain enoyl-CoA reductase art-1; Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurso [...] (308 aa)
usp-14Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (489 aa)
C04B4.6Ubiquitin-like domain-containing protein. (155 aa)
ubql-1Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] (502 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
ubl-5Ubiquitin-like protein 5. (73 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
B0303.4Uncharacterized protein B0303.4. (616 aa)
prp-21Yeast PRP (Splicing factor) related. (655 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
tbcb-1Tubulin-specific chaperone B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. (229 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
bag-1BAG family molecular chaperone regulator 1; May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner. (210 aa)
F56F3.4Uncharacterized protein. (341 aa)
F54D10.7Ubiquitin-like domain-containing protein. (264 aa)
tag-353Ubiquitin-like domain-containing protein. (361 aa)
T28A11.22Ubiquitin-like domain-containing protein. (170 aa)
T04A8.8Rad60-SLD domain-containing protein. (328 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
K10C2.12Ubiquitin-like domain-containing protein. (88 aa)
C16C8.14Ubiquitin-like domain-containing protein. (233 aa)
C16C8.16Ubiquitin-like domain-containing protein. (267 aa)
C16C8.20Ubiquitin-like domain-containing protein. (145 aa)
C16C8.4Ubiquitin-like domain-containing protein. (226 aa)
C16C8.5Ubiquitin-like domain-containing protein. (180 aa)
ZK688.5Uncharacterized protein ZK688.5. (1620 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.