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| | unc-86 | Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] (357 aa) |
| | ceh-30 | Homeobox protein ceh-30; Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway. (237 aa) |
| | ceh-7 | Homeobox protein ceh-7. (84 aa) |
| | irx-1 | Putative iroquois-class homeodomain protein irx-1. (377 aa) |
| | ceh-36 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. (257 aa) |
| | ceh-37 | Homeobox protein ceh-37; Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons; Belongs to the paired homeobox family. (278 aa) |
| | pal-1 | Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (270 aa) |
| | mls-2 | Homeobox domain-containing protein. (341 aa) |
| | ceh-84 | Homeobox domain-containing protein. (147 aa) |
| | ttx-3 | LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior. (409 aa) |
| | ceh-88 | Homeobox domain-containing protein. (262 aa) |
| | ceh-75 | Homeobox domain-containing protein. (188 aa) |
| | ceh-17 | Homeobox domain-containing protein. (237 aa) |
| | mec-3 | Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (321 aa) |
| | vab-3 | Homeobox domain-containing protein. (455 aa) |
| | ceh-1 | Homeobox protein ceh-1. (171 aa) |
| | ceh-40 | Homeobox protein ceh-40; Belongs to the TALE/PBX homeobox family. (329 aa) |
| | ceh-49 | One cut domain family member. (313 aa) |
| | ceh-19 | Homeobox protein ceh-19. (199 aa) |
| | ceh-60 | Homeobox domain-containing protein. (360 aa) |
| | ceh-38 | Homeobox protein ceh-38; Probable DNA-binding regulatory protein involved in cell-fate specification. (646 aa) |
| | unc-4 | Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily. (252 aa) |
| | pax-3 | PAX (Paired box) transcription factor. (308 aa) |
| | zag-1 | Zinc finger E-box-binding homeobox protein zag-1; Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron- specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Required for axon guidance. Involved in the proper development of the pharynx. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. (596 aa) |
| | ceh-89 | Homeobox domain-containing protein. (175 aa) |
| | ceh-22 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. (379 aa) |
| | ceh-20 | Homeobox protein ceh-20; Transcription factor that binds to the 5'-TGATNNAT(G/T)(G/A)- 3' PBC/Hox lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Has a role in the mig-13 pathway to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis and the anterior migration of BDU interneurons. Also required for normal vulval formation. (338 aa) |
| | tab-1 | Homeobox domain-containing protein. (197 aa) |
| | ceh-12 | Homeobox protein ceh-12. (180 aa) |
| | ceh-87 | Homeobox domain-containing protein. (186 aa) |
| | ceh-86 | Homeobox domain-containing protein. (733 aa) |
| | ceh-83 | Homeobox domain-containing protein. (543 aa) |
| | ceh-81 | Homeobox domain-containing protein. (466 aa) |
| | ceh-14 | Homeobox protein ceh-14; Confers thermosensory function to neurons. Required for correct AFD-mediated thermotaxis. (351 aa) |
| | ceh-27 | Homeobox domain-containing protein. (263 aa) |
| | hmbx-1 | Homeobox domain-containing protein. (424 aa) |
| | ceh-24 | Homeobox protein ceh-24; Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left- right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis. (299 aa) |
| | unc-39 | Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance. (335 aa) |
| | unc-42 | Homeobox domain-containing protein. (279 aa) |
| | ceh-6 | Homeobox protein ceh-6; Vital for embryonic development and essential for the proper function of the excretory cell. Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. (380 aa) |
| | ceh-28 | NK-2 family homeodomain protein CEH-28. (201 aa) |
| | lim-6 | LIM domain family. (316 aa) |
| | vab-7 | Homeobox protein vab-7; Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression. (247 aa) |
| | pha-2 | Homeobox domain-containing protein. (214 aa) |
| | cog-1 | Homeobox domain-containing protein. (256 aa) |
| | ceh-90 | Homeobox domain-containing protein. (193 aa) |
| | ceh-93 | Homeobox domain-containing protein. (508 aa) |
| | ceh-62 | Homeobox protein ceh-62. (278 aa) |
| | vab-15 | Homeobox protein vab-15; Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis. (225 aa) |
| | alr-1 | Homeobox domain-containing protein. (362 aa) |
| | ceh-13 | Homeobox protein ceh-13. (202 aa) |
| | ceh-54 | Homeobox domain-containing protein. (221 aa) |
| | ceh-99 | Homeobox domain-containing protein. (489 aa) |
| | ceh-41 | Homeobox domain-containing protein. (278 aa) |
| | ceh-21 | Homeobox protein ceh-21; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. (495 aa) |
| | ceh-39 | Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. (399 aa) |
| | ceh-43 | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. (282 aa) |
| | ceh-2 | Homeobox protein ceh-2; Required for activity of the M3 pharyngeal motor neuron. Belongs to the EMX homeobox family. (209 aa) |
| | nsy-7 | Neuronal SYmmetry. (294 aa) |
| | dsc-1 | Homeobox protein dsc-1; Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle. (310 aa) |
| | ceh-48 | One cut domain family member. (459 aa) |
| | ceh-5 | Homeobox protein ceh-5. (134 aa) |
| | ceh-16 | Homeobox protein engrailed-like ceh-16; Required in the seam cells during embryonic development. Represses the fusion of the seam cells with the neighboring dorsal and ventral epidermal cells by repressing the expression of the fusion effector eff-1. Required for early seam cell differentiation. Triggers the expression of elt-5 and other seam cell markers and is indispensable for alae formation (a hallmark of seam cell differentiation). Required for the maintenance of correct boundaries between the lateral rows of seam cells and the ventral and dorsal row of epidermal cells during embr [...] (187 aa) |
| | ceh-33 | Homeobox protein ceh-33. (261 aa) |
| | ceh-34 | Homeobox protein ceh-34; Acts as a transcription regulator. Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Together with eya- 1, required to specify the coelomocyte fate in embryonic and postembryonic precursors. Belongs to the SIX/Sine oculis homeobox family. (256 aa) |
| | ceh-53 | Homeobox domain-containing protein. (203 aa) |
| | mab-5 | Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family. (200 aa) |
| | egl-5 | Homeobox protein egl-5; Essential for the determination of specific neurons. (223 aa) |
| | lin-39 | Homeobox protein lin-39; Transcription factor that binds to the consensus 5'- TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Belongs [...] (253 aa) |
| | ceh-58 | Homeobox domain-containing protein. (327 aa) |
| | ceh-57 | Homeobox domain-containing protein. (343 aa) |
| | lim-7 | LIM domain family. (452 aa) |
| | ceh-63 | Homeobox domain-containing protein. (152 aa) |
| | unc-30 | Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] (323 aa) |
| | unc-62 | Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Belongs to the TALE/MEIS homeobox family. (564 aa) |
| | ceh-10 | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. (344 aa) |
| | ceh-32 | Homeobox protein ceh-32; Plays a role in head morphogenesis, expression is regulated by vab-3. (439 aa) |
| | ttx-1 | Homeobox domain-containing protein. (391 aa) |
| | ceh-100 | C. Elegans Homeobox. (1345 aa) |
| | eyg-1 | EYG (Drosophila eyegone) homolog. (314 aa) |
| | ceh-44 | Homeobox protein cut-like ceh-44; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. (1273 aa) |
| | ceh-9 | Homeobox protein ceh-9. (147 aa) |
| | ceh-91 | C. Elegans Homeobox. (685 aa) |
| | php-3 | Homeobox domain-containing protein. (275 aa) |
| | nob-1 | Homeobox domain-containing protein. (243 aa) |
| | ceh-51 | Homeobox domain-containing protein. (234 aa) |
| | ceh-76 | Homeobox domain-containing protein. (218 aa) |
| | zfh-2 | Zinc Finger and Homeobox. (1615 aa) |
| | duxl-1 | DUX (Vertebrate dual homeobox) Like. (430 aa) |
| | lin-11 | Protein lin-11; Probable transcription factor which is required for asymmetric division of vulval blast cells. Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons. Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons. Plays a role in the differentiation of the ADL sensory neurons. (405 aa) |
| | ceh-74 | Homeobox domain-containing protein. (252 aa) |
| | ceh-18 | Homeobox protein ceh-18; Directs gonadal sheath cell differentiation and function. Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development. Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis. Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization. May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in [...] (542 aa) |
| | lim-4 | Putative transcription factor LIM-4. (355 aa) |
| | dve-1 | Homeobox domain-containing protein. (468 aa) |
| | ceh-8 | Homeobox protein ceh-8. (276 aa) |
| | ceh-23 | Homeobox protein ceh-23. (305 aa) |
| | ceh-45 | Homeobox domain-containing protein. (229 aa) |
| | ceh-31 | Homeobox protein ceh-31. (260 aa) |
