STRINGSTRING
C01G10.1 C01G10.1 fcp-1 fcp-1 F36D3.5 F36D3.5 F33H12.1 F33H12.1 F26D2.10 F26D2.10 brc-1 brc-1 C18H2.5 C18H2.5 C18H2.1 C18H2.1 lig-4 lig-4 rev-1 rev-1 W04A8.1 W04A8.1 ect-2 ect-2 pis-1 pis-1 hsr-9 hsr-9 lpd-7 lpd-7 brd-1 brd-1 K02F6.4 K02F6.4 F56D5.9 F56D5.9 F42A6.5 F42A6.5 mus-101 mus-101 F37A4.4 F37A4.4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C01G10.1Uncharacterized protein. (1213 aa)
fcp-1RNA polymerase II subunit A C-terminal domain phosphatase; During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1. Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage. May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells. (659 aa)
F36D3.5Uncharacterized protein. (1215 aa)
F33H12.1BRCT domain-containing protein. (295 aa)
F26D2.10Uncharacterized protein. (1213 aa)
brc-1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] (612 aa)
C18H2.5Uncharacterized protein. (1195 aa)
C18H2.1ANK_REP_REGION domain-containing protein. (1770 aa)
lig-4LIGase. (741 aa)
rev-1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1027 aa)
W04A8.1Uncharacterized protein. (667 aa)
ect-2ECT2 (Mammalian Rho GEF) homolog. (932 aa)
pis-1PIS (Pax-2, IA-1/6, Smad-2 interacting protein) homolog. (1076 aa)
hsr-9Protein hsr-9; May have a role in DNA double-strand break repair following gamma-irradiation. (1165 aa)
lpd-7Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (531 aa)
brd-1BRCA1-associated RING domain protein 1; Involved in ubiquitination. Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. Involved in DNA repair. Has a reactive role in the response to DNA damage by ionizing radiation. Protects against chromosome non-disjunction and fragmentation to aid chromosome stability. (702 aa)
K02F6.4ANK_REP_REGION domain-containing protein. (1193 aa)
F56D5.9Uncharacterized protein. (1132 aa)
F42A6.5BRCT domain-containing protein. (102 aa)
mus-101Uncharacterized protein. (1182 aa)
F37A4.4Ankyrin repeat-containing protein F37A4.4. (1163 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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