STRINGSTRING
Y42G9A.3 Y42G9A.3 soc-2 soc-2 B0393.3 B0393.3 fli-1 fli-1 lron-3 lron-3 fbxl-1 fbxl-1 C06A8.6 C06A8.6 tol-1 tol-1 lrch-1 lrch-1 nxf-2 nxf-2 ran-2 ran-2 rsu-1 rsu-1 lron-4 lron-4 lron-1 lron-1 let-4 let-4 sym-1 sym-1 C48D1.1 C48D1.1 fshr-1 fshr-1 lron-15 lron-15 F09G8.5 F09G8.5 lron-5 lron-5 F13E9.1 F13E9.1 iglr-1 iglr-1 let-413 let-413 F28C1.3 F28C1.3 lron-6 lron-6 slt-1 slt-1 phlp-2 phlp-2 F44E5.2 F44E5.2 skpt-1 skpt-1 F56A8.3 F56A8.3 H04D03.4 H04D03.4 mog-2 mog-2 H24K24.2 H24K24.2 lron-7 lron-7 K05C4.9 K05C4.9 egg-6 egg-6 crml-1 crml-1 K08E7.8 K08E7.8 pxn-2 pxn-2 K10D2.8 K10D2.8 M57.2 M57.2 pan-1 pan-1 R02F11.4 R02F11.4 dma-1 dma-1 lron-14 lron-14 T05H4.3 T05H4.3 sds-22 sds-22 sma-10 sma-10 lron-8 lron-8 lron-9 lron-9 lrk-1 lrk-1 iglr-3 iglr-3 Y54E10A.6 Y54E10A.6 Y55F3C.9 Y55F3C.9 lron-11 lron-11 iglr-2 iglr-2 ZK546.2 ZK546.2 lron-2 lron-2 pxn-1 pxn-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y42G9A.3Uncharacterized protein. (375 aa)
soc-2Leucine-rich repeat protein soc-2; Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. (631 aa)
B0393.3Uncharacterized protein. (621 aa)
fli-1Protein flightless-1 homolog; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. (1257 aa)
lron-3LRRCT domain-containing protein. (369 aa)
fbxl-1F-box/LRR-repeat protein fbxl-1; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state. In hermaphrodites, may play a role in modulating the rate of defecation. (466 aa)
C06A8.6LRRcap domain-containing protein. (349 aa)
tol-1TIR domain-containing protein. (1221 aa)
lrch-1Calponin-homology (CH) domain-containing protein. (638 aa)
nxf-2Nuclear RNA export factor 2; May be involved in the export of cellular mRNA to the cytoplasm; Belongs to the NXF family. (405 aa)
ran-2Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate. (960 aa)
rsu-1Ras SUppressor homolog. (268 aa)
lron-4ELRR (Extracellular Leucine-Rich Repeat) ONly. (633 aa)
lron-1LRRCT domain-containing protein. (607 aa)
let-4Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. (773 aa)
sym-1SYM-1 protein. (680 aa)
C48D1.1Uncharacterized protein. (632 aa)
fshr-1G_PROTEIN_RECEP_F1_2 domain-containing protein. (932 aa)
lron-15ELRR (Extracellular Leucine-Rich Repeat) ONly. (1275 aa)
F09G8.5Uncharacterized protein F09G8.5. (461 aa)
lron-5LRRCT domain-containing protein. (656 aa)
F13E9.1PX domain-containing protein. (497 aa)
iglr-1Ig-like domain-containing protein. (695 aa)
let-413Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] (699 aa)
F28C1.3Protein phosphatase 1 regulatory subunit 37 homolog. (944 aa)
lron-6ELRR (Extracellular Leucine-Rich Repeat) ONly. (594 aa)
slt-1Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. (1410 aa)
phlp-2Protein phosphatase PHLPP-like protein; Probable protein phosphatase. (1126 aa)
F44E5.2Uncharacterized protein. (489 aa)
skpt-1F-box domain-containing protein. (421 aa)
F56A8.3Uncharacterized protein. (444 aa)
H04D03.4Uncharacterized protein. (688 aa)
mog-2Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa)
H24K24.2Uncharacterized protein. (473 aa)
lron-7LRRCT domain-containing protein. (586 aa)
K05C4.9Uncharacterized protein. (724 aa)
egg-6Leucine-rich repeat-containing protein egg-6; Required for apical extracellular matrix organization and epithelial junction maintenance. (961 aa)
crml-1Carm_PH domain-containing protein. (1056 aa)
K08E7.8Uncharacterized protein. (176 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
K10D2.8Uncharacterized protein. (335 aa)
M57.2Uncharacterized protein. (580 aa)
pan-1P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation. (594 aa)
R02F11.4Uncharacterized protein. (630 aa)
dma-1LRRCT domain-containing protein. (603 aa)
lron-14ELRR (Extracellular Leucine-Rich Repeat) ONly. (747 aa)
T05H4.3Uncharacterized protein. (1150 aa)
sds-22Protein phosphatase 1 regulatory subunit SDS22 homolog; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family. (326 aa)
sma-10Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. (881 aa)
lron-8LRRCT domain-containing protein. (341 aa)
lron-9ELRR (Extracellular Leucine-Rich Repeat) ONly. (653 aa)
lrk-1Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2393 aa)
iglr-3Ig-like domain-containing protein. (488 aa)
Y54E10A.6B3_4 domain-containing protein. (507 aa)
Y55F3C.9Uncharacterized protein. (732 aa)
lron-11ELRR (Extracellular Leucine-Rich Repeat) ONly. (542 aa)
iglr-2Immunoglobulin domain and leucine-rich repeat-containing protein 2. (773 aa)
ZK546.2Uncharacterized protein. (485 aa)
lron-2ELRR (Extracellular Leucine-Rich Repeat) ONly. (575 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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