STRINGSTRING
nurf-1 nurf-1 nra-3 nra-3 rpy-1 rpy-1 dpff-1 dpff-1 mys-4 mys-4 athp-1 athp-1 F01D4.5 F01D4.5 set-8 set-8 phf-31 phf-31 set-9 set-9 phf-32 phf-32 phf-34 phf-34 let-418 let-418 zfp-1 zfp-1 slx-1 slx-1 athp-2 athp-2 phf-33 phf-33 lsy-13 lsy-13 set-16 set-16 lin-59 lin-59 chd-3 chd-3 phf-30 phf-30 athp-3 athp-3 Y43H11AL.1 Y43H11AL.1 jmjd-2 jmjd-2 ing-3 ing-3 set-26 set-26 phf-15 phf-15 phf-14 phf-14 rbr-2 rbr-2 baz-2 baz-2 taf-3 taf-3 jmjd-1.2 jmjd-1.2 phf-10 phf-10 lin-49 lin-49 jmjd-1.1 jmjd-1.1 dgk-1 dgk-1 F53H1.4 F53H1.4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nurf-1Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa)
nra-3PHD-type domain-containing protein. (925 aa)
rpy-143 kDa receptor-associated protein of the synapse homolog; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. (615 aa)
dpff-1Zinc finger protein dpff-1; Belongs to the requiem/DPF family. (372 aa)
mys-4Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (617 aa)
athp-1AT Hook plus PHD finger transcription factor. (1150 aa)
F01D4.5PHD-type domain-containing protein. (223 aa)
set-8SET domain-containing protein. (512 aa)
phf-31PHD domain-containing protein. (168 aa)
set-9Histone-lysine N-methyltransferase set-9; Histone methyltransferase (By similarity). Might play a role in transcriptional regulation. Together with set-26, negatively regulates lifespan in a germline-independent, partially daf- 16-dependent fashion. Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline ; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1623 aa)
phf-32PHD domain-containing protein. (208 aa)
phf-34PHD-type domain-containing protein. (246 aa)
let-418Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa)
zfp-1Zinc finger protein zfp-1; Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys- 4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated [...] (867 aa)
slx-1Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] (443 aa)
athp-2AT Hook plus PHD finger transcription factor. (1427 aa)
phf-33PHD-type domain-containing protein. (650 aa)
lsy-13PHD domain-containing protein. (247 aa)
set-16Histone-lysine N-methyltransferase. (2475 aa)
lin-59Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa)
chd-3Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa)
phf-30PHD-type domain-containing protein. (234 aa)
athp-3PHD domain-containing protein. (286 aa)
Y43H11AL.1PHD-type domain-containing protein. (490 aa)
jmjd-2Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. (922 aa)
ing-3Inhibitor of growth protein. (490 aa)
set-26Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...] (1645 aa)
phf-15PHd Finger family. (741 aa)
phf-14PHd Finger family. (599 aa)
rbr-2Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation. (1477 aa)
baz-2Bromodomain Adjacent to Zinc finger domain, 2A/2B, homolog. (1390 aa)
taf-3PHD-type domain-containing protein. (1007 aa)
jmjd-1.2Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (929 aa)
phf-10PHD-type domain-containing protein. (447 aa)
lin-49Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1042 aa)
jmjd-1.1JmjC domain-containing protein. (548 aa)
dgk-1Diacylglycerol kinase. (952 aa)
F53H1.4PHD-type domain-containing protein. (1275 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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