(39 nodes) Leucine-rich repeat, typical subtype network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lron-5	LRRCT domain-containing protein. (656 aa)
	lron-15	ELRR (Extracellular Leucine-Rich Repeat) ONly. (1275 aa)
	sym-1	SYM-1 protein. (680 aa)
	let-4	Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. (773 aa)
	lron-1	LRRCT domain-containing protein. (607 aa)
	lron-4	ELRR (Extracellular Leucine-Rich Repeat) ONly. (633 aa)
	rsu-1	Ras SUppressor homolog. (268 aa)
	lrch-1	Calponin-homology (CH) domain-containing protein. (638 aa)
	tol-1	TIR domain-containing protein. (1221 aa)
	C06A8.6	LRRcap domain-containing protein. (349 aa)
	fli-1	Protein flightless-1 homolog; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. (1257 aa)
	soc-2	Leucine-rich repeat protein soc-2; Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. (631 aa)
	lron-9	ELRR (Extracellular Leucine-Rich Repeat) ONly. (653 aa)
	pxn-1	Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
	lron-2	ELRR (Extracellular Leucine-Rich Repeat) ONly. (575 aa)
	lrk-1	Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2393 aa)
	iglr-1	Ig-like domain-containing protein. (695 aa)
	let-413	Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] (699 aa)
	lron-6	ELRR (Extracellular Leucine-Rich Repeat) ONly. (594 aa)
	slt-1	Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. (1410 aa)
	phlp-2	Protein phosphatase PHLPP-like protein; Probable protein phosphatase. (1126 aa)
	F56A8.3	Uncharacterized protein. (444 aa)
	lron-7	LRRCT domain-containing protein. (586 aa)
	egg-6	Leucine-rich repeat-containing protein egg-6; Required for apical extracellular matrix organization and epithelial junction maintenance. (961 aa)
	pxn-2	PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
	K10D2.8	Uncharacterized protein. (335 aa)
	pan-1	P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation. (594 aa)
	dma-1	LRRCT domain-containing protein. (603 aa)
	lron-14	ELRR (Extracellular Leucine-Rich Repeat) ONly. (747 aa)
	T05H4.3	Uncharacterized protein. (1150 aa)
	sds-22	Protein phosphatase 1 regulatory subunit SDS22 homolog; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family. (326 aa)
	sma-10	Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. (881 aa)
	lron-8	LRRCT domain-containing protein. (341 aa)
	ZK546.2	Uncharacterized protein. (485 aa)
	lron-11	ELRR (Extracellular Leucine-Rich Repeat) ONly. (542 aa)
	Y54E10A.6	B3_4 domain-containing protein. (507 aa)
	Y42G9A.3	Uncharacterized protein. (375 aa)
	iglr-3	Ig-like domain-containing protein. (488 aa)
	F13E9.1	PX domain-containing protein. (497 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C06A8.6	pan-1	C06A8.6.1	M88.6b.1	LRRcap domain-containing protein.	P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation.	0.471
C06A8.6	rsu-1	C06A8.6.1	C34C12.5.1	LRRcap domain-containing protein.	Ras SUppressor homolog.	0.902
F56A8.3	Y54E10A.6	F56A8.3a.2	Y54E10A.6.1	Uncharacterized protein.	B3_4 domain-containing protein.	0.467
F56A8.3	let-4	F56A8.3a.2	C44H4.2.1	Uncharacterized protein.	Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance.	0.439
F56A8.3	lron-1	F56A8.3a.2	C44H4.1.1	Uncharacterized protein.	LRRCT domain-containing protein.	0.436
F56A8.3	lron-11	F56A8.3a.2	Y71F9B.8a.1	Uncharacterized protein.	ELRR (Extracellular Leucine-Rich Repeat) ONly.	0.528
F56A8.3	lron-9	F56A8.3a.2	T23G11.6a.2	Uncharacterized protein.	ELRR (Extracellular Leucine-Rich Repeat) ONly.	0.497
K10D2.8	dma-1	K10D2.8.1	T01G9.3.1	Uncharacterized protein.	LRRCT domain-containing protein.	0.403
K10D2.8	let-4	K10D2.8.1	C44H4.2.1	Uncharacterized protein.	Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance.	0.459
K10D2.8	let-413	K10D2.8.1	F26D11.11b.1	Uncharacterized protein.	Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...]	0.425
K10D2.8	lron-9	K10D2.8.1	T23G11.6a.2	Uncharacterized protein.	ELRR (Extracellular Leucine-Rich Repeat) ONly.	0.461
K10D2.8	sym-1	K10D2.8.1	C44H4.3.1	Uncharacterized protein.	SYM-1 protein.	0.437
Y42G9A.3	sym-1	Y42G9A.3a.3	C44H4.3.1	Uncharacterized protein.	SYM-1 protein.	0.415
Y54E10A.6	F56A8.3	Y54E10A.6.1	F56A8.3a.2	B3_4 domain-containing protein.	Uncharacterized protein.	0.467
Y54E10A.6	lron-1	Y54E10A.6.1	C44H4.1.1	B3_4 domain-containing protein.	LRRCT domain-containing protein.	0.406
ZK546.2	dma-1	ZK546.2a.1	T01G9.3.1	Uncharacterized protein.	LRRCT domain-containing protein.	0.416
ZK546.2	lron-1	ZK546.2a.1	C44H4.1.1	Uncharacterized protein.	LRRCT domain-containing protein.	0.490
ZK546.2	lron-9	ZK546.2a.1	T23G11.6a.2	Uncharacterized protein.	ELRR (Extracellular Leucine-Rich Repeat) ONly.	0.514
ZK546.2	sym-1	ZK546.2a.1	C44H4.3.1	Uncharacterized protein.	SYM-1 protein.	0.411
dma-1	K10D2.8	T01G9.3.1	K10D2.8.1	LRRCT domain-containing protein.	Uncharacterized protein.	0.403