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lgc-35 lgc-35 avr-14 avr-14 lgc-20 lgc-20 cup-4 cup-4 lgc-9 lgc-9 ggr-1 ggr-1 lgc-23 lgc-23 lgc-24 lgc-24 glc-4 glc-4 acr-19 acr-19 lgc-21 lgc-21 lev-8 lev-8 lgc-41 lgc-41 acr-9 acr-9 lgc-43 lgc-43 ggr-2 ggr-2 lgc-48 lgc-48 acc-2 acc-2 lgc-28 lgc-28 acr-11 acr-11 lgc-36 lgc-36 ggr-3 ggr-3 lev-1 lev-1 lgc-39 lgc-39 glc-1 glc-1 pbo-6 pbo-6 lgc-38 lgc-38 lgc-51 lgc-51 lgc-22 lgc-22 lgc-5 lgc-5 lgc-6 lgc-6 lgc-4 lgc-4 lgc-31 lgc-31 unc-38 unc-38 glc-2 glc-2 acr-16 acr-16 acr-15 acr-15 acr-21 acr-21 acr-18 acr-18 lgc-44 lgc-44 lgc-47 lgc-47 lgc-11 lgc-11 acr-17 acr-17 acc-3 acc-3 acc-1 acc-1 lgc-30 lgc-30 acr-23 acr-23 exp-1 exp-1 deg-3 deg-3 acr-5 acr-5 mod-1 mod-1 lgc-49 lgc-49 acr-2 acr-2 acr-3 acr-3 acr-12 acr-12 acr-10 acr-10 lgc-25 lgc-25 acr-20 acr-20 avr-15 avr-15 lgc-12 lgc-12 lgc-13 lgc-13 lgc-14 lgc-14 lgc-15 lgc-15 lgc-16 lgc-16 lgc-17 lgc-17 lgc-18 lgc-18 lgc-1 lgc-1 acr-14 acr-14 unc-29 unc-29 acr-7 acr-7 lgc-54 lgc-54 lgc-32 lgc-32 lgc-50 lgc-50 unc-49 unc-49 lgc-53 lgc-53 lgc-40 lgc-40 des-2 des-2 lgc-34 lgc-34 acc-4 acc-4 lgc-45 lgc-45 lgc-19 lgc-19 unc-63 unc-63 lgc-55 lgc-55 lgc-42 lgc-42 pbo-5 pbo-5 lgc-29 lgc-29 eat-2 eat-2 lgc-33 lgc-33 lgc-7 lgc-7 lgc-8 lgc-8 lgc-26 lgc-26 lgc-46 lgc-46 lgc-10 lgc-10 acr-25 acr-25 lgc-52 lgc-52 acr-24 acr-24 lgc-27 lgc-27 glc-3 glc-3 gab-1 gab-1 lgc-37 lgc-37 acr-8 acr-8 acr-6 acr-6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lgc-35Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
avr-14Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
lgc-20Neur_chan_LBD domain-containing protein. (454 aa)
cup-4Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (433 aa)
lgc-9Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
ggr-1Glycine receptor subunit beta-type 4; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Contributes to the generation of inhibitory postsynaptic currents. (473 aa)
lgc-23Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (403 aa)
lgc-24Neur_chan_LBD domain-containing protein. (389 aa)
glc-4Glutamate-gated ChLoride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (500 aa)
acr-19AcetylCholine Receptor. (560 aa)
lgc-21Neur_chan_LBD domain-containing protein. (462 aa)
lev-8Uncharacterized protein. (531 aa)
lgc-41Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (564 aa)
acr-9AcetylCholine Receptor. (534 aa)
lgc-43Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (679 aa)
ggr-2GABA/Glycine Receptor family (See gbr); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (546 aa)
lgc-48Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (366 aa)
acc-2Acetylcholine-gated chloride channel subunit acc-2; Acetylcholine-gated chloride channel subunit. Currents in channels are triggered in response to acetylcholine. Channel properties may be modulated by the formation of homomeric and heteromeric channels. (445 aa)
lgc-28Neur_chan_LBD domain-containing protein. (397 aa)
acr-11AcetylCholine Receptor. (461 aa)
lgc-36Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (536 aa)
ggr-3GABA/Glycine Receptor family (See gbr); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (445 aa)
lev-1Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa)
lgc-39Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (563 aa)
glc-1Glutamate-gated chloride channel alpha; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. P [...] (461 aa)
pbo-6Proton-gated ion channel subunit pbo-6; Forms a proton-gated ion channel with pbo-5 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Not necessary for stimulation of posterior body contraction (pBoc). Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline. (422 aa)
lgc-38Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa)
lgc-51Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
lgc-22ShKT domain-containing protein. (445 aa)
lgc-5Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (433 aa)
lgc-6Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (425 aa)
lgc-4Ligand-gated ion channel 4; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (635 aa)
lgc-31Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (675 aa)
unc-38Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa)
glc-2Glutamate-gated chloride channel subunit beta; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. (434 aa)
acr-16Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. (498 aa)
acr-15AcetylCholine Receptor. (479 aa)
acr-21AcetylCholine Receptor. (635 aa)
acr-18AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (510 aa)
lgc-44Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (618 aa)
lgc-47Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (428 aa)
lgc-11Acetylcholine receptor (51.1 kD) (Acr-22); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (434 aa)
acr-17AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
acc-3Acetylcholine-gated chloride channel subunit acc-3; Probable acetylcholine-gated chloride channel regulatory subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. Belongs to the ligand-gated ion channel (TC 1.A.9) family. (517 aa)
acc-1Acetylcholine-gated chloride channel subunit acc-1; Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine. (470 aa)
lgc-30Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (529 aa)
acr-23Betaine receptor acr-23; Betaine receptor that functions as a ligand-gated non- selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA. (545 aa)
exp-1Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. (539 aa)
deg-3Acetylcholine receptor subunit alpha-type deg-3; Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (564 aa)
acr-5Acetylcholine receptor subunit alpha-type acr-5; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (598 aa)
mod-1Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
lgc-49Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
acr-2Acetylcholine receptor subunit beta-type acr-2; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (575 aa)
acr-3Acetylcholine receptor subunit beta-type acr-3; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. (487 aa)
acr-12Nicotinic acetylcholine receptor-like subunit ACR-12. (573 aa)
acr-10AcetylCholine Receptor. (557 aa)
lgc-25Neur_chan_LBD domain-containing protein. (502 aa)
acr-20AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (556 aa)
avr-15Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (657 aa)
lgc-12Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (428 aa)
lgc-13Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (399 aa)
lgc-14Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (400 aa)
lgc-15Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (399 aa)
lgc-16Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (401 aa)
lgc-17Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (401 aa)
lgc-18Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (399 aa)
lgc-1Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (371 aa)
acr-14AcetylCholine Receptor. (500 aa)
unc-29Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa)
acr-7Acetylcholine receptor subunit alpha-type acr-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (538 aa)
lgc-54Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (493 aa)
lgc-32Neur_chan_LBD domain-containing protein. (390 aa)
lgc-50Ligand-gated ion channel 50. (491 aa)
unc-49Ionotropic GABA receptor subunit UNC-49B.3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa)
lgc-53Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
lgc-40Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (494 aa)
des-2Acetylcholine receptor subunit alpha-type des-2; Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (559 aa)
lgc-34Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (390 aa)
acc-4Acetylcholine-gated ion channel acc-4; Probable acetylcholine-gated chloride channel subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. May function with lgc-46 to regulate synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. (408 aa)
lgc-45Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (1046 aa)
lgc-19Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (400 aa)
unc-63Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa)
lgc-55Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (538 aa)
lgc-42Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (412 aa)
pbo-5Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (509 aa)
lgc-29Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (398 aa)
eat-2Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa)
lgc-33Neur_chan_LBD domain-containing protein. (401 aa)
lgc-7Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (439 aa)
lgc-8Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (438 aa)
lgc-26Neur_chan_LBD domain-containing protein. (486 aa)
lgc-46Probable ligand-gated ion channel 46; Probable component of a ligand-gated anion channel. Negatively regulates synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. Role in synaptic vesicle release kinetics may be in association with the ligand-gated ion channel protein acc-4. (508 aa)
lgc-10Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
acr-25AcetylCholine Receptor. (544 aa)
lgc-52Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (423 aa)
acr-24AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (578 aa)
lgc-27Neur_chan_LBD domain-containing protein. (428 aa)
glc-3Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa)
gab-1Gamma-aminobutyric acid receptor subunit beta; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. (550 aa)
lgc-37Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
acr-8Acetylcholine receptor 8. (537 aa)
acr-6AcetylCholine Receptor. (551 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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