STRINGSTRING
Y71F9AL.9 Y71F9AL.9 C06E1.9 C06E1.9 ubc-21 ubc-21 ubc-22 ubc-22 nxf-1 nxf-1 cox-16 cox-16 C36E6.2 C36E6.2 ubql-1 ubql-1 ubxn-1 ubxn-1 tli-1 tli-1 ubc-20 ubc-20 F43C1.5 F43C1.5 F49C12.9 F49C12.9 tsfm-1 tsfm-1 dcn-1 dcn-1 H40L08.1 H40L08.1 pqn-59 pqn-59 sqst-1 sqst-1 T24B8.7 T24B8.7 usp-5 usp-5 spe-48 spe-48 tdpt-1 tdpt-1 eel-1 eel-1 rad-23 rad-23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y71F9AL.9Uncharacterized protein. (314 aa)
C06E1.9Uncharacterized protein C06E1.9. (643 aa)
ubc-21Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins. (214 aa)
ubc-22UBiquitin Conjugating enzyme. (182 aa)
nxf-1Nuclear RNA export factor 1; Involved in RNA export from the nucleus to the cytoplasm; Belongs to the NXF family. (609 aa)
cox-16Probable peptidyl-tRNA hydrolase 2; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis; Belongs to the PTH2 family. (316 aa)
C36E6.2N_BRCA1_IG domain-containing protein. (239 aa)
ubql-1Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] (502 aa)
ubxn-1UBX domain-containing protein 1; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. (299 aa)
tli-1ToLlIp homolog. (243 aa)
ubc-20UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
F43C1.5Uncharacterized protein F43C1.5. (221 aa)
F49C12.9UBA domain-containing protein. (305 aa)
tsfm-1Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (316 aa)
dcn-1Defective in cullin neddylation protein 1; Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes. (295 aa)
H40L08.1Uncharacterized protein. (444 aa)
pqn-59Prion-like-(Q/N-rich)-domain-bearing protein. (712 aa)
sqst-1SeQueSTosome related. (693 aa)
T24B8.7Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (2938 aa)
usp-5Ubiquitin carboxyl-terminal hydrolase. (789 aa)
spe-48UBA domain-containing protein. (337 aa)
tdpt-15'-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals; Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily. (362 aa)
eel-1Enhancer of EfL-1 mutant phenotype. (4185 aa)
rad-23Uncharacterized protein. (323 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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