STRINGSTRING
his-45 his-45 his-47 his-47 his-48 his-48 his-46 his-46 taf-3 taf-3 taf-13 taf-13 his-35 his-35 his-41 his-41 his-69 his-69 his-70 his-70 his-54 his-54 his-44 his-44 F20D6.9 F20D6.9 nfyc-1 nfyc-1 drap-1 drap-1 taf-11.3 taf-11.3 his-71 his-71 his-39 his-39 taf-11.1 taf-11.1 dro-1 dro-1 cpar-1 cpar-1 his-57 his-57 hcp-3 hcp-3 taf-11.2 taf-11.2 htz-1 htz-1 taf-9 taf-9 T26A5.8 T26A5.8 sos-1 sos-1 his-74 his-74 taf-6.1 taf-6.1 his-73 his-73 nfyb-1 nfyb-1 Y48E1C.1 Y48E1C.1 Y53F4B.3 Y53F4B.3 Y54E2A.8 Y54E2A.8 taf-12 taf-12 ZC155.2 ZC155.2 htas-1 htas-1 taf-8 taf-8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-45Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
his-47Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
taf-3PHD-type domain-containing protein. (1007 aa)
taf-13TAF (TBP-associated transcription factor) family. (121 aa)
his-35Histone H2A; Belongs to the histone H2A family. (127 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-69Putative histone H3.3-like type 3; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (127 aa)
his-70Histone H3.3-like type 1; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (134 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
F20D6.9Histone domain-containing protein. (118 aa)
nfyc-1CBFD_NFYB_HMF domain-containing protein. (232 aa)
drap-1CBFD_NFYB_HMF domain-containing protein. (331 aa)
taf-11.3TAFII28 domain-containing protein. (228 aa)
his-71Histone H3.3 type 1; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central [...] (136 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
taf-11.1TAFII28 domain-containing protein. (345 aa)
dro-1CBFD_NFYB_HMF domain-containing protein. (184 aa)
cpar-1Histone H3-like centromeric protein cpar-1; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis. (261 aa)
his-57Histone H2A; Belongs to the histone H2A family. (147 aa)
hcp-3Histone H3-like centromeric protein hcp-3; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis. Not required for chromosome segregation during meiosis. (288 aa)
taf-11.2TAFII28 domain-containing protein. (281 aa)
htz-1Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...] (140 aa)
taf-9TAF (TBP-associated transcription factor) family. (183 aa)
T26A5.8CBFD_NFYB_HMF domain-containing protein. (137 aa)
sos-1Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa)
his-74Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
taf-6.1TAF domain-containing protein. (470 aa)
his-73Histone domain-containing protein. (46 aa)
nfyb-1CBFD_NFYB_HMF domain-containing protein. (403 aa)
Y48E1C.1Uncharacterized protein. (447 aa)
Y53F4B.3CBFD_NFYB_HMF domain-containing protein. (179 aa)
Y54E2A.8Uncharacterized protein. (485 aa)
taf-12TFIID_20kDa domain-containing protein. (342 aa)
ZC155.2Histone domain-containing protein. (213 aa)
htas-1Histone H2A; Belongs to the histone H2A family. (145 aa)
taf-8BTP domain-containing protein. (497 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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