STRINGSTRING
tir-1 tir-1 ppfr-1 ppfr-1 tbcd-1 tbcd-1 puf-6 puf-6 H04D03.3 H04D03.3 fbf-1 fbf-1 evl-14 evl-14 vacl-14 vacl-14 apr-1 apr-1 hmp-2 hmp-2 K05C4.7 K05C4.7 uso-1 uso-1 M01E11.2 M01E11.2 mop-25.1 mop-25.1 imb-2 imb-2 wapl-1 wapl-1 cls-2 cls-2 apb-3 apb-3 T05H4.10 T05H4.10 T06D8.2 T06D8.2 sftb-1 sftb-1 T08D2.8 T08D2.8 vha-15 vha-15 T14G10.5 T14G10.5 ekl-6 ekl-6 T16G12.6 T16G12.6 ima-1 ima-1 apa-2 apa-2 rpn-1 rpn-1 sys-1 sys-1 zer-1 zer-1 mop-25.3 mop-25.3 T28B8.3 T28B8.3 T28B8.4 T28B8.4 T28F4.4 T28F4.4 W04A4.5 W04A4.5 puf-9 puf-9 W07G4.3 W07G4.3 pptr-1 pptr-1 apd-3 apd-3 mat-2 mat-2 cand-1 cand-1 jac-1 jac-1 apg-1 apg-1 ced-12 ced-12 hcp-6 hcp-6 copb-1 copb-1 Y38E10A.22 Y38E10A.22 dpy-28 dpy-28 pqn-85 pqn-85 puf-3 puf-3 Y46E12BL.2 Y46E12BL.2 Y48A6C.4 Y48A6C.4 xpo-2 xpo-2 gcn-1 gcn-1 frl-1 frl-1 mop-25.2 mop-25.2 Y53C12A.7 Y53C12A.7 Y54E10A.11 Y54E10A.11 Y54H5A.2 Y54H5A.2 Y67A10A.7 Y67A10A.7 Y69A2AR.16 Y69A2AR.16 agef-1 agef-1 apb-1 apb-1 puf-11 puf-11 ZC581.9 ZC581.9 cls-3 cls-3 dcaf-1 dcaf-1 toe-1 toe-1 xpo-1 xpo-1 ZK792.5 ZK792.5 che-12 che-12 let-363 let-363 puf-7 puf-7 wrm-1 wrm-1 ufd-3 ufd-3 cls-1 cls-1 zyg-11 zyg-11 daf-15 daf-15 soap-1 soap-1 pptr-2 pptr-2 dohh-1 dohh-1 C14C10.5 C14C10.5 rpn-2 rpn-2 ntl-9 ntl-9 C27C12.1 C27C12.1 puf-8 puf-8 gadr-2 gadr-2 hecd-1 hecd-1 hpo-27 hpo-27 C35A5.8 C35A5.8 fhod-1 fhod-1 C48D1.1 C48D1.1 xpo-3 xpo-3 imb-3 imb-3 bar-1 bar-1 D1043.1 D1043.1 nekl-4 nekl-4 D2045.2 D2045.2 kap-1 kap-1 cyk-1 cyk-1 btf-1 btf-1 vps-15 vps-15 puf-12 puf-12 rme-8 rme-8 utp-20 utp-20 fbf-2 fbf-2 zyg-9 zyg-9 F23B12.7 F23B12.7 symk-1 symk-1 ima-2 ima-2 imb-1 imb-1 capg-1 capg-1 unc-45 unc-45 ima-3 ima-3 smk-1 smk-1 insc-1 insc-1 F46C5.6 F46C5.6 gadr-6 gadr-6 paa-1 paa-1 vha-18 vha-18 F53B2.5 F53B2.5 F53B3.3 F53B3.3 tsr-1 tsr-1 F54A3.2 F54A3.2 puf-5 puf-5 capg-2 capg-2 daam-1 daam-1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tir-1NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa)
ppfr-1Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex. (1562 aa)
tbcd-1Tubulin-specific chaperone D; Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization ; Belongs to the TBCD family. (1232 aa)
puf-6Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa)
H04D03.3Uncharacterized protein. (409 aa)
fbf-1Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa)
evl-14Uncharacterized protein. (1570 aa)
vacl-14VAC (Yeast VACuole morphology)-Like. (694 aa)
apr-1Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...] (1188 aa)
hmp-2Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. (704 aa)
K05C4.7Armadillo repeat-containing protein 1. (289 aa)
uso-1USO1 (Yeast transport protein) homolog. (941 aa)
M01E11.2DUF1716 domain-containing protein. (544 aa)
mop-25.1MO25 (MOuse embryo scaffolding Protein) homolog. (636 aa)
imb-2Importin N-terminal domain-containing protein. (889 aa)
wapl-1Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene [...] (748 aa)
cls-2Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development. (1023 aa)
apb-3AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (945 aa)
T05H4.10NopRA1 domain-containing protein. (476 aa)
T06D8.2UVR domain-containing protein. (689 aa)
sftb-1SF3b1 domain-containing protein. (1322 aa)
T08D2.8TOG domain-containing protein. (388 aa)
vha-15Probable V-type proton ATPase subunit H 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (470 aa)
T14G10.5Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (885 aa)
ekl-6Uncharacterized protein. (964 aa)
T16G12.6Xpo1 domain-containing protein. (930 aa)
ima-1Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. (524 aa)
apa-2AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa)
rpn-126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa)
sys-1SYmmetrical Sister cell hermaphrodite gonad defect. (811 aa)
zer-1Zyg eleven-related protein 1; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zer-1-cul-2-elc-1. (895 aa)
mop-25.3MO25-like protein 3; Belongs to the Mo25 family. (453 aa)
T28B8.3DUF3437 domain-containing protein. (1879 aa)
T28B8.4Uncharacterized protein. (1874 aa)
T28F4.4Uncharacterized protein. (929 aa)
W04A4.5INTegrator complex Subunit homolog. (1071 aa)
puf-9PUM-HD domain-containing protein. (703 aa)
W07G4.3SCY1 Like pseudokinase. (820 aa)
pptr-1Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...] (542 aa)
apd-3AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa)
mat-2Anaphase-promoting complex subunit 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors [...] (1505 aa)
cand-1Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable). (1274 aa)
jac-1Juxtamembrane domain-associated catenin; May act as a positive modulator of hmr-1 function during epidermal morphogenesis. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the beta-catenin family. (1256 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
ced-12Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth. (738 aa)
hcp-6Condensin-2 complex subunit. (1758 aa)
copb-1Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (971 aa)
Y38E10A.22Uncharacterized protein. (428 aa)
dpy-28Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] (1499 aa)
pqn-85Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). (2203 aa)
puf-3PUM-HD domain-containing protein. (502 aa)
Y46E12BL.2NUC173 domain-containing protein. (1334 aa)
Y48A6C.4Ipi1_N domain-containing protein. (365 aa)
xpo-2Importin N-terminal domain-containing protein. (938 aa)
gcn-1TOG domain-containing protein. (2651 aa)
frl-1FRL (Formin Related gene in Leukocytes) homolog. (1115 aa)
mop-25.2MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis. (338 aa)
Y53C12A.7Uncharacterized protein. (134 aa)
Y54E10A.11E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family. (1446 aa)
Y54H5A.2Uncharacterized protein. (375 aa)
Y67A10A.7Arm_2 domain-containing protein. (345 aa)
Y69A2AR.16Uncharacterized protein. (1120 aa)
agef-1SEC7 domain-containing protein. (1594 aa)
apb-1AP complex subunit beta. (955 aa)
puf-11PUM-HD domain-containing protein. (505 aa)
ZC581.9Protein kinase domain-containing protein. (834 aa)
cls-3Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (983 aa)
dcaf-1DDB1- and CUL4-associated factor homolog 1; Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex. (1701 aa)
toe-1HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (1650 aa)
xpo-1Importin N-terminal domain-containing protein. (1080 aa)
ZK792.5Uncharacterized protein. (645 aa)
che-12Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa)
let-363Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] (2695 aa)
puf-7Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa)
wrm-1Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (796 aa)
ufd-3Ubiquitin fusion degradation protein 3 homolog; Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2. (860 aa)
cls-1Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division. (1378 aa)
zyg-11Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment. (799 aa)
daf-15Raptor_N domain-containing protein. (1800 aa)
soap-1Sorting Of Apical Proteins. (2076 aa)
pptr-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (607 aa)
dohh-1Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. (298 aa)
C14C10.5Uncharacterized protein. (1908 aa)
rpn-226S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa)
ntl-9NOT-Like (Yeast CCR4/NOT complex component). (330 aa)
C27C12.1Uncharacterized protein. (264 aa)
puf-8PUM-HD domain-containing protein. (535 aa)
gadr-2Uncharacterized protein. (732 aa)
hecd-1E3 ubiquitin-protein ligase hecd-1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins. Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision. Negatively regulates glp-1 activity in germline proliferation. May play a role in the formation of fibrous organelles, a hemidesmosome-like s [...] (2650 aa)
hpo-27Uncharacterized protein. (1768 aa)
C35A5.8Uncharacterized protein. (1096 aa)
fhod-1Formin HOmology Domain. (1698 aa)
C48D1.1Uncharacterized protein. (632 aa)
xpo-3Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (952 aa)
imb-3Importin N-terminal domain-containing protein. (1092 aa)
bar-1Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (811 aa)
D1043.1INTegrator complex Subunit homolog. (910 aa)
nekl-4Serine/threonine-protein kinase D1044.8. (981 aa)
D2045.2Uncharacterized protein. (1810 aa)
kap-1Kinesin-Associated Protein. (696 aa)
cyk-1CYtoKinesis defect. (1437 aa)
btf-1BTAF (TBP-associated factor) homolog. (1649 aa)
vps-15Related to yeast Vacuolar Protein Sorting factor. (1354 aa)
puf-12Pumilio domain-containing protein 12. (766 aa)
rme-8J domain-containing protein. (2279 aa)
utp-20DRIM domain-containing protein. (2613 aa)
fbf-2Fem-3 mRNA-binding factor 2; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the d [...] (632 aa)
zyg-9Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. (1415 aa)
F23B12.7Uncharacterized protein F23B12.7; Belongs to the CBF/MAK21 family. (953 aa)
symk-1SYMpleKin cleavage and polyadenylation factor. (1143 aa)
ima-2Importin subunit alpha-2; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). (531 aa)
imb-1Importin N-terminal domain-containing protein. (896 aa)
capg-1Condensin complex subunit capg-1; Member of two distinct condensin I complexes, the condensin I complex and the condensin I-like dosage compensation complex. The condensin I complex is required for conversion of interphase chromatin into mitotic-like condensed chromosomes and for chromosome segregation in meiosis and mitosis. As a member of the condensin I complex, further controls crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Regulatory subunit of the condensin I-like dosage compens [...] (1153 aa)
unc-45TPR_REGION domain-containing protein. (961 aa)
ima-3Importin subunit alpha-3; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs. Necessary for correct nucleoporin localization within the germline. Belongs to the importin alpha family. (514 aa)
smk-1SMK-1 domain-containing protein. (1085 aa)
insc-1INSCuteable (Drososphila asymmetric cell division protein) homolog. (715 aa)
F46C5.6Uncharacterized protein. (945 aa)
gadr-6Uncharacterized protein. (710 aa)
paa-1Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...] (590 aa)
vha-18Probable V-type proton ATPase subunit H 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (451 aa)
F53B2.5Uncharacterized protein. (476 aa)
F53B3.3Uncharacterized protein. (689 aa)
tsr-1Xpo1 domain-containing protein. (829 aa)
F54A3.2Uncharacterized protein. (748 aa)
puf-5Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (553 aa)
capg-2CAP-G condensin subunit. (1010 aa)
daam-1FH2 domain-containing protein. (987 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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