STRINGSTRING
erp-44.1 erp-44.1 ZK973.11 ZK973.11 Y73B6BL.12 Y73B6BL.12 txdc-12.1 txdc-12.1 Y55F3AR.2 Y55F3AR.2 txl-1 txl-1 Y52E8A.3 Y52E8A.3 Y49E10.4 Y49E10.4 dnj-27 dnj-27 trx-4 trx-4 prdx-6 prdx-6 W01B11.6 W01B11.6 T28A11.13 T28A11.13 T20D4.7 T20D4.7 T10H10.2 T10H10.2 gpx-6 gpx-6 T05F1.11 T05F1.11 prdx-3 prdx-3 R05H5.3 R05H5.3 gpx-7 gpx-7 trx-3 trx-3 trx-5 trx-5 pdi-3 pdi-3 png-1 png-1 F47B7.2 F47B7.2 dpy-11 dpy-11 erp-44.3 erp-44.3 F35G2.1 F35G2.1 F29B9.5 F29B9.5 gpx-1 gpx-1 F17B5.1 F17B5.1 prdx-2 prdx-2 D2092.4 D2092.4 glrx-3 glrx-3 dnj-8 dnj-8 C53D6.4 C53D6.4 C35D10.10 C35D10.10 C35B1.5 C35B1.5 C32D5.8 C32D5.8 C30H6.8 C30H6.8 C14B9.2 C14B9.2 pdi-1 pdi-1 gpx-3 gpx-3 gpx-5 gpx-5 pdi-2 pdi-2 erp-44.2 erp-44.2 txdc-9 txdc-9 pdi-6 pdi-6 trx-1 trx-1 trx-2 trx-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
erp-44.1Thioredoxin domain-containing protein. (411 aa)
ZK973.11Thioredoxin domain-containing protein. (447 aa)
Y73B6BL.12Thioredoxin; Belongs to the thioredoxin family. (136 aa)
txdc-12.1Thioredoxin domain-containing protein. (186 aa)
Y55F3AR.2Thioredoxin domain-containing protein. (254 aa)
txl-1Thioredoxin-like protein TXL. (284 aa)
Y52E8A.3Thioredoxin domain-containing protein. (149 aa)
Y49E10.4Uncharacterized protein; Belongs to the protein disulfide isomerase family. (436 aa)
dnj-27DNaJ domain (Prokaryotic heat shock protein). (788 aa)
trx-4Thioredoxin; Belongs to the thioredoxin family. (107 aa)
prdx-6Thioredoxin domain-containing protein. (231 aa)
W01B11.6Thioredoxin domain-containing protein. (109 aa)
T28A11.13Thioredoxin domain-containing protein. (122 aa)
T20D4.7Thioredoxin domain-containing protein. (141 aa)
T10H10.2Sulfhydryl oxidase. (574 aa)
gpx-6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
T05F1.11Thioredoxin domain-containing protein. (676 aa)
prdx-3Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (226 aa)
R05H5.3Thioredoxin domain-containing protein. (149 aa)
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
trx-3Thioredoxin domain-containing protein. (158 aa)
trx-5Thioredoxin domain-containing protein. (142 aa)
pdi-3Protein disulfide-isomerase. (488 aa)
png-1Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta- aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native protein [...] (606 aa)
F47B7.2Sulfhydryl oxidase. (678 aa)
dpy-11Thioredoxin domain-containing protein. (246 aa)
erp-44.3Thioredoxin domain-containing protein. (434 aa)
F35G2.1Sulfhydryl oxidase. (601 aa)
F29B9.5Thioredoxin domain-containing protein. (151 aa)
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
F17B5.1Thioredoxin domain-containing protein. (777 aa)
prdx-2Thioredoxin domain-containing protein. (201 aa)
D2092.4Thioredoxin domain-containing protein. (363 aa)
glrx-3GLutaRedoXin. (345 aa)
dnj-8J domain-containing protein. (813 aa)
C53D6.4Thioredoxin domain-containing protein. (325 aa)
C35D10.10Thioredoxin-related transmembrane protein 2 homolog. (265 aa)
C35B1.5Thioredoxin domain-containing protein. (151 aa)
C32D5.8Thioredoxin domain-containing protein. (167 aa)
C30H6.8Thioredoxin domain-containing protein. (178 aa)
C14B9.2Probable protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (618 aa)
pdi-1Protein disulfide-isomerase 1; Belongs to the protein disulfide isomerase family. (485 aa)
gpx-3Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
gpx-5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
pdi-2Protein disulfide-isomerase 2; Involved in cuticle formation. May play a role in the unfolded protein response. Belongs to the protein disulfide isomerase family. (493 aa)
erp-44.2Endoplasmic reticulum resident protein 44.2. (413 aa)
txdc-9Thioredoxin domain-containing protein 9; Required for normal microtubule organization and function. Regulates tubulin acetylation in ALM and PLM neurons. (208 aa)
pdi-6Protein disulfide-isomerase A6 homolog; May function as a chaperone that inhibits aggregation of misfolded proteins (By similarity). May negatively regulate the unfolded protein response (UPR) through binding to UPR sensors ; Belongs to the protein disulfide isomerase family. (440 aa)
trx-1Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Shown to facilitate the reduction of insulin disulfide bonds. Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide. Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to [...] (115 aa)
trx-2Probable thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (145 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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