STRINGSTRING
F26H9.5 F26H9.5 nkat-1 nkat-1 tatn-1 tatn-1 sptl-2 sptl-2 gta-1 gta-1 mocs-1 mocs-1 nkat-3 nkat-3 R102.4 R102.4 gldc-1 gldc-1 eppl-1 eppl-1 secs-1 secs-1 got-1.2 got-1.2 T04F3.1 T04F3.1 T09B4.8 T09B4.8 got-2.1 got-2.1 hdl-1 hdl-1 cth-2 cth-2 F13H8.9 F13H8.9 Y71H2B.5 Y71H2B.5 spl-1 spl-1 unc-25 unc-25 spl-3 spl-3 T25B9.1 T25B9.1 sptl-3 sptl-3 agxt-1 agxt-1 got-2.2 got-2.2 kynu-1 kynu-1 C14H10.3 C14H10.3 B0205.6 B0205.6 spl-2 spl-2 mel-32 mel-32 basl-1 basl-1 C32F10.8 C32F10.8 sptl-1 sptl-1 oatr-1 oatr-1 bas-1 bas-1 hdl-2 hdl-2 cbl-1 cbl-1 tdc-1 tdc-1 cth-1 cth-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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F26H9.5Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (370 aa)
nkat-1Aminotran_1_2 domain-containing protein. (437 aa)
tatn-1Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (464 aa)
sptl-2Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (586 aa)
gta-1Probable 4-aminobutyrate aminotransferase, mitochondrial. (483 aa)
mocs-1Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (709 aa)
nkat-3Aminotran_1_2 domain-containing protein. (441 aa)
R102.4Uncharacterized protein R102.4; Belongs to the threonine aldolase family. (413 aa)
gldc-1Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (979 aa)
eppl-1Ethanolamine-phosphate phospho-lyase homolog 1. (467 aa)
secs-1O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Belongs to the SepSecS family. (523 aa)
got-1.2Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. (408 aa)
T04F3.1Aminotran_1_2 domain-containing protein. (3460 aa)
T09B4.8Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
got-2.1Aspartate aminotransferase. (419 aa)
hdl-1Probable aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (905 aa)
cth-2Putative cystathionine gamma-lyase 2; Belongs to the trans-sulfuration enzymes family. (392 aa)
F13H8.9Aminotran_5 domain-containing protein. (387 aa)
Y71H2B.5Uncharacterized protein. (957 aa)
spl-1Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Essential for normal development, intestinal integrity, growth and reproduction. (552 aa)
unc-25Glutamic acid decarboxylase. (508 aa)
spl-3Sphingosine Phosphate Lyase. (606 aa)
T25B9.1Aminotran_1_2 domain-containing protein. (403 aa)
sptl-3Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (521 aa)
agxt-1Serine--pyruvate aminotransferase. (405 aa)
got-2.2Aspartate aminotransferase. (414 aa)
kynu-1Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (478 aa)
C14H10.3Uncharacterized protein. (802 aa)
B0205.6Aminotran_5 domain-containing protein. (412 aa)
spl-2Sphingosine Phosphate Lyase. (542 aa)
mel-32Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa)
basl-1BAS-Like. (509 aa)
C32F10.8Aminotran_1_2 domain-containing protein. (504 aa)
sptl-1Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. (458 aa)
oatr-1Probable ornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
bas-1Biogenic Amine Synthesis related. (523 aa)
hdl-2Histidine Decarboxyase Like. (611 aa)
cbl-1Cystathionine Beta Lyase. (451 aa)
tdc-1Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family. (705 aa)
cth-1CystaTHionine gamma lyase. (392 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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