STRINGSTRING
ubc-21 ubc-21 ubc-22 ubc-22 cox-16 cox-16 ubql-1 ubql-1 F49C12.9 F49C12.9 par-1 par-1 sqst-1 sqst-1 T24B8.7 T24B8.7 usp-5 usp-5 spe-48 spe-48 eel-1 eel-1 rad-23 rad-23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ubc-21Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins. (214 aa)
ubc-22UBiquitin Conjugating enzyme. (182 aa)
cox-16Probable peptidyl-tRNA hydrolase 2; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis; Belongs to the PTH2 family. (316 aa)
ubql-1Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] (502 aa)
F49C12.9UBA domain-containing protein. (305 aa)
par-1Serine/threonine-protein kinase par-1; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. Involved in the establishment of neuronal polarity. (1216 aa)
sqst-1SeQueSTosome related. (693 aa)
T24B8.7Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (2938 aa)
usp-5Ubiquitin carboxyl-terminal hydrolase. (789 aa)
spe-48UBA domain-containing protein. (337 aa)
eel-1Enhancer of EfL-1 mutant phenotype. (4185 aa)
rad-23Uncharacterized protein. (323 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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