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| | C48D1.1 | Uncharacterized protein. (632 aa) |
| | smg-1 | Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2. (2322 aa) |
| | trr-1 | Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. (4064 aa) |
| | fhod-1 | Formin HOmology Domain. (1698 aa) |
| | C43H6.4 | Uncharacterized protein. (627 aa) |
| | ltah-1.1 | Aminopeptidase ltah-1.1; Aminopeptidase which preferentially removes N-terminal Arg and Lys residues from peptides and proteins. (609 aa) |
| | C37C3.2 | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). (436 aa) |
| | C35A5.8 | Uncharacterized protein. (1096 aa) |
| | hpo-27 | Uncharacterized protein. (1768 aa) |
| | gop-1 | Protein CLEC16A homolog; Regulator of mitophagy. (892 aa) |
| | hecd-1 | E3 ubiquitin-protein ligase hecd-1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins. Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision. Negatively regulates glp-1 activity in germline proliferation. May play a role in the formation of fibrous organelles, a hemidesmosome-like s [...] (2650 aa) |
| | gadr-2 | Uncharacterized protein. (732 aa) |
| | efr-3 | Protein EFR3 homolog; Belongs to the EFR3 family. (859 aa) |
| | puf-8 | PUM-HD domain-containing protein. (535 aa) |
| | C30G12.6 | Uncharacterized protein C30G12.6. (1100 aa) |
| | C27C7.7 | Uncharacterized protein. (348 aa) |
| | gbf-1 | SEC7 domain-containing protein. (1975 aa) |
| | mms-19 | MMS19_N domain-containing protein. (922 aa) |
| | rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa) |
| | C14C10.5 | Uncharacterized protein. (1908 aa) |
| | dohh-1 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. (298 aa) |
| | pptr-2 | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (607 aa) |
| | soap-1 | Sorting Of Apical Proteins. (2076 aa) |
| | daf-15 | Raptor_N domain-containing protein. (1800 aa) |
| | swsn-7 | SWI/SNF nucleosome remodeling complex component. (1244 aa) |
| | zyg-11 | Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment. (799 aa) |
| | cls-1 | Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division. (1378 aa) |
| | pro-2 | Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation. (715 aa) |
| | ced-5 | CED-5. (1781 aa) |
| | B0432.7 | Uncharacterized protein. (927 aa) |
| | wrm-1 | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] (796 aa) |
| | age-1 | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa) |
| | puf-7 | Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa) |
| | let-363 | Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] (2695 aa) |
| | vps-34 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa) |
| | che-12 | Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa) |
| | puf-12 | Pumilio domain-containing protein 12. (766 aa) |
| | vps-15 | Related to yeast Vacuolar Protein Sorting factor. (1354 aa) |
| | ZK792.5 | Uncharacterized protein. (645 aa) |
| | xpo-1 | Importin N-terminal domain-containing protein. (1080 aa) |
| | toe-1 | HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (1650 aa) |
| | dcaf-1 | DDB1- and CUL4-associated factor homolog 1; Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex. (1701 aa) |
| | cls-3 | Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (983 aa) |
| | ZC581.9 | Protein kinase domain-containing protein. (834 aa) |
| | ltah-1.2 | Leuk-A4-hydro_C domain-containing protein. (625 aa) |
| | Y92H12A.5 | DUF2428 domain-containing protein. (1378 aa) |
| | Y75B8A.24 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2106 aa) |
| | puf-11 | PUM-HD domain-containing protein. (505 aa) |
| | smg-3 | Suppressor with Morphological effect on Genitalia. (1144 aa) |
| | apb-1 | AP complex subunit beta. (955 aa) |
| | Y71A12B.12 | Uncharacterized protein. (721 aa) |
| | agef-1 | SEC7 domain-containing protein. (1594 aa) |
| | Y69A2AR.16 | Uncharacterized protein. (1120 aa) |
| | eel-1 | Enhancer of EfL-1 mutant phenotype. (4185 aa) |
| | Y67A10A.7 | Arm_2 domain-containing protein. (345 aa) |
| | Y55F3AM.5 | DUF2013 domain-containing protein. (365 aa) |
| | Y54H5A.2 | Uncharacterized protein. (375 aa) |
| | Y54E10A.11 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family. (1446 aa) |
| | Y53C12A.7 | Uncharacterized protein. (134 aa) |
| | mop-25.2 | MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis. (338 aa) |
| | Y52B11A.10 | MI domain-containing protein. (819 aa) |
| | frl-1 | FRL (Formin Related gene in Leukocytes) homolog. (1115 aa) |
| | gcn-1 | TOG domain-containing protein. (2651 aa) |
| | xpo-2 | Importin N-terminal domain-containing protein. (938 aa) |
| | Y48A6C.4 | Ipi1_N domain-containing protein. (365 aa) |
| | Y46E12BL.2 | NUC173 domain-containing protein. (1334 aa) |
| | puf-3 | PUM-HD domain-containing protein. (502 aa) |
| | pqn-85 | Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). (2203 aa) |
| | fcd-2 | FANCD2 (Fanconi's anemia defect) ortholog. (1440 aa) |
| | pro-3 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm (Probable). Required for normal somatic gonad development and for regulation of germline development and proliferation. (801 aa) |
| | dpy-28 | Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...] (1499 aa) |
| | Y38E10A.22 | Uncharacterized protein. (428 aa) |
| | copb-1 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (971 aa) |
| | hgap-1 | Rap-GAP domain-containing protein. (1306 aa) |
| | pad-1 | Protein pad-1; May be involved in protein traffic between late Golgi and early endosomes (By similarity). Essential for cell patterning during gastrulation. (2417 aa) |
| | hcp-6 | Condensin-2 complex subunit. (1758 aa) |
| | Y106G6G.2 | SEC7 domain-containing protein. (1655 aa) |
| | ced-12 | Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth. (738 aa) |
| | apg-1 | AP-1 complex subunit gamma. (829 aa) |
| | jac-1 | Juxtamembrane domain-associated catenin; May act as a positive modulator of hmr-1 function during epidermal morphogenesis. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the beta-catenin family. (1256 aa) |
| | cand-1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable). (1274 aa) |
| | apd-3 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa) |
| | pptr-1 | Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...] (542 aa) |
| | W07G4.3 | SCY1 Like pseudokinase. (820 aa) |
| | puf-9 | PUM-HD domain-containing protein. (703 aa) |
| | W04A4.5 | INTegrator complex Subunit homolog. (1071 aa) |
| | T28F4.4 | Uncharacterized protein. (929 aa) |
| | T28B8.4 | Uncharacterized protein. (1874 aa) |
| | T28B8.3 | DUF3437 domain-containing protein. (1879 aa) |
| | mop-25.3 | MO25-like protein 3; Belongs to the Mo25 family. (453 aa) |
| | zer-1 | Zyg eleven-related protein 1; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zer-1-cul-2-elc-1. (895 aa) |
| | sys-1 | SYmmetrical Sister cell hermaphrodite gonad defect. (811 aa) |
| | rpn-1 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa) |
| | chc-1 | Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa) |
| | apa-2 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa) |
| | ima-1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. (524 aa) |
| | T16G12.6 | Xpo1 domain-containing protein. (930 aa) |
| | ekl-6 | Uncharacterized protein. (964 aa) |
| | eif-3.K | Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (240 aa) |
| | T14G10.5 | Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (885 aa) |
| | vha-15 | Probable V-type proton ATPase subunit H 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (470 aa) |
| | T14B4.1 | SpoU_methylase domain-containing protein. (1225 aa) |
| | T08D2.8 | TOG domain-containing protein. (388 aa) |
| | sftb-1 | SF3b1 domain-containing protein. (1322 aa) |
| | T05H4.10 | NopRA1 domain-containing protein. (476 aa) |
| | apb-3 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (945 aa) |
| | R10H10.7 | Uncharacterized protein. (915 aa) |
| | cls-2 | Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development. (1023 aa) |
| | wapl-1 | Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene [...] (748 aa) |
| | imb-2 | Importin N-terminal domain-containing protein. (889 aa) |
| | mop-25.1 | MO25 (MOuse embryo scaffolding Protein) homolog. (636 aa) |
| | ifg-1 | MIF4G domain-containing protein. (1156 aa) |
| | M01E11.2 | DUF1716 domain-containing protein. (544 aa) |
| | K10B4.3 | Protein melted homolog; Belongs to the MELT/VEPH family. (871 aa) |
| | uso-1 | USO1 (Yeast transport protein) homolog. (941 aa) |
| | K05C4.7 | Armadillo repeat-containing protein 1. (289 aa) |
| | hmp-2 | Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. (704 aa) |
| | apr-1 | Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...] (1188 aa) |
| | vacl-14 | VAC (Yeast VACuole morphology)-Like. (694 aa) |
| | K04C2.2 | Uncharacterized protein. (990 aa) |
| | evl-14 | Uncharacterized protein. (1570 aa) |
| | fbf-1 | Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa) |
| | H04D03.3 | Uncharacterized protein. (409 aa) |
| | vps-35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (821 aa) |
| | F58D2.3 | Uncharacterized protein. (161 aa) |
| | F58B3.6 | Uncharacterized protein. (410 aa) |
| | ccpp-1 | Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells. (1015 aa) |
| | daam-1 | FH2 domain-containing protein. (987 aa) |
| | capg-2 | CAP-G condensin subunit. (1010 aa) |
| | marc-6 | RING-CH-type domain-containing protein. (1025 aa) |
| | puf-5 | Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (553 aa) |
| | F54A3.2 | Uncharacterized protein. (748 aa) |
| | tsr-1 | Xpo1 domain-containing protein. (829 aa) |
| | F53B3.3 | Uncharacterized protein. (689 aa) |
| | F53B2.5 | Uncharacterized protein. (476 aa) |
| | vha-18 | Probable V-type proton ATPase subunit H 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (451 aa) |
| | paa-1 | Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...] (590 aa) |
| | gadr-6 | Uncharacterized protein. (710 aa) |
| | gadr-3 | Gastrulation-defective protein 3. (710 aa) |
| | F46H5.4 | Uncharacterized protein; Belongs to the DOCK family. (2018 aa) |
| | F46C5.6 | Uncharacterized protein. (945 aa) |
| | insc-1 | INSCuteable (Drososphila asymmetric cell division protein) homolog. (715 aa) |
| | smk-1 | SMK-1 domain-containing protein. (1085 aa) |
| | piki-1 | Phosphatidylinositol 3-kinase piki-1; Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3- phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes; Belongs to the PI3/PI4-kinase family. (1607 aa) |
| | ncbp-1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa) |
| | ubr-5 | UBR E3 ubiquitin ligase homolog. (2944 aa) |
| | let-858 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family. (897 aa) |
| | F32H2.10 | Uncharacterized protein. (171 aa) |
| | ima-3 | Importin subunit alpha-3; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs. Necessary for correct nucleoporin localization within the germline. Belongs to the importin alpha family. (514 aa) |
| | vps-41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa) |
| | unc-45 | TPR_REGION domain-containing protein. (961 aa) |
| | capg-1 | Condensin complex subunit capg-1; Member of two distinct condensin I complexes, the condensin I complex and the condensin I-like dosage compensation complex. The condensin I complex is required for conversion of interphase chromatin into mitotic-like condensed chromosomes and for chromosome segregation in meiosis and mitosis. As a member of the condensin I complex, further controls crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Regulatory subunit of the condensin I-like dosage compens [...] (1153 aa) |
| | rict-1 | RICTOR_V domain-containing protein. (1580 aa) |
| | imb-1 | Importin N-terminal domain-containing protein. (896 aa) |
| | ima-2 | Importin subunit alpha-2; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). (531 aa) |
| | F25G6.9 | Uncharacterized protein. (1373 aa) |
| | unc-80 | Protein unc-80; Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane. (3263 aa) |
| | F23B12.7 | Uncharacterized protein F23B12.7; Belongs to the CBF/MAK21 family. (953 aa) |
| | zyg-9 | Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. (1415 aa) |
| | fbf-2 | Fem-3 mRNA-binding factor 2; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the d [...] (632 aa) |
| | sax-2 | Sensory AXon guidance. (2886 aa) |
| | scc-3 | Cohesin subunit scc-3; Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Has a role in stabilization of homologous chromosome associations during meiotic syn [...] (1096 aa) |
| | utp-20 | DRIM domain-containing protein. (2613 aa) |
| | rme-8 | J domain-containing protein. (2279 aa) |
| | puf-6 | Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa) |
| | tbcd-1 | Tubulin-specific chaperone D; Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization ; Belongs to the TBCD family. (1232 aa) |
| | ppfr-1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex. (1562 aa) |
| | btf-1 | BTAF (TBP-associated factor) homolog. (1649 aa) |
| | tir-1 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa) |
| | cyk-1 | CYtoKinesis defect. (1437 aa) |
| | mon-2 | Monensin-resistant homolog 2; May be required for traffic between late Golgi and early endosomes. (1648 aa) |
| | sel-2 | Putative neurobeachin homolog; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells. (2507 aa) |
| | kap-1 | Kinesin-Associated Protein. (696 aa) |
| | F01F1.3 | Uncharacterized protein. (248 aa) |
| | eif-2Bepsilon | W2 domain-containing protein. (666 aa) |
| | D2045.2 | Uncharacterized protein. (1810 aa) |
| | D2030.3 | Uncharacterized protein. (508 aa) |
| | nekl-4 | Serine/threonine-protein kinase D1044.8. (981 aa) |
| | D1043.1 | INTegrator complex Subunit homolog. (910 aa) |
| | bar-1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] (811 aa) |
| | imb-3 | Importin N-terminal domain-containing protein. (1092 aa) |
| | xpo-3 | Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (952 aa) |
