STRINGSTRING
jmjd-1.1 jmjd-1.1 C16A11.4 C16A11.4 C16A11.3 C16A11.3 taf-3 taf-3 phf-14 phf-14 phf-15 phf-15 set-26 set-26 ing-3 ing-3 Y43H11AL.1 Y43H11AL.1 athp-2 athp-2 F53H1.4 F53H1.4 nra-3 nra-3 lin-49 lin-49 jmjd-1.2 jmjd-1.2 nurf-1 nurf-1 let-418 let-418 set-9 set-9 athp-1 athp-1 ash-2 ash-2 phf-30 phf-30 chd-3 chd-3 lin-59 lin-59 phf-33 phf-33
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
jmjd-1.1JmjC domain-containing protein. (548 aa)
C16A11.4SPK domain-containing protein. (527 aa)
C16A11.3SPK domain-containing protein. (299 aa)
taf-3PHD-type domain-containing protein. (1007 aa)
phf-14PHd Finger family. (599 aa)
phf-15PHd Finger family. (741 aa)
set-26Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...] (1645 aa)
ing-3Inhibitor of growth protein. (490 aa)
Y43H11AL.1PHD-type domain-containing protein. (490 aa)
athp-2AT Hook plus PHD finger transcription factor. (1427 aa)
F53H1.4PHD-type domain-containing protein. (1275 aa)
nra-3PHD-type domain-containing protein. (925 aa)
lin-49Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1042 aa)
jmjd-1.2Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (929 aa)
nurf-1Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa)
let-418Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa)
set-9Histone-lysine N-methyltransferase set-9; Histone methyltransferase (By similarity). Might play a role in transcriptional regulation. Together with set-26, negatively regulates lifespan in a germline-independent, partially daf- 16-dependent fashion. Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline ; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1623 aa)
athp-1AT Hook plus PHD finger transcription factor. (1150 aa)
ash-2Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (575 aa)
phf-30PHD-type domain-containing protein. (234 aa)
chd-3Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa)
lin-59Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa)
phf-33PHD-type domain-containing protein. (650 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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