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| | gspd-1 | Glucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. (522 aa) |
| | B0250.5 | Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. (299 aa) |
| | B0272.3 | Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (309 aa) |
| | acly-2 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1099 aa) |
| | C01F1.3 | NAD(P)-bd_dom domain-containing protein. (631 aa) |
| | C01G12.5 | Uncharacterized protein. (279 aa) |
| | dhs-1 | DeHydrogenases, Short chain. (323 aa) |
| | C04F6.7 | Uncharacterized oxidoreductase dhs-27. (447 aa) |
| | sucl-1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (322 aa) |
| | stdh-1 | Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (314 aa) |
| | stdh-3 | Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa) |
| | C06B8.3 | Uncharacterized protein. (162 aa) |
| | C06E4.3 | Uncharacterized protein. (277 aa) |
| | C06E4.6 | Uncharacterized protein. (274 aa) |
| | dhs-16 | 3 beta-hydroxysteroid dehydrogenase dhs-16; 3 beta-hydroxysteroid dehydrogenase that converts 3 beta- hydroxysteroids to 3-ketosteroids, an essential step in the production of Delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa) |
| | dhs-22 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (333 aa) |
| | nnt-1 | Nicotinamide Nucleotide Transhydrogenase. (1041 aa) |
| | dhs-6 | SCP2 domain-containing protein. (418 aa) |
| | C27D8.4 | Epimerase domain-containing protein. (338 aa) |
| | ech-1.1 | Enoyl-CoA Hydratase. (755 aa) |
| | C30G12.2 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa) |
| | Y37E11AM.3 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (347 aa) |
| | dhs-9 | DeHydrogenases, Short chain. (319 aa) |
| | mecr-1 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (344 aa) |
| | W03F9.9 | Uncharacterized protein. (280 aa) |
| | decr-1.2 | Probable 2,4-dienoyl-CoA reductase decr-1.2; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. (309 aa) |
| | inos-1 | Inos-1-P_synth domain-containing protein. (525 aa) |
| | dhs-30 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa) |
| | T25G12.13 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | T25B9.9 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | dhs-19 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (307 aa) |
| | gpd-1 | Glyceraldehyde-3-phosphate dehydrogenase 1. (341 aa) |
| | ech-1.2 | Enoyl-CoA Hydratase. (781 aa) |
| | dhs-4 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa) |
| | decr-1.3 | Probable 2,4-dienoyl-CoA reductase 3; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. (309 aa) |
| | dhs-31 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa) |
| | qdpr-1 | Quinoid DihydroPteridine Reductase. (236 aa) |
| | dhs-3 | Protein dhs-3; May play a role in lipid droplet formation. May modulate triglyceride levels; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa) |
| | perm-1 | PERMeable eggshell. (486 aa) |
| | T01G6.10 | Uncharacterized protein. (275 aa) |
| | T01G6.1 | Uncharacterized protein. (279 aa) |
| | dhs-21 | L-xylulose reductase; Catalyzes the NADPH-dependent reduction of L-xylulose, D- xylulose, L-(+) erythrulose, D-erythrose, D-threose, L-ribulose, 1,4- dibromo-2,3-butanedione and 2,3-heptanedione. Also active against isatin, 9,10-phenanthrenequinone, menadione, 2,3- hexaenadione and 3,4-hexahenadione. No activity observed when tested using NADH rather than NADPH. (251 aa) |
| | R119.3 | Uncharacterized protein. (253 aa) |
| | hacd-1 | Hydroxy-Acyl-CoA Dehydrogenase. (299 aa) |
| | dhs-23 | DeHydrogenases, Short chain. (277 aa) |
| | R05D8.9 | Uncharacterized protein. (281 aa) |
| | dhs-14 | DeHydrogenases, Short chain. (279 aa) |
| | R05D8.7 | Uncharacterized protein. (280 aa) |
| | dhs-15 | DeHydrogenases, Short chain. (278 aa) |
| | R04B5.6 | PKS_ER domain-containing protein. (347 aa) |
| | R04B5.5 | PKS_ER domain-containing protein. (347 aa) |
| | aass-1 | AminoAdipate-Semialdehyde Synthase homolog. (952 aa) |
| | ger-1 | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (315 aa) |
| | M153.1 | Uncharacterized protein. (293 aa) |
| | M106.3 | PKS_ER domain-containing protein. (373 aa) |
| | dhs-28 | SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa) |
| | gmd-2 | GDP-mannose 4,6 dehydratase 2; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (382 aa) |
| | rad-8 | Reticulon-4-interacting protein 1, mitochondrial; Plays a role in oxygen metabolism in the mitochondria by regulating the levels of reactive oxygen species (ROS) thereby conferring resistance to oxidative stress. Involved in resistance to P.aeruginosa PA14 infection. Regulates lifespan. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (366 aa) |
| | dhs-5 | Uncharacterized oxidoreductase dhs-5. (378 aa) |
| | F55G1.9 | Putative pyrroline-5-carboxylate reductase. (299 aa) |
| | drd-5 | Dietary restriction down regulated. (331 aa) |
| | dhs-2 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (368 aa) |
| | dhrs-4 | Dehydrogenase/reductase SDR family member 4; Catalyzes the reduction of isatin, 4-oxonon-2-enal, 9,10- phenanthrenequinone, menadione, 2,3-hexaenadione, 3,4-hexanedione and 2,3-heptanedione. (260 aa) |
| | F54C8.1 | Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (298 aa) |
| | F53C11.3 | Uncharacterized oxidoreductase F53C11.3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. (313 aa) |
| | F53B1.4 | NAD(P)-bd_dom domain-containing protein. (342 aa) |
| | ctbp-1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. (727 aa) |
| | gpdh-1 | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (374 aa) |
| | mdh-1 | Malate dehydrogenase. (336 aa) |
| | F39B2.3 | PKS_ER domain-containing protein. (328 aa) |
| | dhs-13 | DeHydrogenases, Short chain. (257 aa) |
| | dhs-20 | DeHydrogenases, Short chain. (342 aa) |
| | gpd-4 | Glyceraldehyde-3-phosphate dehydrogenase 4. (341 aa) |
| | fasn-1 | Carrier domain-containing protein. (2613 aa) |
| | F32A5.8 | Uncharacterized protein. (257 aa) |
| | dhs-17 | DeHydrogenases, Short chain. (286 aa) |
| | sqv-4 | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (481 aa) |
| | F28H7.2 | Uncharacterized protein. (284 aa) |
| | dhs-29 | DeHydrogenases, Short chain. (427 aa) |
| | F26D2.15 | Uncharacterized protein. (279 aa) |
| | stdh-4 | Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (317 aa) |
| | F25D1.5 | Uncharacterized protein. (277 aa) |
| | sucl-2 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (321 aa) |
| | F22F7.2 | Sacchrp_dh_NADP domain-containing protein. (422 aa) |
| | ldp-1 | Lipid droplet localized protein; Belongs to the saccharopine dehydrogenase family. (426 aa) |
| | F21C10.10 | Uncharacterized protein. (226 aa) |
| | mdh-2 | Probable malate dehydrogenase, mitochondrial. (341 aa) |
| | F20G2.2 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | F20G2.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | F17C8.9 | Uncharacterized protein. (271 aa) |
| | ldh-1 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. LDH family. (336 aa) |
| | F13D11.4 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (343 aa) |
| | F12E12.11 | Uncharacterized protein. (280 aa) |
| | stdh-2 | Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa) |
| | dhs-25 | DeHydrogenases, Short chain. (248 aa) |
| | F08F3.4 | Epimerase domain-containing protein. (358 aa) |
| | F02C12.2 | Uncharacterized protein. (278 aa) |
| | ard-1 | Alcohol/Ribitol Dehydrogenase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa) |
| | ech-9 | Enoyl-CoA Hydratase. (434 aa) |
| | ech-8 | Enoyl-CoA Hydratase. (437 aa) |
| | dhs-7 | DeHydrogenases, Short chain. (329 aa) |
| | E04F6.15 | Uncharacterized protein. (319 aa) |
| | DC2.5 | Uncharacterized protein. (337 aa) |
| | sqv-1 | NAD(P)-bd_dom domain-containing protein. (467 aa) |
| | D2063.1 | PKS_ER domain-containing protein; Belongs to the zinc-containing alcohol dehydrogenase family. (350 aa) |
| | D1054.8 | Uncharacterized protein. (278 aa) |
| | acly-1 | Probable ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1106 aa) |
| | let-767 | Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (337 aa) |
| | C55A6.7 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa) |
| | C55A6.6 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa) |
| | sdz-8 | SKN-1 Dependent Zygotic transcript. (250 aa) |
| | C55A6.4 | Uncharacterized protein. (250 aa) |
| | C55A6.3 | Uncharacterized protein. (250 aa) |
| | bre-1 | GDP-mannose 4,6 dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds. Has a role in determining brood size. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (399 aa) |
| | gale-1 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (349 aa) |
| | dhs-18 | DeHydrogenases, Short chain. (293 aa) |
| | pks-1 | PolyKetide Synthase. (7752 aa) |
| | C33F10.14 | Semialdhyde_dh domain-containing protein. (218 aa) |
| | C33E10.10 | Uncharacterized protein. (135 aa) |
| | C31C9.2 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa) |
| | C32D5.12 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (357 aa) |
| | sodh-2 | Alcohol dehydrogenase 2; Belongs to the zinc-containing alcohol dehydrogenase family. (351 aa) |
| | sodh-1 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. (349 aa) |
| | gpdh-2 | Probable glycerol-3-phosphate dehydrogenase 2. (392 aa) |
| | K10H10.6 | Uncharacterized protein. (315 aa) |
| | dhs-8 | DeHydrogenases, Short chain. (379 aa) |
| | gpd-2 | Glyceraldehyde-3-phosphate dehydrogenase 2. (341 aa) |
| | gpd-3 | Glyceraldehyde-3-phosphate dehydrogenase 3. (341 aa) |
| | dhs-12 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa) |
| | dao-3 | Dauer or Aging adult Overexpression. (303 aa) |
| | ahcy-1 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. (437 aa) |
| | H24K24.3 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Plays a role in the calcium flux to the cytoplasm in the ASJ sensory neurons upon removal of a nitric oxide stimulus. (386 aa) |
| | H04M03.3 | Uncharacterized protein. (333 aa) |
| | F59E11.2 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa) |
| | ZK829.7 | PKS_ER domain-containing protein. (372 aa) |
| | gdh-1 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (536 aa) |
| | ZK829.1 | Uncharacterized protein. (284 aa) |
| | dhs-26 | DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa) |
| | ZK697.14 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | hsd-2 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (374 aa) |
| | hsd-3 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (359 aa) |
| | fard-1 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (536 aa) |
| | Y71G12B.6 | NAD(P)-bd_dom domain-containing protein. (383 aa) |
| | Y71F9B.9 | Uncharacterized protein. (315 aa) |
| | hsd-1 | 3Beta_HSD domain-containing protein. (462 aa) |
| | dhs-24 | DeHydrogenases, Short chain. (384 aa) |
| | Y53G8AL.2 | NAD(P)-bd_dom domain-containing protein. (431 aa) |
| | slo-1 | Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa) |
| | men-1 | Malic enzyme. (620 aa) |
| | Y48A6B.9 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (346 aa) |
| | Y47G6A.22 | Uncharacterized protein. (254 aa) |
| | Y47G6A.21 | Uncharacterized protein. (255 aa) |
| | dhs-11 | DeHydrogenases, Short chain. (244 aa) |
