STRINGSTRING
nas-36 nas-36 unc-5 unc-5 adt-1 adt-1 C11H1.5 C11H1.5 nas-37 nas-37 C27A7.8 C27A7.8 C27A7.9 C27A7.9 C36B7.5 C36B7.5 mig-6 mig-6 D1022.2 D1022.2 mig-21 mig-21 adt-2 adt-2 F09F9.4 F09F9.4 spon-1 spon-1 F11C7.2 F11C7.2 F11C7.6 F11C7.6 F11C7.7 F11C7.7 F14H12.3 F14H12.3 F15B9.8 F15B9.8 F23H12.5 F23H12.5 gon-1 gon-1 F35C11.7 F35C11.7 madd-4 madd-4 fig-1 fig-1 nas-38 nas-38 H42K12.3 H42K12.3 nas-33 nas-33 dpy-31 dpy-31 R17.3 R17.3 adt-3 adt-3 T21B6.3 T21B6.3 Y64G10A.1 Y64G10A.1 Y67A10A.11 Y67A10A.11 Y73E7A.8 Y73E7A.8 Y8A9A.2 Y8A9A.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nas-36Zinc metalloproteinase nas-36; Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. (617 aa)
unc-5Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. (947 aa)
adt-1A disintegrin and metalloproteinase with thrombospondin motifs adt-1; Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle. (1461 aa)
C11H1.5Uncharacterized protein. (528 aa)
nas-37Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape. (765 aa)
C27A7.8Uncharacterized protein. (96 aa)
C27A7.9Uncharacterized protein. (95 aa)
C36B7.5Uncharacterized protein. (1148 aa)
mig-6Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. (2167 aa)
D1022.2Uncharacterized protein. (128 aa)
mig-21Abnormal cell migration protein 21; Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left- side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration. (313 aa)
adt-2A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. (1020 aa)
F09F9.4Uncharacterized protein. (654 aa)
spon-1SPONdin (Extracellular matrix glycoprotein) family. (819 aa)
F11C7.2Uncharacterized protein. (152 aa)
F11C7.6Uncharacterized protein. (133 aa)
F11C7.7Uncharacterized protein. (114 aa)
F14H12.3Uncharacterized protein. (257 aa)
F15B9.8Uncharacterized protein. (168 aa)
F23H12.5Uncharacterized protein. (802 aa)
gon-1A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] (2165 aa)
F35C11.7Uncharacterized protein. (125 aa)
madd-4Protein madd-4; Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1. Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms. In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis. The unc-40 cor [...] (1045 aa)
fig-1Uncharacterized protein. (2892 aa)
nas-38Zinc metalloproteinase nas-38; Metalloprotease. (745 aa)
H42K12.3Uncharacterized protein. (522 aa)
nas-33Zinc metalloproteinase nas-33; Metalloprotease. (644 aa)
dpy-31Zinc metalloproteinase dpy-31; Metalloprotease which cleaves the carboxyl terminus of procollagens, such as sqt-3, to mature collagens (By similarity). Involved in cuticular collagen maturation. (592 aa)
R17.3SMB domain-containing protein. (440 aa)
adt-3Peptidase M12B domain-containing protein. (940 aa)
T21B6.3Apple domain-containing protein. (821 aa)
Y64G10A.1Uncharacterized protein. (302 aa)
Y67A10A.11Uncharacterized protein. (292 aa)
Y73E7A.8Uncharacterized protein. (680 aa)
Y8A9A.2Uncharacterized protein. (1359 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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