STRINGSTRING
sma-1 sma-1 chdp-1 chdp-1 lrch-1 lrch-1 cpn-3 cpn-3 T15B12.1 T15B12.1 pat-6 pat-6 ebp-2 ebp-2 atn-1 atn-1 plst-1 plst-1 grdn-1 grdn-1 ebp-1 ebp-1 fln-1 fln-1 Y73B3B.1 Y73B3B.1 vab-10 vab-10 zyg-12 zyg-12 anc-1 anc-1 fln-2 fln-2 vav-1 vav-1 aspm-1 aspm-1 cpn-2 cpn-2 D2096.11 D2096.11 pes-7 pes-7 dys-1 dys-1 ehbp-1 ehbp-1 F26F4.5 F26F4.5 ptrn-1 ptrn-1 cpn-1 cpn-1 unc-53 unc-53 cpn-4 cpn-4 unc-70 unc-70 M116.5 M116.5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sma-1SMAll. (4166 aa)
chdp-1Calponin-homology (CH) domain-containing protein. (338 aa)
lrch-1Calponin-homology (CH) domain-containing protein. (638 aa)
cpn-3Calponin-homology (CH) domain-containing protein. (142 aa)
T15B12.1Calponin-homology (CH) domain-containing protein. (432 aa)
pat-6Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa)
ebp-2Microtubule End Binding Protein. (299 aa)
atn-1AcTiniN. (920 aa)
plst-1PLaSTin (Actin bundling protein) homolog. (370 aa)
grdn-1Girdin homolog; Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10. Belongs to the CCDC88 family. (1319 aa)
ebp-1Microtubule End Binding Protein. (316 aa)
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)
Y73B3B.1Calponin-homology (CH) domain-containing protein. (376 aa)
vab-10GAR domain-containing protein. (5059 aa)
zyg-12Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. (777 aa)
anc-1Nuclear anchorage protein 1; Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron. Belongs to the nesprin family. (8545 aa)
fln-2FiLamiN (Actin binding protein) homolog. (3672 aa)
vav-1Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa)
aspm-1Calponin-homology (CH) domain-containing protein. (1186 aa)
cpn-2Transgelin; Belongs to the calponin family. (203 aa)
D2096.11GAR domain-containing protein. (727 aa)
pes-7Patterned Expression Site. (1391 aa)
dys-1Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
F26F4.5Calponin-homology (CH) domain-containing protein. (465 aa)
ptrn-1Patronin (microtubule-binding protein) homolog; Required for microtubule stability and anchorage by binding to the minus ends of microtubules. Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis. Promotes microtubule stability and polymerization in neurons. Involved in the maintenance of neurite morphology in ALM and PLM neurons. May play a role in synaptic protein localization in the PLM neuron. May act upstream of dlk-1 in neuronal regeneration. Play [...] (1112 aa)
cpn-1Calponin-homology (CH) domain-containing protein. (192 aa)
unc-53Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals. (1654 aa)
cpn-4Calponin-homology (CH) domain-containing protein. (154 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
M116.5Uncharacterized protein. (1020 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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