STRINGSTRING
T25G3.4 T25G3.4 acdh-3 acdh-3 acdh-8 acdh-8 nuo-4 nuo-4 fmo-5 fmo-5 acox-1.6 acox-1.6 acox-3 acox-3 F56C11.3 F56C11.3 bli-3 bli-3 xdh-1 xdh-1 F54D5.7 F54D5.7 fmo-4 fmo-4 mtcu-2 mtcu-2 F47B7.2 F47B7.2 F35G2.1 F35G2.1 acdh-9 acdh-9 F27D4.1 F27D4.1 ddo-3 ddo-3 ddo-2 ddo-2 F15E6.6 F15E6.6 acox-1.4 acox-1.4 acox-1.3 acox-1.3 acox-1.2 acox-1.2 acox-1.1 acox-1.1 acdh-12 acdh-12 acdh-1 acdh-1 acox-1.5 acox-1.5 ddo-1 ddo-1 C46H11.2 C46H11.2 gsr-1 gsr-1 acdh-5 acdh-5 C34C6.4 C34C6.4 sdha-2 sdha-2 dpyd-1 dpyd-1 acdh-2 acdh-2 C15B12.1 C15B12.1 trxr-1 trxr-1 mthf-1 mthf-1 let-721 let-721 sdha-1 sdha-1 acdh-10 acdh-10 acdh-4 acdh-4 T10H10.2 T10H10.2 acdh-7 acdh-7 coq-6 coq-6 ero-1 ero-1 fre-1 fre-1 fmo-3 fmo-3 spr-5 spr-5 acdh-11 acdh-11 acdh-6 acdh-6 ivd-1 ivd-1 C01H6.4 C01H6.4 mtrr-1 mtrr-1 prdh-1 prdh-1 Y45G12B.3 Y45G12B.3 ads-1 ads-1 Y52B11A.3 Y52B11A.3 Y62E10A.6 Y62E10A.6 daao-1 daao-1 cblc-1 cblc-1 trxr-2 trxr-2 lsd-1 lsd-1 hpo-19 hpo-19 T05H4.4 T05H4.4 flad-1 flad-1 amx-1 amx-1 kmo-1 kmo-1 dld-1 dld-1 emb-8 emb-8 fmo-2 fmo-2 fmo-1 fmo-1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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T25G3.4Probable glycerol-3-phosphate dehydrogenase, mitochondrial. (722 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
acdh-8Acyl CoA DeHydrogenase. (412 aa)
nuo-4NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (436 aa)
fmo-5Dimethylaniline monooxygenase [N-oxide-forming]. (518 aa)
acox-1.6Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
acox-3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
F56C11.3Sulfhydryl oxidase. (161 aa)
bli-3Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...] (1497 aa)
xdh-1Xanthine DeHydrogenase homolog. (1358 aa)
F54D5.7Probable glutaryl-CoA dehydrogenase, mitochondrial. (409 aa)
fmo-4Dimethylaniline monooxygenase [N-oxide-forming]. (568 aa)
mtcu-2Protein MTO1 homolog, mitochondrial; Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Belongs to the MnmG family. (638 aa)
F47B7.2Sulfhydryl oxidase. (678 aa)
F35G2.1Sulfhydryl oxidase. (601 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
F27D4.1Probable electron transfer flavoprotein subunit alpha, mitochondrial; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (332 aa)
ddo-3D-aspartate oxidase 3; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Has no activity towards L-amino acids or N-methyl-L-aspartic acid. May play a role in the egg-laying events and maturation processes of the reproductive organs. (383 aa)
ddo-2D-aspartate oxidase 2; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells. (334 aa)
F15E6.6Uncharacterized protein. (1256 aa)
acox-1.4Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
acox-1.3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
acox-1.2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
acox-1.1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
acox-1.5Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (659 aa)
ddo-1D-aspartate oxidase 1; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells. Belongs to the DAMOX/DASOX family. (334 aa)
C46H11.2Flavin-containing monooxygenase. (408 aa)
gsr-1Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. (473 aa)
acdh-5Acyl CoA DeHydrogenase. (442 aa)
C34C6.4Uncharacterized protein. (599 aa)
sdha-2Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa)
dpyd-1Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil. (1059 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
C15B12.1Putative sarcosine oxidase; Belongs to the MSOX/MTOX family. (384 aa)
trxr-1Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting. (667 aa)
mthf-1Probable methylenetetrahydrofolate reductase. (663 aa)
let-721Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family. (597 aa)
sdha-1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (646 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
T10H10.2Sulfhydryl oxidase. (574 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
coq-6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6; Belongs to the UbiH/COQ6 family. (451 aa)
ero-1Endoplasmic reticulum oxidoreductin-1; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). (513 aa)
fre-1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. (588 aa)
fmo-3Dimethylaniline monooxygenase [N-oxide-forming]. (512 aa)
spr-5Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa)
acdh-11Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. (617 aa)
acdh-6Probable acyl-CoA dehydrogenase 6; Belongs to the acyl-CoA dehydrogenase family. (408 aa)
ivd-1Isovaleryl-CoA dehydrogenase. (419 aa)
C01H6.4Flavin-containing monooxygenase. (405 aa)
mtrr-1Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state. (682 aa)
prdh-1Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate (By similarity). Through proline catabolism, promotes reactive oxygen species (ROS) production and the transcription of skn-1 target genes in response to bacterial infection by P.aeruginosa. (616 aa)
Y45G12B.3L-2-hydroxyglutarate dehydrogenase, mitochondrial. (433 aa)
ads-1Alkyldihydroxyacetonephosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (597 aa)
Y52B11A.3Uncharacterized protein. (552 aa)
Y62E10A.6NADPH:adrenodoxin oxidoreductase, mitochondrial. (458 aa)
daao-1D-amino-acid oxidase; Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine. Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups. Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid. May play a role in egg-laying events and early development. (322 aa)
cblc-1MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] (272 aa)
trxr-2Probable glutathione reductase 2; Maintains high levels of reduced glutathione in the cytosol. (503 aa)
lsd-1Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa)
hpo-19NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (309 aa)
T05H4.4NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (303 aa)
flad-1Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the N-terminal section; belongs to the MoaB/Mog family. (519 aa)
amx-1Amine oxidase family member 1. (824 aa)
kmo-1Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa)
dld-1Dihydrolipoyl dehydrogenase, mitochondrial. (495 aa)
emb-8NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (662 aa)
fmo-2Dimethylaniline monooxygenase [N-oxide-forming]. (529 aa)
fmo-1Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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