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| | suox-1 | Cytochrome b5 heme-binding domain-containing protein. (541 aa) |
| | pxn-1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa) |
| | elpc-3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (547 aa) |
| | glb-1 | Globin-like protein; May be a globin and may play a role in oxygen transport. (159 aa) |
| | rbr-2 | Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation. (1477 aa) |
| | ZK550.6 | Probable phytanoyl-CoA dioxygenase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. (312 aa) |
| | aco-1 | Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (887 aa) |
| | mlt-7 | Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens. (724 aa) |
| | cyp-44A1 | Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (489 aa) |
| | cyp-13A10 | Putative cytochrome P450 CYP13A10; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (519 aa) |
| | tph-1 | BH4_AAA_HYDROXYL_2 domain-containing protein. (532 aa) |
| | clk-1 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner; Belongs to the COQ7 family. (187 aa) |
| | cyc-2.2 | Probable cytochrome c 2.2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (123 aa) |
| | Y92H12BL.1 | Threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Belongs to the methylthiotransferase family. CDKAL1 subfamily. (425 aa) |
| | cyp-42A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (511 aa) |
| | smf-3 | NRAMP-like transporter smf-3; Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron. Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+). (560 aa) |
| | cyp-32B1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (516 aa) |
| | dpy-21 | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture. Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression. Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development. X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC). Requ [...] (1641 aa) |
| | glb-32 | GLOBIN domain-containing protein; Belongs to the globin family. (257 aa) |
| | glb-34 | GLOBIN domain-containing protein; Belongs to the globin family. (199 aa) |
| | oxy-4 | Probable cytosolic Fe-S cluster assembly factor oxy-4; Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity); Belongs to the NARF family. (457 aa) |
| | ctl-1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa) |
| | ctl-2 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. (500 aa) |
| | ctl-3 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa) |
| | Y52B11A.3 | Uncharacterized protein. (552 aa) |
| | glrx-5 | Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily. (142 aa) |
| | cyp-33C11 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | jmjd-2 | Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. (922 aa) |
| | dpy-18 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (559 aa) |
| | pola-1 | DNA polymerase. (1456 aa) |
| | bcmo-1 | Beta-Carotene 15,15'-MonoOxygenase. (529 aa) |
| | cyp-29A3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (503 aa) |
| | cox-5A | Cytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (174 aa) |
| | glb-30 | GLOBIN domain-containing protein; Belongs to the globin family. (272 aa) |
| | cyp-31A3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | cyp-33D3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | glb-28 | GLOBIN domain-containing protein; Belongs to the globin family. (217 aa) |
| | Y105C5B.9 | Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog; Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). Belongs to the PhyH family. PHYHD1 subfamily. (288 aa) |
| | nduf-7 | Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (199 aa) |
| | W07E11.1 | Glutamine amidotransferase type-2 domain-containing protein. (2185 aa) |
| | hgo-1 | Homogentisate 1,2-dioxygenase. (437 aa) |
| | pri-2 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (503 aa) |
| | cytb-5.2 | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (141 aa) |
| | mfn-1 | Mitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa) |
| | jmjc-1 | Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress; Belongs to the ROX family. NO66 subfamily. (748 aa) |
| | jhdm-1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. (1149 aa) |
| | glb-26 | Globin-like protein 26; Plays a role in electron transport. Utilizes the bis-histidyl hexacoordinated complex with iron to transfer electrons to cytochrome c and molecular oxygen. Plays a regulatory role in the periodicity of the defecation cycle under oxidative stress conditions. Not involved in imparting protection against general conditions of oxidative stress. May participate in redox reactions under anaerobic conditions. (183 aa) |
| | hpd-1 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. (393 aa) |
| | T20H4.5 | Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (212 aa) |
| | T20B12.7 | Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (238 aa) |
| | T19C4.5 | GLOBIN domain-containing protein; Belongs to the globin family. (360 aa) |
| | daf-9 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] (572 aa) |
| | cyp-34A2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (502 aa) |
| | cyp-34A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (504 aa) |
| | cyp-13A1 | Putative cytochrome P450 CYP13A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (519 aa) |
| | cyp-13A2 | Putative cytochrome P450 CYP13A2; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (515 aa) |
| | cyp-13A3 | Putative cytochrome P450 CYP13A3; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (520 aa) |
| | cyp-13A8 | Putative cytochrome P450 CYP13A8; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (509 aa) |
| | cyp-13A6 | Putative cytochrome P450 CYP13A6; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (518 aa) |
| | cyp-13A5 | Putative cytochrome P450 CYP13A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (520 aa) |
| | cyp-13A7 | Putative cytochrome P450 CYP13A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (518 aa) |
| | cyp-13A4 | Putative cytochrome P450 CYP13A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (520 aa) |
| | cyp-34A4 | Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa) |
| | gcy-31 | Soluble guanylate cyclase gcy-31; Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis. (702 aa) |
| | mev-1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Mediates resistance to enteropathogenic E.coli infection. Belongs to the cytochrome b560 family. (182 aa) |
| | cchl-1 | Probable cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (280 aa) |
| | glb-25 | GLOBIN domain-containing protein; Belongs to the globin family. (191 aa) |
| | gcy-35 | Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...] (688 aa) |
| | ppat-1 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa) |
| | glb-23 | GLOBIN domain-containing protein; Belongs to the globin family. (342 aa) |
| | nth-1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (298 aa) |
| | glb-21 | GLOBIN domain-containing protein; Belongs to the globin family. (196 aa) |
| | cyp-33C8 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-14A4 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (491 aa) |
| | ctc-1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (525 aa) |
| | ctb-1 | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c (By similarity). Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (370 aa) |
| | gcy-34 | Soluble guanylate cyclase gcy-34; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (686 aa) |
| | M01F1.3 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. (354 aa) |
| | cyp-35A3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | gas-1 | Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (482 aa) |
| | cyp-14A3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (498 aa) |
| | cyp-14A2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (492 aa) |
| | cyp-14A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (491 aa) |
| | pah-1 | Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan. Plays a role in the biosynthesis of a melanin-like cuticle pigment. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (457 aa) |
| | cyp-35A5 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-35B1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-35B2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-35B3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-13B2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (511 aa) |
| | haao-1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (281 aa) |
| | cyp-33D1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (492 aa) |
| | dph-3 | DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). (80 aa) |
| | cyp-31A2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | frh-1 | Frataxin, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Belongs to the frataxin family. (136 aa) |
| | gcy-33 | Soluble guanylate cyclase gcy-33; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (947 aa) |
| | cdo-1 | Cysteine dioxygenase 1; Belongs to the cysteine dioxygenase family. (190 aa) |
| | glb-19 | GLOBIN domain-containing protein; Belongs to the globin family. (223 aa) |
| | F55H2.5 | Putative cytochrome b561. (266 aa) |
| | xdh-1 | Xanthine DeHydrogenase homolog. (1358 aa) |
| | aco-2 | Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (777 aa) |
| | F53F4.10 | Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (239 aa) |
| | bcmo-2 | Beta-Carotene 15,15'-MonoOxygenase. (530 aa) |
| | let-268 | Multifunctional procollagen lysine hydroxylase and glycosyltransferase; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Catalyzes the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in type IV collagens (By similarity). Transfers galactose onto hydroxylysine groups, giving rise to galactosyl 5- hydroxylysine (By similarity). Catalyzes the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV coll [...] (730 aa) |
| | glb-18 | GLOBIN domain-containing protein; Belongs to the globin family. (242 aa) |
| | glb-17 | GLOBIN domain-containing protein; Belongs to the globin family. (218 aa) |
| | F49E2.1 | Cyclic pyranopterin monophosphate synthase; Isoform mocs1a and isoform mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). mocs1a catalyzes the cyclization of GTP to (8S)- 3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. (600 aa) |
| | skpo-1 | Peroxidase skpo-1; Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. Belongs to the peroxidase family. XPO subfamily. (655 aa) |
| | F49E10.2 | Uncharacterized protein. (842 aa) |
| | cyp-33C4 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (493 aa) |
| | F42F12.4 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (178 aa) |
| | cyp-33E2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | sdhb-1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (298 aa) |
| | cyp-33C6 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-33C3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (500 aa) |
| | cyp-33C5 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-33C7 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | phy-2 | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (539 aa) |
| | F35C8.5 | Cholesterol 25-hydroxylase-like protein; Probable sterol desaturase. (300 aa) |
| | pole-1 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa) |
| | sdhd-1 | Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (145 aa) |
| | psr-1 | Bifunctional arginine demethylase and lysyl-hydroxylase psr-1; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. (416 aa) |
| | jmjd-1.2 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (929 aa) |
| | cyp-37B1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (509 aa) |
| | rtel-1 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Belongs to the helicase family. RAD3/XPD subfamily. (994 aa) |
| | F25B5.5 | CDK5RAP1-like protein; Potential regulator of CDK5 activity; Belongs to the methylthiotransferase family. MiaB subfamily. (547 aa) |
| | egl-9 | Hypoxia-inducible factor prolyl hydroxylase; Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation. In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity. By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli. Mediates susceptibilit [...] (723 aa) |
| | glb-14 | GLOBIN domain-containing protein; Belongs to the globin family. (236 aa) |
| | glb-13 | GLOBIN domain-containing protein; Belongs to the globin family. (282 aa) |
| | jmjd-3.1 | Lysine-specific demethylase jmjd-3.1; Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell- autonomously in Y-to-PDA tra [...] (1061 aa) |
| | F15E6.6 | Uncharacterized protein. (1256 aa) |
| | cyp-35D1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-13A12 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (518 aa) |
| | cyp-13A11 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (517 aa) |
| | nubp-1 | Cytosolic Fe-S cluster assembly factor NUBP1 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Regulates cilium formation and structure ; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (313 aa) |
| | F10D7.3 | Uncharacterized monothiol glutaredoxin F10D7.3; Belongs to the glutaredoxin family. Monothiol subfamily. (146 aa) |
| | F10C2.4 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). (1081 aa) |
| | nmad-1 | DNA N6-methyl adenine demethylase; Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance. Plays an essential role in DNA replication and repair in the germline during meiosis. Binds to components of the DNA replication machinery such as top-2, and directs their localization to DNA to control DNA replication. (291 aa) |
| | hpx-2 | Heme peroxidase 2 heavy chain; Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx. It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans. (718 aa) |
| | cyp-14A5 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (492 aa) |
| | cyp-13B1 | Putative cytochrome P450 cyp-13B1; Cytochromes P450 are a group of heme-thiolate monooxygenases (Probable). They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (Probable). May play a role in the regulation of lifespan. (510 aa) |
| | cyp-37A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (508 aa) |
| | cyc-2.1 | Cytochrome c 2.1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (111 aa) |
| | cyp-43A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (526 aa) |
| | gbh-1 | Probable gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine. (421 aa) |
| | ftn-2 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (170 aa) |
| | cyc-1 | Cytochrome c domain-containing protein. (285 aa) |
| | ftn-1 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (170 aa) |
| | gcy-37 | Soluble guanylate cyclase gcy-37; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (708 aa) |
| | glb-12 | GLOBIN domain-containing protein; Belongs to the globin family. (266 aa) |
| | cyp-33C9 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (496 aa) |
| | cyp-35A4 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-33E1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | gcy-36 | Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...] (675 aa) |
| | cyp-33C1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | cyp-33C2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | cyp-25A4 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (501 aa) |
| | cyp-25A3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (502 aa) |
| | cyp-25A2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (502 aa) |
| | cyp-25A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (502 aa) |
| | cyp-36A1 | Probable cytochrome P450 CYP36A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (493 aa) |
| | C31H2.4 | Putative protein C31H2.4. (364 aa) |
| | cytb-5.1 | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (134 aa) |
| | glb-10 | GLOBIN domain-containing protein; Belongs to the globin family. (198 aa) |
| | tdo-2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. (403 aa) |
| | glb-9 | Globin-like protein 9. (279 aa) |
| | cyp-32A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (529 aa) |
| | glb-8 | GLOBIN domain-containing protein; Belongs to the globin family. (402 aa) |
| | dpyd-1 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil. (1059 aa) |
| | cyp-33B1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (496 aa) |
| | fath-1 | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (316 aa) |
| | glb-7 | GLOBIN domain-containing protein; Belongs to the globin family. (278 aa) |
| | glb-6 | Globin-like protein 6; May play a role as physiological sensor for oxygen via redox signaling and/or electron transport. (389 aa) |
| | glb-5 | GLOBIN domain-containing protein; Belongs to the globin family. (397 aa) |
| | dohh-1 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. (298 aa) |
| | daf-36 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. (428 aa) |
| | cyp-33A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (492 aa) |
| | nuo-1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (479 aa) |
| | gcy-32 | Soluble guanylate cyclase gcy-32; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases. (684 aa) |
| | cyp-35C1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa) |
| | let-721 | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family. (597 aa) |
| | cyp-35A2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-35A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | rnr-2 | Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (381 aa) |
| | tax-6 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa) |
| | agmo-1 | Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids; Belongs to the sterol desaturase family. TMEM195 subfamily. (505 aa) |
| | cat-2 | Tyrosine 3-monooxygenase; Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior. (524 aa) |
| | cyp-29A4 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (502 aa) |
| | cyp-23A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (534 aa) |
| | gad-3 | Probable aldehyde oxidase gad-3; May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1. Belongs to the xanthine dehydrogenase family. (1257 aa) |
| | cyp-34A10 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-34A9 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (516 aa) |
| | cyp-34A8 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-34A7 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-34A6 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (498 aa) |
| | cyp-34A5 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
