STRINGSTRING
wars-1 wars-1 glp-4 glp-4 ears-1 ears-1 vars-1 vars-1 ttll-4 ttll-4 lars-2 lars-2 aars-2 aars-2 rars-1 rars-1 ttll-9 ttll-9 F25B5.6 F25B5.6 sucl-2 sucl-2 nars-1 nars-1 fars-3 fars-3 rtcb-1 rtcb-1 rfl-1 rfl-1 pfas-1 pfas-1 dars-2 dars-2 F02A9.10 F02A9.10 E01A2.5 E01A2.5 pyr-1 pyr-1 pyc-1 pyc-1 ttll-5 ttll-5 skr-8 skr-8 skr-13 skr-13 skr-9 skr-9 skr-12 skr-12 sucg-1 sucg-1 uba-1 uba-1 sars-1 sars-1 tars-1 tars-1 skr-16 skr-16 C39B5.6 C39B5.6 adss-1 adss-1 acs-19 acs-19 prx-10 prx-10 rars-2 rars-2 lig-1 lig-1 iars-2 iars-2 qns-1 qns-1 aos-1 aos-1 lig-4 lig-4 skr-17 skr-17 sucl-1 sucl-1 dars-1 dars-1 ubc-17 ubc-17 pacs-1 pacs-1 ctps-1 ctps-1 pod-2 pod-2 skr-10 skr-10 gln-3 gln-3 yars-1 yars-1 Y105E8A.20 Y105E8A.20 Y106G6E.4 Y106G6E.4 skr-6 skr-6 Y41D4A.6 Y41D4A.6 qars-1 qars-1 mib-1 mib-1 skr-7 skr-7 skr-14 skr-14 ubc-16 ubc-16 nprt-1 nprt-1 ubc-13 ubc-13 fars-2 fars-2 skr-4 skr-4 nars-2 nars-2 Y66D12A.7 Y66D12A.7 Y73B6BL.14 Y73B6BL.14 gars-1 gars-1 hars-1 hars-1 pars-1 pars-1 pars-2 pars-2 T28F3.5 T28F3.5 aars-1 aars-1 sars-2 sars-2 fars-1 fars-1 ears-2 ears-2 kars-1 kars-1 lars-1 lars-1 skr-20 skr-20 iars-1 iars-1 gss-1 gss-1 gmps-1 gmps-1 yars-2 yars-2 ttll-15 ttll-15 gln-2 gln-2 sur-5 sur-5 ttll-11 ttll-11 mars-1 mars-1 skr-15 skr-15 skr-5 skr-5 suca-1 suca-1 skr-2 skr-2 skr-3 skr-3 F38B6.4 F38B6.4 gcs-1 gcs-1 mccc-1 mccc-1 pcca-1 pcca-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wars-1Tryptophanyl(W) Amino-acyl tRNA Synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (417 aa)
glp-4Valine--tRNA ligase. (1050 aa)
ears-1Glutamyl(E) Amino-acyl tRNA Synthetase. (1149 aa)
vars-1Valyl Amino-acyl tRNA Synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (978 aa)
ttll-4Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating. (601 aa)
lars-2Anticodon_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (859 aa)
aars-2Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
rars-1Probable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (713 aa)
ttll-9Probable tubulin polyglutamylase ttll-9; Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth. (417 aa)
F25B5.6Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (521 aa)
sucl-2Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (321 aa)
nars-1Asparagine--tRNA ligase, cytoplasmic; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Belongs to the class-II aminoacyl-tRNA synthetase family. (545 aa)
fars-3Phenylalanine--tRNA ligase beta subunit. (591 aa)
rtcb-1RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs. Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress- induced unfolded protein response. Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1. Belongs to the RtcB family. (505 aa)
rfl-1NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric rfl-1 (uba-3)-ula-1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba-3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc-12 (By similarity). Required for cytokinesis and mitotic spindle orientation during early embryogenesis. (430 aa)
pfas-1Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family. (1324 aa)
dars-2AA_TRNA_LIGASE_II domain-containing protein. (593 aa)
F02A9.10Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family. (608 aa)
E01A2.5Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. (249 aa)
pyr-1Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP- sugars required for heparan sulfate proteoglycan biosynthesis. Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles ; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. (2198 aa)
pyc-1Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa)
ttll-5Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons. (730 aa)
skr-8SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-13SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-9SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-12SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
sucg-1Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (415 aa)
uba-1UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1113 aa)
sars-1Probable serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec) (By similarity). (487 aa)
tars-1Threonine--tRNA ligase, cytoplasmic; Belongs to the class-II aminoacyl-tRNA synthetase family. (725 aa)
skr-16SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa)
C39B5.6Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (506 aa)
adss-1Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (457 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
prx-10Tryptophan--tRNA ligase, mitochondrial; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
rars-2DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (512 aa)
lig-1DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (773 aa)
iars-2Isoleucyl Amino-acyl tRNA Synthetase. (970 aa)
qns-1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (703 aa)
aos-1SUMO-activating enzyme subunit aos-1; The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable). (350 aa)
lig-4LIGase. (741 aa)
skr-17SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa)
sucl-1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (322 aa)
dars-1Aspartate--tRNA ligase, cytoplasmic. (531 aa)
ubc-17Probable ubiquitin-conjugating enzyme protein 17; Belongs to the ubiquitin-conjugating enzyme family. (728 aa)
pacs-1Phosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. (423 aa)
ctps-1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (672 aa)
pod-2Uncharacterized protein. (2165 aa)
skr-10SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa)
gln-3Glutamine synthetase. (388 aa)
yars-1Tyrosine--tRNA ligase. (722 aa)
Y105E8A.20tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (524 aa)
Y106G6E.4Probable 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10- methenyltetrahydrofolate (By similarity). (206 aa)
skr-6SKp1 Related (Ubiquitin ligase complex component). (106 aa)
Y41D4A.6Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (454 aa)
qars-1Probable glutamine--tRNA ligase. (786 aa)
mib-1MIB (MIndBomb) ubiquitin ligase homolog. (765 aa)
skr-7SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-14SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa)
ubc-16Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Together with ubc-18, required for the ubiquitination of membranous organelles, and the removal of paternal mitochondria from early embryos. (152 aa)
nprt-1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. (562 aa)
ubc-13Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa)
fars-2Mitochondrial phenylalanyl-tRNA synthetase. (458 aa)
skr-4SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa)
nars-2AA_TRNA_LIGASE_II domain-containing protein. (418 aa)
Y66D12A.7Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (175 aa)
Y73B6BL.14DNA_ligase_A_N domain-containing protein. (93 aa)
gars-1Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family. (742 aa)
hars-1Histidine--tRNA ligase; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (Probable). Required for germ cell development. Belongs to the class-II aminoacyl-tRNA synthetase family. (524 aa)
pars-1Prolyl Amino-acyl tRNA Synthetase. (581 aa)
pars-2AA_TRNA_LIGASE_II domain-containing protein. (454 aa)
T28F3.5Uncharacterized protein. (1612 aa)
aars-1Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (793 aa)
sars-2AA_TRNA_LIGASE_II domain-containing protein. (441 aa)
fars-1AA_TRNA_LIGASE_II domain-containing protein. (552 aa)
ears-2tRNA-synt_1c domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (481 aa)
kars-1Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. (596 aa)
lars-1Leucine--tRNA ligase; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. (1186 aa)
skr-20SKp1 Related (Ubiquitin ligase complex component). (173 aa)
iars-1Isoleucine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (1141 aa)
gss-1Glutathione synthetase. (490 aa)
gmps-1Probable GMP synthase [glutamine-hydrolyzing]. (745 aa)
yars-2Tyrosine--tRNA ligase. (447 aa)
ttll-15Probable tubulin polyglutamylase ttll-15; Probable polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins. Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family. (513 aa)
gln-2Probable glutamine synthetase. (367 aa)
sur-5Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. Belongs to the ATP-dependent AMP-binding enzyme family. (700 aa)
ttll-11Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...] (707 aa)
mars-1Methionine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (917 aa)
skr-15SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa)
skr-5SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa)
suca-1Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (435 aa)
skr-2SKp1 Related (Ubiquitin ligase complex component). (174 aa)
skr-3SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa)
F38B6.4Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (975 aa)
gcs-1Glutamate--cysteine ligase; Plays a role in resistance to arsenite. May play a role in the oxidative stress response induced by reactive oxygen species produced during infection by pathogenic bacteria. Together with trxr-1, required for the reduction of disulfide groups in the cuticle during molting. (654 aa)
mccc-1MethylCrotonoyl-Coenzyme A Carboxylase (Alpha). (671 aa)
pcca-1Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] (724 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: medium (64%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.