STRINGSTRING
gpx-1 gpx-1 skpo-2 skpo-2 gpx-3 gpx-3 gpx-5 gpx-5 ctl-3 ctl-3 gpx-6 gpx-6 prdx-3 prdx-3 pxn-1 pxn-1 mlt-7 mlt-7 gpx-4 gpx-4 ctl-1 ctl-1 ctl-2 ctl-2 gpx-2 gpx-2 skpo-1 skpo-1 hpx-2 hpx-2 gpx-8 gpx-8 bli-3 bli-3 pxn-2 pxn-2 gpx-7 gpx-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
skpo-2ShK domain and PerOxidase domain containing protein. (729 aa)
gpx-3Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
gpx-5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
ctl-3Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa)
gpx-6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
prdx-3Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (226 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
mlt-7Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens. (724 aa)
gpx-4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (126 aa)
ctl-1Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa)
ctl-2Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. (500 aa)
gpx-2Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (179 aa)
skpo-1Peroxidase skpo-1; Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. Belongs to the peroxidase family. XPO subfamily. (655 aa)
hpx-2Heme peroxidase 2 heavy chain; Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx. It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans. (718 aa)
gpx-8Glutathione PeroXidase. (145 aa)
bli-3Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...] (1497 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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