STRINGSTRING
cth-2 cth-2 spl-2 spl-2 mel-32 mel-32 basl-1 basl-1 bas-1 bas-1 cbl-1 cbl-1 kynu-1 kynu-1 oatr-1 oatr-1 cysl-1 cysl-1 sptl-1 sptl-1 secs-1 secs-1 F09E5.8 F09E5.8 F13B12.4 F13B12.4 cth-1 cth-1 F26H9.5 F26H9.5 tatn-1 tatn-1 sptl-2 sptl-2 cysl-4 cysl-4 tdc-1 tdc-1 bcat-1 bcat-1 gta-1 gta-1 cysl-2 cysl-2 odc-1 odc-1 mocs-1 mocs-1 cysl-3 cysl-3 R102.4 R102.4 gldc-1 gldc-1 eppl-1 eppl-1 got-1.2 got-1.2 T09B4.8 T09B4.8 agxt-1 agxt-1 pygl-1 pygl-1 sptl-3 sptl-3 spl-3 spl-3 unc-25 unc-25 Y44A6D.5 Y44A6D.5 spl-1 spl-1 hdl-1 hdl-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cth-2Putative cystathionine gamma-lyase 2; Belongs to the trans-sulfuration enzymes family. (392 aa)
spl-2Sphingosine Phosphate Lyase. (542 aa)
mel-32Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa)
basl-1BAS-Like. (509 aa)
bas-1Biogenic Amine Synthesis related. (523 aa)
cbl-1Cystathionine Beta Lyase. (451 aa)
kynu-1Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (478 aa)
oatr-1Probable ornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
cysl-1Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. (341 aa)
sptl-1Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. (458 aa)
secs-1O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Belongs to the SepSecS family. (523 aa)
F09E5.8Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. (244 aa)
F13B12.4Putative pyridoxal-phosphate dependent protein F13B12.4; Belongs to the cysteine synthase/cystathionine beta- synthase family. Highly divergent. (435 aa)
cth-1CystaTHionine gamma lyase. (392 aa)
F26H9.5Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (370 aa)
tatn-1Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (464 aa)
sptl-2Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (586 aa)
cysl-4Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa)
tdc-1Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family. (705 aa)
bcat-1Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (415 aa)
gta-1Probable 4-aminobutyrate aminotransferase, mitochondrial. (483 aa)
cysl-2Bifunctional L-3-cyanoalanine synthase/cysteine synthase; Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O- acetylserine and hydrogen sulfide. By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection. Involved in fertility, growth and aging. Does not mediate surv [...] (337 aa)
odc-1Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (422 aa)
mocs-1Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (709 aa)
cysl-3Cysteine synthase 3; Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide. Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa)
R102.4Uncharacterized protein R102.4; Belongs to the threonine aldolase family. (413 aa)
gldc-1Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (979 aa)
eppl-1Ethanolamine-phosphate phospho-lyase homolog 1. (467 aa)
got-1.2Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. (408 aa)
T09B4.8Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
agxt-1Serine--pyruvate aminotransferase. (405 aa)
pygl-1Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (882 aa)
sptl-3Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (521 aa)
spl-3Sphingosine Phosphate Lyase. (606 aa)
unc-25Glutamic acid decarboxylase. (508 aa)
Y44A6D.5Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
spl-1Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Essential for normal development, intestinal integrity, growth and reproduction. (552 aa)
hdl-1Probable aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (905 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.