Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C16C10.4 | hda-1 | C16C10.4.1 | C53A5.3.1 | Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.492 |
| C16C10.4 | hda-2 | C16C10.4.1 | C08B11.2.1 | Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] | 0.494 |
| C16C10.4 | lin-53 | C16C10.4.1 | K07A1.12.1 | Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. | Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...] | 0.647 |
| C16C10.4 | rba-1 | C16C10.4.1 | K07A1.11.1 | Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.497 |
| C16C10.4 | sin-3 | C16C10.4.1 | F02E9.4b.1 | Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. | Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). | 0.696 |
| ces-2 | ztf-11 | ZK909.4.1 | F52F12.6a.1 | Cell death specification protein 2; Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'; Belongs to the bZIP family. | Zinc finger protein ztf-11; Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis. Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis. Required for the generation of postembryonic neurons from epidermal cells. Belongs to the MYT1 family. | 0.401 |
| ctbp-1 | gei-8 | F49E10.5a.1 | C14B9.6a.3 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | 0.772 |
| ctbp-1 | hda-1 | F49E10.5a.1 | C53A5.3.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.892 |
| ctbp-1 | hda-2 | F49E10.5a.1 | C08B11.2.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] | 0.892 |
| ctbp-1 | impt-1 | F49E10.5a.1 | Y52B11A.2a.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family. | 0.823 |
| ctbp-1 | lsd-1 | F49E10.5a.1 | T08D10.2.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. | 0.707 |
| ctbp-1 | spr-1 | F49E10.5a.1 | D1014.8.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. | 0.813 |
| ctbp-1 | spr-5 | F49E10.5a.1 | Y40B1B.6.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.640 |
| ctbp-1 | zag-1 | F49E10.5a.1 | F28F9.1.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Zinc finger E-box-binding homeobox protein zag-1; Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron- specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Required for axon guidance. Involved in the proper development of the pharynx. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. | 0.768 |
| daf-16 | egl-27 | R13H8.1h.1 | C04A2.3a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Egg-laying defective protein 27; Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. | 0.554 |
| daf-16 | fos-1 | R13H8.1h.1 | F29G9.4b.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.437 |
| daf-16 | gei-8 | R13H8.1h.1 | C14B9.6a.3 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | 0.506 |
| daf-16 | hda-4 | R13H8.1h.1 | C10E2.3a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development. | 0.429 |
| daf-16 | hif-1 | R13H8.1h.1 | F38A6.3b.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Hypoxia-inducible factor 1; A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureu [...] | 0.932 |
| daf-16 | pha-4 | R13H8.1h.1 | F38A6.1a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] | 0.562 |
page 1 of 19