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exc-4 exc-4 unc-103 unc-103 C32C4.1 C32C4.1 clhm-1 clhm-1 egl-19 egl-19 unc-36 unc-36 kvs-1 kvs-1 cca-1 cca-1 exp-2 exp-2 shw-1 shw-1 egl-2 egl-2 exl-1 exl-1 kvs-3 kvs-3 irk-3 irk-3 irk-2 irk-2 kqt-2 kqt-2 irk-1 irk-1 egl-36 egl-36 shw-3 shw-3 unc-2 unc-2 kvs-4 kvs-4 slo-1 slo-1 kvs-5 kvs-5 shl-1 shl-1 shk-1 shk-1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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exc-4Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa)
unc-103Potassium voltage-gated channel unc-103; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior ; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (898 aa)
C32C4.1BTB domain-containing protein; Belongs to the potassium channel family. (575 aa)
clhm-1Calcium homeostasis modulator protein; Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion; Belongs to the CALHM family. (329 aa)
egl-19Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1877 aa)
unc-36Voltage-dependent calcium channel unc-36; May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization- induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of [...] (1249 aa)
kvs-1Uncharacterized protein; Belongs to the potassium channel family. (495 aa)
cca-1Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1885 aa)
exp-2Uncharacterized protein; Belongs to the potassium channel family. (510 aa)
shw-1BTB domain-containing protein; Belongs to the potassium channel family. (619 aa)
egl-2Uncharacterized protein. (959 aa)
exl-1Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family. (238 aa)
kvs-3Uncharacterized protein; Belongs to the potassium channel family. (451 aa)
irk-3IRK_C domain-containing protein. (384 aa)
irk-2Inward Rectifying K (Potassium) channel family. (497 aa)
kqt-2Ion_trans domain-containing protein; Belongs to the potassium channel family. (695 aa)
irk-1Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa)
egl-36Potassium voltage-gated channel protein egl-36; Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily. (558 aa)
shw-3BTB domain-containing protein; Belongs to the potassium channel family. (500 aa)
unc-2EF-hand domain-containing protein. (2171 aa)
kvs-4Probable voltage-gated potassium channel subunit kvs-4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (512 aa)
slo-1Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa)
kvs-5Ion_trans domain-containing protein; Belongs to the potassium channel family. (600 aa)
shl-1BTB domain-containing protein; Belongs to the potassium channel family. (578 aa)
shk-1Potassium voltage-gated channel protein shk-1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d. (536 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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