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| | cdc-25.1 | M-phase inducer phosphatase cdc-25.1. (604 aa) |
| | K07F5.8 | Tyrosine-protein phosphatase. (284 aa) |
| | K09F6.3 | Protein-tyrosine-phosphatase. (1391 aa) |
| | tns-1 | Tensin homolog; Probable phosphatase which regulates axon regeneration after injury by linking the svh-2 and integrin signaling pathways. (1354 aa) |
| | M04G7.2 | Tyrosine-protein phosphatase. (550 aa) |
| | R06B10.2 | Protein-tyrosine-phosphatase. (1014 aa) |
| | rpap-2 | Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2; Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. Belongs to the RPAP2 family. (455 aa) |
| | R155.3 | Protein-tyrosine-phosphatase. (1165 aa) |
| | gsp-4 | Serine/threonine-protein phosphatase PP1-delta; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium. (305 aa) |
| | daf-18 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] (962 aa) |
| | ssup-72 | RNA polymerase II subunit A C-terminal domain phosphatase ssup-72; Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1. By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre- mRNAs, including unc-44 and dlk-1 mRNAs. This results in the tissue-specific expression of unc-44 isoforms. (197 aa) |
| | T13H5.1 | Tyrosine-protein phosphatase. (864 aa) |
| | fem-2 | Protein phosphatase fem-2; Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin- dependent protein kinase unc-43/CAMKII in vitro. Involved in the regulation of sex determination. Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes. Promotes apoptosis. Belongs to the PP2C family. (449 aa) |
| | T20B6.1 | Protein-tyrosine-phosphatase. (302 aa) |
| | T22C1.8 | Tyrosine-protein phosphatase. (591 aa) |
| | ppm-2 | Probable protein phosphatase 2C T23F11.1. (356 aa) |
| | T27A3.5 | Tyrosine-protein phosphatase. (355 aa) |
| | pdp-1 | PPM-type phosphatase domain-containing protein. (451 aa) |
| | T28F4.3 | Protein-tyrosine-phosphatase. (490 aa) |
| | W03F11.4 | Protein-tyrosine-phosphatase. (1371 aa) |
| | gsp-3 | Serine/threonine-protein phosphatase PP1-gamma; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium. (305 aa) |
| | W09D10.4 | Protein phosphatase; Belongs to the PP2C family. (330 aa) |
| | Y113G7C.1 | Protein-tyrosine-phosphatase. (1494 aa) |
| | pph-5 | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase. Dephosphorylates cdc-37. Probably by dephosphorylating separase sep-1, may be involved in sep-1-mediated exocytosis of cortical granules during meiotic anaphase and mitotic cytokinesis. (496 aa) |
| | Y41D4A.5 | Tyrosine-protein phosphatase. (469 aa) |
| | scpl-3 | CTD small phosphatase-like protein 3; Probable phosphatase; Belongs to the CTDSPL2 family. (287 aa) |
| | Y48G9A.9 | Tyrosine-protein phosphatase. (361 aa) |
| | pph-4.2 | Serine/threonine-protein phosphatase 4 catalytic subunit 2; Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis. (321 aa) |
| | ppm-1.D | PPM-type phosphatase domain-containing protein. (766 aa) |
| | Y71G12B.31 | Tyrosine-protein phosphatase. (423 aa) |
| | pph-4.1 | Serine/threonine-protein phosphatase 4 catalytic subunit 1; Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis. During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulti [...] (333 aa) |
| | ZK354.8 | Tyrosine-protein phosphatase. (483 aa) |
| | ZK484.7 | Tyrosine-protein phosphatase. (344 aa) |
| | cdc-25.3 | M-phase inducer phosphatase cdc-25.3. (316 aa) |
| | ZK616.65 | Tyrosine-protein phosphatase. (543 aa) |
| | B0207.1 | Tyrosine-protein phosphatase. (564 aa) |
| | B0280.11 | Putative tyrosine-protein phosphatase B0280.11. (441 aa) |
| | scpl-1 | CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa) |
| | C02B10.6 | Tyrosine-protein phosphatase. (398 aa) |
| | tax-6 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa) |
| | pph-1 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (349 aa) |
| | lip-1 | Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | C06A1.3 | Putative serine/threonine-protein phosphatase C06A1.3. (364 aa) |
| | ptp-3 | Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors. (2248 aa) |
| | C09H5.7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa) |
| | C15H7.3 | Putative tyrosine-protein phosphatase C15H7.3. (398 aa) |
| | cdc-14 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] (709 aa) |
| | C17H12.3 | Tyrosine-protein phosphatase. (374 aa) |
| | C23G10.1 | Putative serine/threonine-protein phosphatase C23G10.1. (456 aa) |
| | C27B7.6 | Putative serine/threonine-protein phosphatase C27B7.6. (454 aa) |
| | C33H5.16 | Tyrosine-protein phosphatase. (341 aa) |
| | pph-6 | Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6) (By similarity). In complex with saps-1, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non- muscle myosin II nmy-2 and thus contributing to correct spindle positioning. Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5. Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily. (331 aa) |
| | ppm-1.H | PPM-type phosphatase domain-containing protein. (540 aa) |
| | ptp-1 | Tyrosine-protein phosphatase 1. (1026 aa) |
| | eya-1 | Eyes absent homolog 1; Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister ce [...] (503 aa) |
| | C55B7.3 | Tyrosine-protein phosphatase. (346 aa) |
| | vhp-1 | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa) |
| | F10G8.1 | Tyrosine-protein phosphatase. (346 aa) |
| | eak-6 | Tyrosine-protein phosphatase non-receptor type eak-6; Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1. (405 aa) |
| | cdc-25.2 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. (480 aa) |
| | F20H11.4 | Protein-tyrosine-phosphatase. (446 aa) |
| | ppm-1.A | Protein phosphatase ppm-1.A; Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3. Belongs to the PP2C family. (468 aa) |
| | F25H5.7 | Protein-tyrosine-phosphatase. (490 aa) |
| | gsp-1 | Serine/threonine-protein phosphatase PP1-alpha; Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Dephosphorylates translation initiation factor eIF2alpha. Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Belongs to the PPP phosphatase family. PP-1 subfamily. (329 aa) |
| | ilkp-1 | PPM-type phosphatase domain-containing protein. (322 aa) |
| | fcp-1 | RNA polymerase II subunit A C-terminal domain phosphatase; During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1. Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage. May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells. (659 aa) |
| | F36H1.3 | Tyrosine-protein phosphatase. (532 aa) |
| | F36H12.10 | Tyrosine-protein phosphatase. (398 aa) |
| | let-92 | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] (318 aa) |
| | ppm-1.G | Protein phosphatase ppm-1.G; Belongs to the PP2C family. (491 aa) |
| | phlp-2 | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. (1126 aa) |
| | dep-1 | Receptor-type tyrosine-protein phosphatase dep-1; Phosphatase which may dephosphorylate receptor let-23 and thereby regulate cell fate during the development of the vulva and the excretory system. By inhibiting let-23 signaling prevents the establishment of a primary cell fate in the descendants of vulva precursor cells P5.p and P7.p. Similarly, may prevent duct cell fate in ABpr precursor. Also dephosphorylates the beta-integrin subunit pat-3, probably within the alpha pat-2/beta pat-3 integrin receptor complex, which leads to down- stream effects including the negative regulation of [...] (1367 aa) |
| | cnep-1 | CTD nuclear envelope phosphatase 1 homolog; Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. (276 aa) |
| | F47B3.1 | Tyrosine-protein phosphatase. (363 aa) |
| | F47B3.2 | Uncharacterized protein. (130 aa) |
| | F47B3.7 | Tyrosine-protein phosphatase. (374 aa) |
| | F54C8.4 | Probable tyrosine-protein phosphatase F54C8.4. (359 aa) |
| | F54F12.1 | Protein-tyrosine-phosphatase. (1217 aa) |
| | F55F8.7 | Protein-tyrosine-phosphatase. (491 aa) |
| | gsp-2 | Serine/threonine-protein phosphatase PP1-beta; Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA- mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic matu [...] (333 aa) |
| | clr-1 | Receptor-type tyrosine-protein phosphatase; Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of [...] (1444 aa) |
| | ptp-2 | Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...] (668 aa) |
| | H06I04.5 | Protein-tyrosine-phosphatase. (1138 aa) |
| | ptp-4 | Tyrosine-protein phosphatase 4. (1159 aa) |
