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delm-2 delm-2 nhx-9 nhx-9 asic-1 asic-1 eat-4 eat-4 egas-3 egas-3 egas-2 egas-2 egas-1 egas-1 Y57G11C.44 Y57G11C.44 snf-5 snf-5 nhx-8 nhx-8 mec-6 mec-6 asic-2 asic-2 acd-5 acd-5 del-10 del-10 del-4 del-4 dat-1 dat-1 glt-4 glt-4 del-6 del-6 vglu-3 vglu-3 mec-4 mec-4 unc-8 unc-8 nac-2 nac-2 pbo-4 pbo-4 nac-3 nac-3 del-5 del-5 degt-1 degt-1 del-3 del-3 acd-4 acd-4 nac-1 nac-1 nkb-3 nkb-3 egas-4 egas-4 nhx-5 nhx-5 nhx-6 nhx-6 F58G6.8 F58G6.8 nhx-1 nhx-1 nhx-2 nhx-2 slc-17.3 slc-17.3 ncx-7 ncx-7 ncx-6 ncx-6 del-8 del-8 ncx-9 ncx-9 nkb-1 nkb-1 del-9 del-9 acd-1 acd-1 acd-2 acd-2 acd-3 acd-3 slc-17.2 slc-17.2 unc-105 unc-105 del-7 del-7 deg-1 deg-1 cho-1 cho-1 nhx-3 nhx-3 del-1 del-1 flr-1 flr-1 F13H10.3 F13H10.3 nhx-4 nhx-4 mec-10 mec-10 delm-1 delm-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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delm-2DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (608 aa)
nhx-9Probable Na(+)/H(+) antiporter nhx-9; Serves some physiological function other than regulation of cellular pH. (667 aa)
asic-1Degenerin-like protein asic-1; Proton-gated cation channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions (By similarity). (823 aa)
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
egas-3EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (921 aa)
egas-2EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (919 aa)
egas-1EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (938 aa)
Y57G11C.44Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (155 aa)
snf-5Sodium-dependent transporter snf-5; Sodium-dependent amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-proline and L-methionine, and also of acidic amino acids such as L-glutamic acid and L-aspartic acid (Probable). May additionally have a role in potassium-dependent amino acid absorption. In response to the availability of amino acid nutrients, may play a role in dauer formation. May play a role in promoting fertility. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (728 aa)
nhx-8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (681 aa)
mec-6Mechanosensory abnormality protein 6; Probable touch-cell sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Interacts with degenerin channel proteins and stabilizes the channel. Non-voltage- gated amiloride-sensitive cation channel permeable for sodium, potassium, lithium and N-methylglucamine. Belongs to the paraoxonase family. (377 aa)
asic-2Degenerin-like protein asic-2. (545 aa)
acd-5Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (714 aa)
del-10Degenerin-like protein del-10. (1069 aa)
del-4DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (527 aa)
dat-1Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. (615 aa)
glt-4Putative sodium-dependent excitatory amino acid transporter glt-4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D- aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. (499 aa)
del-6DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (577 aa)
vglu-3Potential vesicular glutamate transporter vglu-3. (544 aa)
mec-4Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (768 aa)
unc-8Degenerin unc-8. (778 aa)
nac-2Sodium-dependent high-affinity dicarboxylate transporter 2; High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. (585 aa)
pbo-4Na(+)/H(+) exchanger protein 7; Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. (783 aa)
nac-3Sodium-dependent high-affinity dicarboxylate transporter 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Plays a role in the regulation of life span. (566 aa)
del-5DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
degt-1DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (852 aa)
del-3DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (487 aa)
acd-4Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (613 aa)
nac-1Sodium-dependent low-affinity dicarboxylate transporter 1; Low affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. (582 aa)
nkb-3Probable sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size. (317 aa)
egas-4EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (883 aa)
nhx-5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (630 aa)
nhx-6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (634 aa)
F58G6.8Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (198 aa)
nhx-1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (514 aa)
nhx-2Na(+)/H(+) exchanger protein 2; Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept- 1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway. (644 aa)
slc-17.3Uncharacterized transporter slc-17.3. (535 aa)
ncx-7Putative sodium/calcium exchanger 7. (672 aa)
ncx-6Putative sodium/calcium exchanger 6. (590 aa)
del-8DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (553 aa)
ncx-9Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC- dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (701 aa)
nkb-1Sodium/potassium-transporting ATPase subunit beta-1; Non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). May also may function in the peptidic vesicle transport pathway from the endoplasmic reticulum for the defecation behaviors. (320 aa)
del-9DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (579 aa)
acd-1Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (635 aa)
acd-2Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (693 aa)
acd-3Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (484 aa)
slc-17.2Uncharacterized transporter slc-17.2. (493 aa)
unc-105Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (962 aa)
del-7DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (614 aa)
deg-1Degenerin deg-1; Probable sodium channel subunit. Required by a subset of neurons. (778 aa)
cho-1High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. (576 aa)
nhx-3Probable Na(+)/H(+) antiporter nhx-3; Plays a role in epithelial membrane transport processes. (670 aa)
del-1Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (694 aa)
flr-1FLR-1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (638 aa)
F13H10.3Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. (617 aa)
nhx-4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (749 aa)
mec-10Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (724 aa)
delm-1DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (626 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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