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gsnl-1 gsnl-1 cyc-2.1 cyc-2.1 ifb-1 ifb-1 ifb-2 ifb-2 F10C1.8 F10C1.8 hil-3 hil-3 ifd-2 ifd-2 clsp-1 clsp-1 imb-1 imb-1 F35A5.8 F35A5.8 ifc-1 ifc-1 ifa-1 ifa-1 ptl-1 ptl-1 hmg-1.2 hmg-1.2 ftt-2 ftt-2 ifa-3 ifa-3 cnb-1 cnb-1 hil-6 hil-6 apr-1 apr-1 ifa-4 ifa-4 lmn-1 lmn-1 spc-1 spc-1 K11D12.9 K11D12.9 dapk-1 dapk-1 par-5 par-5 M117.3 M117.3 his-24 his-24 ifc-2 ifc-2 fnta-1 fnta-1 ifd-1 ifd-1 ced-9 ced-9 gck-1 gck-1 unc-40 unc-40 dlc-1 dlc-1 mua-6 mua-6 zoo-1 zoo-1 dlc-3 dlc-3 dlc-4 dlc-4 Y54G2A.18 Y54G2A.18 dlc-5 dlc-5 hil-2 hil-2 cyc-2.2 cyc-2.2 ZC373.5 ZC373.5 hil-5 hil-5 C03B1.5 C03B1.5 C07A9.5 C07A9.5 hil-4 hil-4 C27B7.7 C27B7.7 hil-1 hil-1 ifp-1 ifp-1 acin-1 acin-1 ced-3 ced-3 C50C3.2 C50C3.2 eat-3 eat-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. (475 aa)
cyc-2.1Cytochrome c 2.1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (111 aa)
ifb-1Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. (589 aa)
ifb-2Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa)
F10C1.8LTD domain-containing protein. (160 aa)
hil-3Histone H1.3; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (208 aa)
ifd-2Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (443 aa)
clsp-1CLaSPin homolog. (752 aa)
imb-1Importin N-terminal domain-containing protein. (896 aa)
F35A5.8BAR domain-containing protein. (366 aa)
ifc-1Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (500 aa)
ifa-1Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis. (592 aa)
ptl-1Microtubule-associated protein. (458 aa)
hmg-1.2High mobility group protein 1.2. (235 aa)
ftt-214-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. (248 aa)
ifa-3Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures. (581 aa)
cnb-1Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] (171 aa)
hil-6Putative histone H1.6; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (190 aa)
apr-1Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...] (1188 aa)
ifa-4Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa)
lmn-1Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa)
spc-1SPeCtrin. (2432 aa)
K11D12.9RING-type domain-containing protein. (400 aa)
dapk-1Death-associated protein kinase dapk-1; Negative regulator of epidermal barrier repair and innate immune responses to wounding. The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1. In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA. Appears to act downs [...] (1425 aa)
par-514-3-3-like protein 1. (248 aa)
M117.314_3_3 domain-containing protein. (125 aa)
his-24Histone 24; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (208 aa)
ifc-2Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion. (1248 aa)
fnta-1FarNesylTransferase, Alpha subunit. (328 aa)
ifd-1Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (575 aa)
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa)
gck-1Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (803 aa)
unc-40Unc-40 protein. (1415 aa)
dlc-1Dynein light chain 1, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (By similarity). Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf- 2 in the germline. P [...] (89 aa)
mua-6Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos. (581 aa)
zoo-1ZO-1 (Zonula Occludens tight junctional protein) Ortholog. (1172 aa)
dlc-3Dynein light chain. (129 aa)
dlc-4Dynein light chain. (129 aa)
Y54G2A.184D656. (213 aa)
dlc-5Dynein Light Chain. (186 aa)
hil-2Histone H1.2; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (191 aa)
cyc-2.2Probable cytochrome c 2.2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (123 aa)
ZC373.5Probable methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (263 aa)
hil-5Histone H1.5; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (225 aa)
C03B1.5Putative tyrosine-protein kinase C03B1.5. (328 aa)
C07A9.5Uncharacterized calcium-binding protein C07A9.5. (358 aa)
hil-4Histone H1.4; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (253 aa)
C27B7.7Ig-like and fibronectin type-III domain-containing protein C27B7.7. (1456 aa)
hil-1Histone H1.X. (232 aa)
ifp-1Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (776 aa)
acin-1ACINus (Mammalian Apoptotic Chromatin condensation Inducer in the Nucleus) homolog. (580 aa)
ced-3Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa)
C50C3.2Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa)
eat-3Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (964 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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