STRINGSTRING
acy-1 acy-1 ckk-1 ckk-1 acy-3 acy-3 pde-3 pde-3 sel-2 sel-2 acy-2 acy-2 F47F2.1 F47F2.1 kin-2 kin-2 acy-4 acy-4 pde-1 pde-1 zyg-8 zyg-8 Y94H6A.12 Y94H6A.12 Y94H6A.7 Y94H6A.7 kin-1 kin-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acy-1Adenylyl CYclase. (1253 aa)
ckk-1Calcium/calmodulin-dependent protein kinase kinase; Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1. Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation. (541 aa)
acy-3Adenylyl CYclase. (1243 aa)
pde-3Probable 3',5'-cyclic phosphodiesterase pde-3. (693 aa)
sel-2Putative neurobeachin homolog; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells. (2507 aa)
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
F47F2.1cAMP-dependent protein kinase, catalytic subunit-like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily. (398 aa)
kin-2cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. (376 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
pde-1Probable 3',5'-cyclic phosphodiesterase pde-1; Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels. (664 aa)
zyg-8Serine/threonine-protein kinase zyg-8; Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase. (802 aa)
Y94H6A.12Uncharacterized protein. (120 aa)
Y94H6A.7LMWPc domain-containing protein. (164 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.