STRINGSTRING
lip-1 lip-1 C16A3.2 C16A3.2 C24F3.2 C24F3.2 E02D9.1 E02D9.1 vhp-1 vhp-1 F13D11.3 F13D11.3 mek-2 mek-2 Y54F10BM.13 Y54F10BM.13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lip-1Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
C16A3.2Uncharacterized protein. (221 aa)
C24F3.2Uncharacterized protein. (272 aa)
E02D9.1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
vhp-1Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa)
F13D11.3Uncharacterized protein. (174 aa)
mek-2Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. (387 aa)
Y54F10BM.13Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (227 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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