STRINGSTRING
shw-3 shw-3 twk-21 twk-21 twk-22 twk-22 unc-58 unc-58 twk-2 twk-2 twk-40 twk-40 twk-42 twk-42 twk-33 twk-33 egl-23 egl-23 Y39A1A.20 Y39A1A.20 Y39A1A.21 Y39A1A.21 twk-46 twk-46 gbb-1 gbb-1 twk-31 twk-31 kvs-4 kvs-4 kqt-3 kqt-3 kvs-5 kvs-5 twk-45 twk-45 twk-44 twk-44 shl-1 shl-1 twk-8 twk-8 twk-4 twk-4 twk-9 twk-9 shk-1 shk-1 gbb-2 gbb-2 gpb-1 gpb-1 shw-1 shw-1 egl-2 egl-2 twk-6 twk-6 twk-23 twk-23 twk-11 twk-11 twk-1 twk-1 twk-7 twk-7 twk-12 twk-12 twk-35 twk-35 twk-43 twk-43 twk-47 twk-47 F35A5.4 F35A5.4 twk-30 twk-30 kvs-3 kvs-3 twk-29 twk-29 gpb-2 gpb-2 twk-16 twk-16 twk-32 twk-32 twk-36 twk-36 egl-36 egl-36 twk-49 twk-49 twk-13 twk-13 irk-1 irk-1 kqt-2 kqt-2 twk-3 twk-3 twk-25 twk-25 irk-2 irk-2 twk-48 twk-48 twk-34 twk-34 twk-10 twk-10 gpc-1 gpc-1 K01H12.4 K01H12.4 kcnl-3 kcnl-3 B0310.1 B0310.1 twk-24 twk-24 twk-5 twk-5 kcnl-1 kcnl-1 C32C4.1 C32C4.1 twk-26 twk-26 twk-37 twk-37 twk-28 twk-28 kcnl-4 kcnl-4 kvs-1 kvs-1 kcnl-2 kcnl-2 gpc-2 gpc-2 exp-2 exp-2 unc-103 unc-103 C27F2.6 C27F2.6 kqt-1 kqt-1 twk-39 twk-39 twk-18 twk-18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
shw-3BTB domain-containing protein; Belongs to the potassium channel family. (500 aa)
twk-21TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (581 aa)
twk-22TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (757 aa)
unc-58Uncoordinated protein 58; Has a role in mobility, possibly in the transport of potassium in muscles; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (591 aa)
twk-2TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (1519 aa)
twk-40TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (436 aa)
twk-42TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (444 aa)
twk-33TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (617 aa)
egl-23Uncharacterized protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (726 aa)
Y39A1A.20Uncharacterized protein. (113 aa)
Y39A1A.21ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. (190 aa)
twk-46Two pore potassium channel protein sup-9. (319 aa)
gbb-1Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (899 aa)
twk-31TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (1136 aa)
kvs-4Probable voltage-gated potassium channel subunit kvs-4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (512 aa)
kqt-3Potassium channel, KvQLT family; Belongs to the potassium channel family. (621 aa)
kvs-5Ion_trans domain-containing protein; Belongs to the potassium channel family. (600 aa)
twk-45TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (508 aa)
twk-44TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (733 aa)
shl-1BTB domain-containing protein; Belongs to the potassium channel family. (578 aa)
twk-8TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (769 aa)
twk-4TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (418 aa)
twk-9TWiK family of potassium channels protein 9; Potassium channel protein that may be component of regulatory network that controls ray development and function. (568 aa)
shk-1Potassium voltage-gated channel protein shk-1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d. (536 aa)
gbb-2Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (842 aa)
gpb-1Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa)
shw-1BTB domain-containing protein; Belongs to the potassium channel family. (619 aa)
egl-2Uncharacterized protein. (959 aa)
twk-6TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (347 aa)
twk-23TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (443 aa)
twk-11TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (1720 aa)
twk-1TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (451 aa)
twk-7TWiK family of potassium channels protein 7. (557 aa)
twk-12TWiK family of potassium channels protein 12. (684 aa)
twk-35TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (557 aa)
twk-43TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (597 aa)
twk-47Ion_trans_2 domain-containing protein. (500 aa)
F35A5.4Uncharacterized protein. (524 aa)
twk-30TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (608 aa)
kvs-3Uncharacterized protein; Belongs to the potassium channel family. (451 aa)
twk-29TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (476 aa)
gpb-2Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa)
twk-16TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (555 aa)
twk-32TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (614 aa)
twk-36TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (562 aa)
egl-36Potassium voltage-gated channel protein egl-36; Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily. (558 aa)
twk-49Ion_trans_2 domain-containing protein. (337 aa)
twk-13TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (625 aa)
irk-1Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa)
kqt-2Ion_trans domain-containing protein; Belongs to the potassium channel family. (695 aa)
twk-3TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (383 aa)
twk-25TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (683 aa)
irk-2Inward Rectifying K (Potassium) channel family. (497 aa)
twk-48TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (372 aa)
twk-34TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (558 aa)
twk-10TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (429 aa)
gpc-1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
K01H12.4Uncharacterized protein. (329 aa)
kcnl-3Small conductance calcium-activated potassium channel-like protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium. (692 aa)
B0310.1Uncharacterized protein B0310.1. (292 aa)
twk-24TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (579 aa)
twk-5TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (288 aa)
kcnl-1CaMBD domain-containing protein. (792 aa)
C32C4.1BTB domain-containing protein; Belongs to the potassium channel family. (575 aa)
twk-26TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (519 aa)
twk-37TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (382 aa)
twk-28TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (523 aa)
kcnl-4CaMBD domain-containing protein. (485 aa)
kvs-1Uncharacterized protein; Belongs to the potassium channel family. (495 aa)
kcnl-2CaMBD domain-containing protein. (855 aa)
gpc-2G protein gamma domain-containing protein. (62 aa)
exp-2Uncharacterized protein; Belongs to the potassium channel family. (510 aa)
unc-103Potassium voltage-gated channel unc-103; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior ; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (898 aa)
C27F2.6Uncharacterized protein. (165 aa)
kqt-1Potassium channel, KvQLT family; Belongs to the potassium channel family. (740 aa)
twk-39TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (676 aa)
twk-18TWiK family of potassium channels protein 18; Outwardly rectifying potassium channel protein; activity is sharply augmented by increase in temperature. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (461 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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