(23 nodes) Integration of energy metabolism network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	pks-1	PolyKetide Synthase. (7752 aa)
	paqr-1	Progestin and adipoQ receptor-like protein 1; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family. (440 aa)
	acs-17	Fatty Acid CoA Synthetase family. (718 aa)
	tkt-1	Transket_pyr domain-containing protein. (618 aa)
	gpc-2	G protein gamma domain-containing protein. (62 aa)
	gpb-1	Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa)
	fasn-1	Carrier domain-containing protein. (2613 aa)
	F32H2.6	Ketoacyl_synth_N domain-containing protein. (187 aa)
	itr-1	Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa)
	acs-4	Fatty Acid CoA Synthetase family. (731 aa)
	mxl-2	BHLH domain-containing protein. (205 aa)
	F47F2.1	cAMP-dependent protein kinase, catalytic subunit-like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily. (398 aa)
	gpb-2	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa)
	gpc-1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
	egl-30	Heterotrimeric G protein alpha subunit. (355 aa)
	kin-2	cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. (376 aa)
	mml-1	Protein WBSCR14 homolog; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3' (By similarity). (1009 aa)
	epac-1	Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1. (1038 aa)
	T28F3.5	Uncharacterized protein. (1612 aa)
	pod-2	Uncharacterized protein. (2165 aa)
	tald-1	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (319 aa)
	paqr-2	Progestin and AdipoQ Receptor family. (581 aa)
	kin-1	cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F32H2.6	T28F3.5	F32H2.6.1	T28F3.5a.1	Ketoacyl_synth_N domain-containing protein.	Uncharacterized protein.	0.577
F32H2.6	pks-1	F32H2.6.1	C41A3.1a.1	Ketoacyl_synth_N domain-containing protein.	PolyKetide Synthase.	0.909
F32H2.6	pod-2	F32H2.6.1	W09B6.1c.1	Ketoacyl_synth_N domain-containing protein.	Uncharacterized protein.	0.577
F32H2.6	tkt-1	F32H2.6.1	F01G10.1.2	Ketoacyl_synth_N domain-containing protein.	Transket_pyr domain-containing protein.	0.406
F47F2.1	gpb-2	F47F2.1b.1	F52A8.2a.1	cAMP-dependent protein kinase, catalytic subunit-like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.403
F47F2.1	kin-1	F47F2.1b.1	ZK909.2n.2	cAMP-dependent protein kinase, catalytic subunit-like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.	cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	0.607
F47F2.1	kin-2	F47F2.1b.1	R07E4.6c.1	cAMP-dependent protein kinase, catalytic subunit-like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.	cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family.	0.999
T28F3.5	F32H2.6	T28F3.5a.1	F32H2.6.1	Uncharacterized protein.	Ketoacyl_synth_N domain-containing protein.	0.577
T28F3.5	acs-17	T28F3.5a.1	C46F4.2.2	Uncharacterized protein.	Fatty Acid CoA Synthetase family.	0.439
T28F3.5	acs-4	T28F3.5a.1	F37C12.7.1	Uncharacterized protein.	Fatty Acid CoA Synthetase family.	0.432
T28F3.5	fasn-1	T28F3.5a.1	F32H2.5.1	Uncharacterized protein.	Carrier domain-containing protein.	0.717
T28F3.5	mml-1	T28F3.5a.1	T20B12.6a.1	Uncharacterized protein.	Protein WBSCR14 homolog; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3' (By similarity).	0.400
T28F3.5	pks-1	T28F3.5a.1	C41A3.1a.1	Uncharacterized protein.	PolyKetide Synthase.	0.842
T28F3.5	pod-2	T28F3.5a.1	W09B6.1c.1	Uncharacterized protein.	Uncharacterized protein.	0.830
T28F3.5	tkt-1	T28F3.5a.1	F01G10.1.2	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.498
acs-17	T28F3.5	C46F4.2.2	T28F3.5a.1	Fatty Acid CoA Synthetase family.	Uncharacterized protein.	0.439
acs-17	acs-4	C46F4.2.2	F37C12.7.1	Fatty Acid CoA Synthetase family.	Fatty Acid CoA Synthetase family.	0.760
acs-17	fasn-1	C46F4.2.2	F32H2.5.1	Fatty Acid CoA Synthetase family.	Carrier domain-containing protein.	0.950
acs-17	pks-1	C46F4.2.2	C41A3.1a.1	Fatty Acid CoA Synthetase family.	PolyKetide Synthase.	0.699
acs-17	pod-2	C46F4.2.2	W09B6.1c.1	Fatty Acid CoA Synthetase family.	Uncharacterized protein.	0.548