Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Mitogen-activated protein kinase 15; Atypical MAPK protein. Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance. Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2. Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, prob [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

RAL (Ras-related GTPase) homolog.

Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.

Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1.

Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Putative ribosomal protein S6 kinase alpha-1; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

Uncharacterized protein.

Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...]

Uncharacterized protein.

Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...]

Uncharacterized protein.

Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.

Uncharacterized protein.

Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).

Uncharacterized protein.

Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...]

Uncharacterized protein.

SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...]

AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.

AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.

AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.

AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...]

AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.

Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...]