STRINGSTRING
tag-52 tag-52 tiam-1 tiam-1 cgef-1 cgef-1 exc-5 exc-5 vav-1 vav-1 rhgf-1 rhgf-1 unc-73 unc-73 ephx-1 ephx-1 pix-1 pix-1 osg-1 osg-1 ect-2 ect-2 sos-1 sos-1 itsn-1 itsn-1 Y73E7A.2 Y73E7A.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tag-52Putative protein tag-52. (665 aa)
tiam-1DH domain-containing protein. (889 aa)
cgef-1DH domain-containing protein. (1055 aa)
exc-5Uncharacterized protein. (861 aa)
vav-1Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa)
rhgf-1RHo Guanine nucleotide exchange Factor. (1340 aa)
unc-73Guanine nucleotide exchange factor UNC-73A. (2488 aa)
ephx-1EPHeXin (Eph-interacting GEF) homolog. (1159 aa)
pix-1PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa)
osg-1Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa)
ect-2ECT2 (Mammalian Rho GEF) homolog. (932 aa)
sos-1Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa)
itsn-1ITSN (Intersectin) family. (1087 aa)
Y73E7A.2Uncharacterized protein. (463 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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