STRINGSTRING
his-22 his-22 leo-1 leo-1 his-48 his-48 his-46 his-46 zipt-13 zipt-13 ruvb-1 ruvb-1 C29F9.5 C29F9.5 C29F9.6 C29F9.6 trr-1 trr-1 C49F5.5 C49F5.5 his-41 his-41 his-37 his-37 his-54 his-54 his-52 his-52 his-50 his-50 his-44 his-44 his-31 his-31 his-34 his-34 rbbp-5 rbbp-5 his-64 his-64 F22F1.3 F22F1.3 srh-255 srh-255 srh-266 srh-266 cdc-73 cdc-73 his-29 his-29 cbp-3 cbp-3 his-8 his-8 his-39 his-39 his-5 his-5 his-56 his-56 his-58 his-58 his-60 his-60 his-62 his-62 his-66 his-66 his-38 his-38 cbp-2 cbp-2 his-18 his-18 his-28 his-28 his-20 his-20 cbp-1 cbp-1 srh-257 srh-257 srh-258 srh-258 srh-264 srh-264 srh-265 srh-265 his-4 his-4 his-1 his-1 his-67 his-67 unc-37 unc-37 pop-1 pop-1 ash-2 ash-2 ZK1010.10 ZK1010.10 his-26 his-26 his-10 his-10 his-11 his-11 his-14 his-14 his-15 his-15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-22Histone H2B 2. (123 aa)
leo-1RNA polymerase-associated protein LEO1; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification. (430 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
zipt-13Zrt (ZRT), Irt-(IRT-) like Protein Transporter. (353 aa)
ruvb-1RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce- Tor signaling pathway whereby it i [...] (476 aa)
C29F9.5Uncharacterized protein. (261 aa)
C29F9.6TAZ-type domain-containing protein. (240 aa)
trr-1Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. (4064 aa)
C49F5.5TAZ-type domain-containing protein. (151 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-37Histone H4. (103 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-52Histone H2B 2. (123 aa)
his-50Histone H4. (103 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
his-31Histone H4. (103 aa)
his-34Histone H2B 1. (122 aa)
rbbp-5Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. (454 aa)
his-64Histone H4. (103 aa)
F22F1.3Uncharacterized protein. (245 aa)
srh-255Serpentine Receptor, class H. (329 aa)
srh-266Serpentine Receptor, class H. (327 aa)
cdc-73Cell division cycle protein 73; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification; Belongs to the CDC73 family. (517 aa)
his-29Histone H2B 1. (122 aa)
cbp-3TAZ-type domain-containing protein. (199 aa)
his-8Histone H2B 2. (123 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
his-5Histone H4. (103 aa)
his-56Histone H4. (103 aa)
his-58Probable histone H2B 4. (123 aa)
his-60Histone H4. (103 aa)
his-62Probable histone H2B 4. (123 aa)
his-66Probable histone H2B 4. (123 aa)
his-38Histone H4. (103 aa)
cbp-2CBP/p300 homolog. (322 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
his-20Histone H2B 2. (123 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
srh-257Serpentine Receptor, class H. (329 aa)
srh-258Serpentine Receptor, class H. (334 aa)
srh-264Serpentine Receptor, class H. (333 aa)
srh-265Serpentine Receptor, class H. (334 aa)
his-4Histone H2B 2. (123 aa)
his-1Histone H4. (103 aa)
his-67Histone H4. (103 aa)
unc-37Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. (612 aa)
pop-1Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa)
ash-2Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (575 aa)
ZK1010.10TAZ-type domain-containing protein. (194 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-11Histone H2B 1. (122 aa)
his-14Histone H4. (103 aa)
his-15Histone H2B 1. (122 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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