STRINGSTRING
sel-12 sel-12 ubq-1 ubq-1 F52C6.2 F52C6.2 rhgf-1 rhgf-1 aph-2 aph-2 Y73E7A.2 Y73E7A.2 sqst-4 sqst-4 itsn-1 itsn-1 aph-1 aph-1 sos-1 sos-1 pen-2 pen-2 sqst-3 sqst-3 ect-2 ect-2 osg-1 osg-1 pix-1 pix-1 ephx-1 ephx-1 unc-73 unc-73 F52C6.3 F52C6.3 vav-1 vav-1 exc-5 exc-5 hop-1 hop-1 cgef-1 cgef-1 tiam-1 tiam-1 tag-52 tag-52
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
rhgf-1RHo Guanine nucleotide exchange Factor. (1340 aa)
aph-2Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (723 aa)
Y73E7A.2Uncharacterized protein. (463 aa)
sqst-4ZZ-type domain-containing protein. (177 aa)
itsn-1ITSN (Intersectin) family. (1087 aa)
aph-1Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. (308 aa)
sos-1Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa)
pen-2Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family. (101 aa)
sqst-3ZZ-type domain-containing protein. (229 aa)
ect-2ECT2 (Mammalian Rho GEF) homolog. (932 aa)
osg-1Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa)
pix-1PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa)
ephx-1EPHeXin (Eph-interacting GEF) homolog. (1159 aa)
unc-73Guanine nucleotide exchange factor UNC-73A. (2488 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
vav-1Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa)
exc-5Uncharacterized protein. (861 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
cgef-1DH domain-containing protein. (1055 aa)
tiam-1DH domain-containing protein. (889 aa)
tag-52Putative protein tag-52. (665 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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