STRINGSTRING
his-48 his-48 his-46 his-46 mpk-2 mpk-2 apc-17 apc-17 kxd-1 kxd-1 ceh-31 ceh-31 ceh-30 ceh-30 set-32 set-32 set-6 set-6 his-41 his-41 his-37 his-37 his-54 his-54 his-52 his-52 his-50 his-50 F08F1.9 F08F1.9 his-44 his-44 F09C12.2 F09C12.2 emb-27 emb-27 mat-3 mat-3 apc-10 apc-10 ceh-1 ceh-1 his-31 his-31 his-34 his-34 ceh-19 ceh-19 his-64 his-64 ubq-1 ubq-1 set-11 set-11 F34H10.1 F34H10.1 apc-11 apc-11 his-29 his-29 mig-38 mig-38 mpk-1 mpk-1 his-8 his-8 his-39 his-39 his-5 his-5 F52C6.2 F52C6.2 F52C6.3 F52C6.3 emb-30 emb-30 his-56 his-56 his-58 his-58 his-60 his-60 his-62 his-62 cya-2 cya-2 his-66 his-66 ubl-1 ubl-1 his-38 his-38 his-18 his-18 his-22 his-22 his-28 his-28 his-20 his-20 apc-2 apc-2 K08C9.7 K08C9.7 set-13 set-13 gfi-3 gfi-3 set-15 set-15 rskn-1 rskn-1 cki-1 cki-1 cki-2 cki-2 his-4 his-4 his-1 his-1 his-67 his-67 set-19 set-19 set-20 set-20 W02D3.12 W02D3.12 W05G11.2 W05G11.2 mat-2 mat-2 Y104H12D.2 Y104H12D.2 Y104H12D.4 Y104H12D.4 set-33 set-33 mat-1 mat-1 set-21 set-21 Y41D4B.4 Y41D4B.4 Y48G1C.12 Y48G1C.12 such-1 such-1 ubq-2 ubq-2 his-26 his-26 his-10 his-10 his-11 his-11 his-14 his-14 his-15 his-15 cya-1 cya-1 ZK678.3 ZK678.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
mpk-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (605 aa)
apc-17Anaphase Promoting Complex see also mat. (325 aa)
kxd-1KxDL domain-containing protein. (140 aa)
ceh-31Homeobox protein ceh-31. (260 aa)
ceh-30Homeobox protein ceh-30; Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway. (237 aa)
set-32SET domain-containing protein. (517 aa)
set-6SET domain-containing protein. (708 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-37Histone H4. (103 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-52Histone H2B 2. (123 aa)
his-50Histone H4. (103 aa)
F08F1.9CYCLIN domain-containing protein; Belongs to the cyclin family. (130 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
F09C12.2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (418 aa)
emb-27Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (655 aa)
mat-3Cell division cycle protein 23 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptor [...] (673 aa)
apc-10Anaphase-promoting complex subunit 10; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. (212 aa)
ceh-1Homeobox protein ceh-1. (171 aa)
his-31Histone H4. (103 aa)
his-34Histone H2B 1. (122 aa)
ceh-19Homeobox protein ceh-19. (199 aa)
his-64Histone H4. (103 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
set-11SET (Trithorax/polycomb) domain containing. (367 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
apc-11Anaphase-promoting complex subunit 11; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity. Belongs to the RING-box family. (135 aa)
his-29Histone H2B 1. (122 aa)
mig-38Abnormal cell migration protein 38; During gonad development, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody which allows for the formation of gonad arms. Role in gonad DTC migration may be in association with integrin related proteins ina-1 and mig-15. (1607 aa)
mpk-1Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa)
his-8Histone H2B 2. (123 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
his-5Histone H4. (103 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
emb-30Abnormal embryogenesis protein 30; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells. Required for embryonic anterior- posterior axis formation. Negatively regulat [...] (1027 aa)
his-56Histone H4. (103 aa)
his-58Probable histone H2B 4. (123 aa)
his-60Histone H4. (103 aa)
his-62Probable histone H2B 4. (123 aa)
cya-2CYCLIN domain-containing protein; Belongs to the cyclin family. (123 aa)
his-66Probable histone H2B 4. (123 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-22Histone H2B 2. (123 aa)
his-28Histone H4. (103 aa)
his-20Histone H2B 2. (123 aa)
apc-2Anaphase-promoting complex subunit 2; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. (731 aa)
K08C9.7Uncharacterized protein. (154 aa)
set-13SET domain-containing protein. (402 aa)
gfi-3Protein gfi-3; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis. (800 aa)
set-15SET domain-containing protein. (611 aa)
rskn-1Putative ribosomal protein S6 kinase alpha-1; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (804 aa)
cki-1Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family. (184 aa)
cki-2CKI family (Cyclin-dependent Kinase Inhibitor). (259 aa)
his-4Histone H2B 2. (123 aa)
his-1Histone H4. (103 aa)
his-67Histone H4. (103 aa)
set-19SET domain-containing protein. (944 aa)
set-20SET (Trithorax/polycomb) domain containing. (552 aa)
W02D3.12Uncharacterized protein. (89 aa)
W05G11.2Cyclin N-terminal domain-containing protein. (192 aa)
mat-2Anaphase-promoting complex subunit 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors [...] (1505 aa)
Y104H12D.2Uncharacterized protein. (327 aa)
Y104H12D.4Uncharacterized protein. (107 aa)
set-33SET (Trithorax/polycomb) domain containing. (551 aa)
mat-1Cell division cycle protein 27 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (788 aa)
set-21SET domain-containing protein. (568 aa)
Y41D4B.4Uncharacterized protein. (656 aa)
Y48G1C.12DOC domain-containing protein. (216 aa)
such-1Suppressor of spindle checkpoint defect 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis. Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells. Belongs to the APC5 family. (798 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-11Histone H2B 1. (122 aa)
his-14Histone H4. (103 aa)
his-15Histone H2B 1. (122 aa)
cya-1G2/mitotic-specific cyclin-A1; Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis. Belongs to the cyclin family. Cyclin AB subfamily. (485 aa)
ZK678.3annotation not available (163 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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