STRINGSTRING
lap-1 lap-1 dnc-1 dnc-1 F16B12.5 F16B12.5 sas-4 sas-4 E02H4.6 E02H4.6 cul-1 cul-1 skr-8 skr-8 skr-13 skr-13 skr-9 skr-9 skr-12 skr-12 skr-16 skr-16 dnc-2 dnc-2 mel-11 mel-11 skr-17 skr-17 madf-11 madf-11 skr-18 skr-18 ubl-1 ubl-1 cyb-2.2 cyb-2.2 gfi-2 gfi-2 K08C9.7 K08C9.7 cul-6 cul-6 skr-21 skr-21 lin-23 lin-23 skr-19 skr-19 skr-20 skr-20 lis-1 lis-1 T04F8.6 T04F8.6 cyb-3 cyb-3 T08D2.8 T08D2.8 ebp-2 ebp-2 lap-2 lap-2 skr-10 skr-10 skr-6 skr-6 cyb-2.1 cyb-2.1 skr-7 skr-7 skr-14 skr-14 ccep-290 ccep-290 Y57G11C.5 Y57G11C.5 ebp-1 ebp-1 ebp-3 ebp-3 skr-4 skr-4 Y73F8A.20 Y73F8A.20 cyb-1 cyb-1 zyg-9 zyg-9 F22H10.1 F22H10.1 ubq-1 ubq-1 hum-1 hum-1 F34H10.1 F34H10.1 skr-3 skr-3 skr-2 skr-2 skr-1 skr-1 kin-20 kin-20 skr-5 skr-5 F52C6.2 F52C6.2 F52C6.3 F52C6.3 F54A3.2 F54A3.2 skr-15 skr-15 ZC373.3 ZC373.3 ubq-2 ubq-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lap-1Leucine aminopeptidase 1; Probably acts as a digestive enzyme. (491 aa)
dnc-1CAP-Gly domain-containing protein. (1351 aa)
F16B12.5annotation not available (227 aa)
sas-4Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. (808 aa)
E02H4.6Protein kinase domain-containing protein. (303 aa)
cul-1Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)
skr-8SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-13SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-9SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-12SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-16SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa)
dnc-2Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. (331 aa)
mel-11ANK_REP_REGION domain-containing protein. (1124 aa)
skr-17SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa)
madf-11MADF domain-containing protein. (516 aa)
skr-18Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
cyb-2.2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa)
gfi-2ANK_REP_REGION domain-containing protein. (480 aa)
K08C9.7Uncharacterized protein. (154 aa)
cul-6Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa)
skr-21Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa)
lin-23F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). (667 aa)
skr-19Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa)
skr-20SKp1 Related (Ubiquitin ligase complex component). (173 aa)
lis-1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa)
T04F8.6Uncharacterized protein. (794 aa)
cyb-3G2/mitotic-specific cyclin-B3; Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II. (385 aa)
T08D2.8TOG domain-containing protein. (388 aa)
ebp-2Microtubule End Binding Protein. (299 aa)
lap-2Putative aminopeptidase W07G4.4. (522 aa)
skr-10SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa)
skr-6SKp1 Related (Ubiquitin ligase complex component). (106 aa)
cyb-2.1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa)
skr-7SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-14SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa)
ccep-290CEntrosomal Protein. (1736 aa)
Y57G11C.5SERPIN domain-containing protein. (535 aa)
ebp-1Microtubule End Binding Protein. (316 aa)
ebp-3EB1 C-terminal domain-containing protein. (187 aa)
skr-4SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa)
Y73F8A.20Uncharacterized protein. (541 aa)
cyb-1G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (361 aa)
zyg-9Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. (1415 aa)
F22H10.1Protein kinase domain-containing protein. (207 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
hum-1Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1100 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
skr-3SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa)
skr-2SKp1 Related (Ubiquitin ligase complex component). (174 aa)
skr-1Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa)
kin-20Casein kinase I isoform delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Is a developmental timer that specifies temporal cell fate selection; acts to control the temporal identity of hypodermal seam cells. Required during late-larval development to prevent adult fates, particularly cell cycle exit and fusion, from being expressed too early. (497 aa)
skr-5SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
F54A3.2Uncharacterized protein. (748 aa)
skr-15SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa)
ZC373.3Protein kinase domain-containing protein. (321 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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