STRINGSTRING
acd-4 acd-4 del-10 del-10 del-4 del-4 clh-1 clh-1 best-19 best-19 best-18 best-18 best-17 best-17 T19B10.2 T19B10.2 T18D3.7 T18D3.7 T13G4.1 T13G4.1 ocr-3 ocr-3 ocr-2 ocr-2 clh-4 clh-4 gon-2 gon-2 mec-4 mec-4 R144.11 R144.11 cup-5 cup-5 best-16 best-16 unc-8 unc-8 best-15 best-15 sao-1 sao-1 clh-6 clh-6 trp-2 trp-2 K11H3.8 K11H3.8 unc-68 unc-68 K09A9.6 K09A9.6 K08C9.7 K08C9.7 unc-1 unc-1 mbl-1 mbl-1 spe-41 spe-41 H17B01.2 H17B01.2 ubl-1 ubl-1 del-5 del-5 F58G6.8 F58G6.8 unc-24 unc-24 F57G8.5 F57G8.5 anoh-1 anoh-1 egas-4 egas-4 gtl-2 gtl-2 ttyh-1 ttyh-1 cup-15 cup-15 F41E7.2 F41E7.2 F41E7.1 F41E7.1 F41E6.11 F41E6.11 csq-1 csq-1 F37C4.8 F37C4.8 F34H10.1 F34H10.1 F33G12.6 F33G12.6 best-14 best-14 best-13 best-13 sto-2 sto-2 ocr-1 ocr-1 degt-1 degt-1 unc-80 unc-80 delm-1 delm-1 F17C8.6 F17C8.6 mec-10 mec-10 best-12 best-12 mec-2 mec-2 pqn-29 pqn-29 sto-1 sto-1 flr-1 flr-1 clh-3 clh-3 unc-79 unc-79 del-1 del-1 C56G2.5 C56G2.5 best-11 best-11 best-10 best-10 deg-1 deg-1 wnk-1 wnk-1 best-9 best-9 unc-105 unc-105 best-8 best-8 C30G4.4 C30G4.4 best-7 best-7 trpa-1 trpa-1 nca-2 nca-2 acd-3 acd-3 acd-2 acd-2 acd-1 acd-1 delm-2 delm-2 C18H9.3 C18H9.3 del-9 del-9 kxd-1 kxd-1 unc-77 unc-77 C09B9.85 C09B9.85 best-6 best-6 clh-5 clh-5 best-5 best-5 C06E2.1 C06E2.1 gtl-1 gtl-1 best-4 best-4 best-3 best-3 best-2 best-2 best-1 best-1 clh-2 clh-2 osm-9 osm-9 best-26 best-26 best-25 best-25 asic-1 asic-1 best-24 best-24 best-23 best-23 ced-11 ced-11 ubq-2 ubq-2 best-22 best-22 trp-1 trp-1 best-21 best-21 sto-4 sto-4 sto-6 sto-6 cosa-1 cosa-1 egas-3 egas-3 egas-2 egas-2 egas-1 egas-1 Y57G11C.44 Y57G11C.44 anoh-2 anoh-2 Y53G8AR.9 Y53G8AR.9 Y51H7C.13 Y51H7C.13 Y51H7C.1 Y51H7C.1 Y48C3A.12 Y48C3A.12 Y47D7A.11 Y47D7A.11 Y45F10B.13 Y45F10B.13 ocr-4 ocr-4 best-20 best-20 exc-4 exc-4 sgk-1 sgk-1 tag-229 tag-229 asic-2 asic-2 acd-5 acd-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acd-4Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (613 aa)
del-10Degenerin-like protein del-10. (1069 aa)
del-4DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (527 aa)
clh-1Chloride channel protein. (906 aa)
best-19Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (569 aa)
best-18Bestrophin homolog 18; Forms chloride channels. (456 aa)
best-17Bestrophin homolog 17; Forms chloride channels. (501 aa)
T19B10.2Uncharacterized protein. (368 aa)
T18D3.7Uncharacterized protein T18D3.7; Belongs to the TSC-22/Dip/Bun family. (269 aa)
T13G4.1GYF domain-containing protein. (163 aa)
ocr-3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (818 aa)
ocr-2ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (900 aa)
clh-4Chloride channel protein. (1085 aa)
gon-2Transient receptor potential channel; Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2032 aa)
mec-4Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (768 aa)
R144.11Uncharacterized protein. (307 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
best-16Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (463 aa)
unc-8Degenerin unc-8. (778 aa)
best-15Bestrophin homolog 15; Forms chloride channels. (525 aa)
sao-1Suppressor of aph-1; Involved in negative regulation of early and late embryonic Notch signaling. (245 aa)
clh-6Chloride channel protein. (796 aa)
trp-2TRP (Transient receptor potential) channel family; Belongs to the transient receptor (TC 1.A.4) family. (886 aa)
K11H3.8GYF domain-containing protein. (355 aa)
unc-68Uncharacterized protein. (5202 aa)
K09A9.6TPR_REGION domain-containing protein. (920 aa)
K08C9.7Uncharacterized protein. (154 aa)
unc-1Protein unc-1. (289 aa)
mbl-1Muscleblind-like protein; Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'. (324 aa)
spe-41TRP homologous cation channel protein. (854 aa)
H17B01.2Uncharacterized protein. (466 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
del-5DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
F58G6.8Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (198 aa)
unc-24PHB domain-containing protein. (443 aa)
F57G8.5Na_H_Exchanger domain-containing protein. (498 aa)
anoh-1Anoctamin. (840 aa)
egas-4EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (883 aa)
gtl-2Gon-Two Like (TRP subfamily). (1406 aa)
ttyh-1Protein tweety homolog 1; Probable chloride channel. (519 aa)
cup-15Coelomocyte uptake defective protein 15; Modulates the transport of substances from the endosomal to lysosomal compartments. Plays a role in lysosome formation and function in coelomocytes. (322 aa)
F41E7.2Na_H_Exchanger domain-containing protein. (558 aa)
F41E7.1Na_H_Exchanger domain-containing protein. (516 aa)
F41E6.11Uncharacterized protein. (316 aa)
csq-1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (417 aa)
F37C4.8Uncharacterized protein. (343 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
F33G12.6PPM-type phosphatase domain-containing protein. (771 aa)
best-14Bestrophin homolog 14. (405 aa)
best-13Bestrophin homolog 13; Forms chloride channels. (413 aa)
sto-2Stomatin-2; May be involved in cilia-related function. (375 aa)
ocr-1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
degt-1DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (852 aa)
unc-80Protein unc-80; Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane. (3263 aa)
delm-1DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (626 aa)
F17C8.6Uncharacterized protein. (279 aa)
mec-10Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (724 aa)
best-12Bestrophin homolog 12; Forms chloride channels. (434 aa)
mec-2Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons. (1239 aa)
pqn-29Prion-like-(Q/N-rich)-domain-bearing protein. (549 aa)
sto-1Stomatin-1. (330 aa)
flr-1FLR-1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (638 aa)
clh-3Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...] (1091 aa)
unc-79Uncoordinated protein 79. (2092 aa)
del-1Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (694 aa)
C56G2.5Non-specific serine/threonine protein kinase. (713 aa)
best-11Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (444 aa)
best-10Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (423 aa)
deg-1Degenerin deg-1; Probable sodium channel subunit. Required by a subset of neurons. (778 aa)
wnk-1Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals. (1850 aa)
best-9Bestrophin homolog 9; Forms chloride channels. (399 aa)
unc-105Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (962 aa)
best-8Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (512 aa)
C30G4.4Uncharacterized protein. (357 aa)
best-7Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (540 aa)
trpa-1Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. (1211 aa)
nca-2Four domain-type voltage-gated ion channel alpha-1 subunit. (1785 aa)
acd-3Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (484 aa)
acd-2Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (693 aa)
acd-1Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (635 aa)
delm-2DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (608 aa)
C18H9.3GYF domain-containing protein gyf-1. (1106 aa)
del-9DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (579 aa)
kxd-1KxDL domain-containing protein. (140 aa)
unc-77Uncharacterized protein. (1867 aa)
C09B9.85Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (555 aa)
best-6Bestrophin-6. (382 aa)
clh-5Chloride channel protein. (797 aa)
best-5Bestrophin homolog 5; Forms chloride channels. (453 aa)
C06E2.1Uncharacterized protein. (281 aa)
gtl-1LSDAT_euk domain-containing protein. (1694 aa)
best-4Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (558 aa)
best-3Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (612 aa)
best-2Bestrophin homolog 2; Forms chloride channels. (421 aa)
best-1Bestrophin homolog 1; Forms chloride channels. (450 aa)
clh-2Chloride channel protein. (880 aa)
osm-9ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (937 aa)
best-26Bestrophin homolog 26; Forms chloride channels. (411 aa)
best-25Bestrophin homolog 25; Forms chloride channels. (602 aa)
asic-1Degenerin-like protein asic-1; Proton-gated cation channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions (By similarity). (823 aa)
best-24Bestrophin homolog 24; Forms chloride channels. (632 aa)
best-23Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (405 aa)
ced-11Protein ced-11; Plays a major role in programmed cell death. (1418 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
best-22Bestrophin homolog 22; Forms chloride channels. (510 aa)
trp-1Transient-receptor-potential-like protein; Could mediate calcium entry and form a calcium permeant channel; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (1047 aa)
best-21Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (395 aa)
sto-4Stomatin-4. (281 aa)
sto-6PHB domain-containing protein. (298 aa)
cosa-1CrossOver Site Associated. (360 aa)
egas-3EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (921 aa)
egas-2EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (919 aa)
egas-1EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (938 aa)
Y57G11C.44Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (155 aa)
anoh-2Anoctamin. (893 aa)
Y53G8AR.9Uncharacterized protein. (315 aa)
Y51H7C.13Uncharacterized protein. (344 aa)
Y51H7C.1Uncharacterized protein. (448 aa)
Y48C3A.12Uncharacterized protein. (675 aa)
Y47D7A.11Uncharacterized protein. (129 aa)
Y45F10B.13Uncharacterized protein. (633 aa)
ocr-4ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (756 aa)
best-20Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (486 aa)
exc-4Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa)
sgk-1Serine/threonine-protein kinase sgk-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead- related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to pla [...] (463 aa)
tag-229YccV-like domain-containing protein. (200 aa)
asic-2Degenerin-like protein asic-2. (545 aa)
acd-5Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (714 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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