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| | npp-22 | Nucleoporin ndc-1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family. (588 aa) |
| | baf-1 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. (89 aa) |
| | C01A2.4 | Uncharacterized protein. (207 aa) |
| | npp-23 | Nuclear Pore complex Protein. (371 aa) |
| | spas-1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. (512 aa) |
| | ran-3 | Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. (569 aa) |
| | ran-2 | Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate. (960 aa) |
| | npp-15 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. (1129 aa) |
| | mel-28 | Protein mel-28; Nuclear envelope protein which has essential roles in assembly of nuclear pore complexes and in chromatin maintenance during the cell cycle. Appears to be a stable structural component of the nuclear envelope during interphase. In dividing cells, localizes to kinetochores during early stages of mitosis and then to chromatin during late mitosis. Important for several mitotic processes including chromosome condensation, kinetochore assembly, chromosome segregation and cell-cycle timing. In postmitotic cells, plays a role in the early steps of nuclear pore complex assembly [...] (1784 aa) |
| | vps-32.1 | Related to yeast Vacuolar Protein Sorting factor. (221 aa) |
| | npp-5 | Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa) |
| | F14H12.3 | Uncharacterized protein. (257 aa) |
| | sur-6 | Serine/threonine-protein phosphatase 2A regulatory subunit sur-6; Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1. In addition, during vulva development, may play a role with phosphatase let-92 and regulatory subunit paa-1 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase signaling, probably by promoting lin-45 activation. In intesti [...] (495 aa) |
| | vrk-1 | Serine/threonine-protein kinase VRK1; Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of an [...] (610 aa) |
| | imb-1 | Importin N-terminal domain-containing protein. (896 aa) |
| | figl-1 | Fidgetin-like protein 1; Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility. (594 aa) |
| | spd-2 | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (824 aa) |
| | vet-6 | Very Early Transcript. (843 aa) |
| | npp-6 | Nuclear Pore complex Protein. (1562 aa) |
| | cyb-2.2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa) |
| | ran-1 | GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. (215 aa) |
| | istr-1 | Increased Sodium Tolerance Related. (445 aa) |
| | smo-1 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa) |
| | npp-3 | Nuclear Pore complex Protein. (1696 aa) |
| | npp-19 | Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase. (381 aa) |
| | R12C12.5 | Uncharacterized protein. (236 aa) |
| | npp-2 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (598 aa) |
| | T04D3.1 | Uncharacterized protein. (454 aa) |
| | cyb-3 | G2/mitotic-specific cyclin-B3; Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II. (385 aa) |
| | npp-7 | Nuclear Pore complex Protein. (1217 aa) |
| | T24B8.2 | Charged Multivesicular Body Protein homolog. (411 aa) |
| | vps-24 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | lem-2 | LEM protein 2; Essential protein involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with emr-1. May play a role in radiation-induced DNA damage repair response. (500 aa) |
| | W02B12.13 | Uncharacterized protein. (262 aa) |
| | npp-13 | Nuclear pore protein. (787 aa) |
| | Y37H9A.3 | Coiled-coil and C2 domain-containing protein 1-like; Belongs to the CC2D1 family. (792 aa) |
| | npp-8 | Nuclear Pore complex Protein. (1340 aa) |
| | cyb-2.1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa) |
| | npp-18 | Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus. (363 aa) |
| | vps-2 | Related to yeast Vacuolar Protein Sorting factor. (237 aa) |
| | npp-4 | Nuclear Pore complex Protein. (538 aa) |
| | lem-4 | Ankyrin repeat and LEM domain-containing protein 2 homolog; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. (603 aa) |
| | vps-20 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | npp-20 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa) |
| | cyb-1 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (361 aa) |
| | ZK1053.4 | Uncharacterized protein. (701 aa) |
| | npp-10 | Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...] (1678 aa) |
