STRINGSTRING
npp-22 npp-22 npp-14 npp-14 npp-23 npp-23 hsp-70 hsp-70 hsp-3 hsp-3 npp-15 npp-15 hsp-110 hsp-110 gska-3 gska-3 hsp-6 hsp-6 C44H4.6 C44H4.6 npp-5 npp-5 rae-1 rae-1 F11F1.1 F11F1.1 rpa-1 rpa-1 F21F3.2 F21F3.2 hsp-1 hsp-1 dnj-11 dnj-11 F42A6.6 F42A6.6 hsp-4 hsp-4 F44E5.4 F44E5.4 F44E5.5 F44E5.5 vet-6 vet-6 stc-1 stc-1 npp-6 npp-6 bag-1 bag-1 unc-23 unc-23 sdz-24 sdz-24 K07F5.12 K07F5.12 npp-1 npp-1 npp-3 npp-3 R03D7.5 R03D7.5 R03H10.6 R03H10.6 R03H10.7 R03H10.7 npp-19 npp-19 sir-2.1 sir-2.1 npp-2 npp-2 T04D3.1 T04D3.1 hip-1 hip-1 npp-7 npp-7 npp-12 npp-12 W02B12.13 W02B12.13 dnj-24 dnj-24 Y106G6D.4 Y106G6D.4 Y106G6E.1 Y106G6E.1 gsk-3 gsk-3 npp-13 npp-13 npp-8 npp-8 npp-18 npp-18 hsf-1 hsf-1 npp-4 npp-4 npp-16 npp-16 npp-20 npp-20 gcy-15 gcy-15 ZK1053.4 ZK1053.4 npp-24 npp-24 npp-10 npp-10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
npp-22Nucleoporin ndc-1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family. (588 aa)
npp-14Nuclear pore complex protein 14; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4. (1390 aa)
npp-23Nuclear Pore complex Protein. (371 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
npp-15Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. (1129 aa)
hsp-110Heat shock protein 110. (776 aa)
gska-3Protein kinase domain-containing protein. (381 aa)
hsp-6Heat shock 70 kDa protein F, mitochondrial; Belongs to the heat shock protein 70 family. (657 aa)
C44H4.6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (367 aa)
npp-5Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa)
rae-1mRNA export factor rae-1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). It is specifically important for nuclear mRNA export. Has a role in neuronal development, where it acts downstream of rpm-1 to control axon termination and synapse formation in anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) mechanosensory neurons. Belo [...] (373 aa)
F11F1.1DUF148 domain-containing protein; Belongs to the heat shock protein 70 family. (607 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
F21F3.2Protein kinase domain-containing protein. (440 aa)
hsp-1Heat shock 70 kDa protein A. (640 aa)
dnj-11DNaJ domain (Prokaryotic heat shock protein). (589 aa)
F42A6.6DUF775 domain-containing protein. (219 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
F44E5.4Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa)
F44E5.5annotation not available (645 aa)
vet-6Very Early Transcript. (843 aa)
stc-1STCH (Truncated HSP) family. (450 aa)
npp-6Nuclear Pore complex Protein. (1562 aa)
bag-1BAG family molecular chaperone regulator 1; May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner. (210 aa)
unc-23BAG domain-containing protein. (458 aa)
sdz-24OB domain-containing protein. (236 aa)
K07F5.12Uncharacterized protein. (351 aa)
npp-1Nup54 domain-containing protein. (639 aa)
npp-3Nuclear Pore complex Protein. (1696 aa)
R03D7.5Putative serine/threonine-protein kinase R03D7.5; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (363 aa)
R03H10.6REPA_OB_2 domain-containing protein. (324 aa)
R03H10.7REPA_OB_2 domain-containing protein. (359 aa)
npp-19Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase. (381 aa)
sir-2.1NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] (607 aa)
npp-2Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (598 aa)
T04D3.1Uncharacterized protein. (454 aa)
hip-1TPR_REGION domain-containing protein. (422 aa)
npp-7Nuclear Pore complex Protein. (1217 aa)
npp-12Nuclear Pore complex Protein. (1847 aa)
W02B12.13Uncharacterized protein. (262 aa)
dnj-24J domain-containing protein. (249 aa)
Y106G6D.4Protein kinase domain-containing protein. (436 aa)
Y106G6E.1Protein kinase domain-containing protein. (381 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (362 aa)
npp-13Nuclear pore protein. (787 aa)
npp-8Nuclear Pore complex Protein. (1340 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus. (363 aa)
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
npp-4Nuclear Pore complex Protein. (538 aa)
npp-16Nuclear Pore complex Protein. (497 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa)
gcy-15Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1115 aa)
ZK1053.4Uncharacterized protein. (701 aa)
npp-24Protein npp-24. (655 aa)
npp-10Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...] (1678 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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