STRINGSTRING
dnj-20 dnj-20 scpl-1 scpl-1 B0432.8 B0432.8 ire-1 ire-1 C47E12.3 C47E12.3 Y24F12A.1 Y24F12A.1 crn-2 crn-2 trap-1 trap-1 Y37H2A.1 Y37H2A.1 F38A1.8 F38A1.8 T24H7.2 T24H7.2 cfp-1 cfp-1 F53E4.1 F53E4.1 yif-1 yif-1 rib-2 rib-2 K03B4.1 K03B4.1 chl-1 chl-1 R186.3 R186.3 R186.8 R186.8 xbp-1 xbp-1 T14G8.3 T14G8.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnj-20DnaJ homolog dnj-20. (355 aa)
scpl-1CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa)
B0432.8Uncharacterized protein. (259 aa)
ire-1Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa)
C47E12.3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa)
Y24F12A.1Uncharacterized protein. (437 aa)
crn-2Cell death-related nuclease 2. (286 aa)
trap-1TRanslocon-Associated Protein. (257 aa)
Y37H2A.1Uncharacterized protein. (477 aa)
F38A1.8SRP54 domain-containing protein. (625 aa)
T24H7.2Uncharacterized protein. (925 aa)
cfp-1Zf-CpG_bind_C domain-containing protein. (508 aa)
F53E4.1Uncharacterized protein. (432 aa)
yif-1YIP1-Interacting Factor homolog. (380 aa)
rib-2Exostosin-2 homolog; Glycosyltransferase required for the biosynthesis of heparan sulfate. Initiates heparan sulfate synthesis by transferring GlcNAc to the (GlcA-Gal-Gal- Xyl-)Ser core linker (GlcNAcT-I activity). In association with rib-1, is also responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (GlcNAcT-II and GlcAT-II activities). Required for normal ventral epidermal enclosure during the early stages of embryonic development. In addition, involved in the elon [...] (814 aa)
K03B4.1Uncharacterized protein. (388 aa)
chl-1ATP-dependent DNA helicase chl-1; Required for normal cell proliferation and chromosome stability. Plays a role in DNA repair during replication. Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. (830 aa)
R186.3Uncharacterized protein. (240 aa)
R186.8Uncharacterized protein. (71 aa)
xbp-1BZIP domain-containing protein. (335 aa)
T14G8.3Uncharacterized protein. (921 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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