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| | cup-2 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa) |
| | pas-7 | Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (250 aa) |
| | ZK856.5 | Metallophos domain-containing protein. (459 aa) |
| | ptr-23 | SSD domain-containing protein. (983 aa) |
| | rpn-12 | 26S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (250 aa) |
| | ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | ptr-22 | SSD domain-containing protein. (888 aa) |
| | mrp-8 | Uncharacterized protein. (1461 aa) |
| | abtm-1 | ABC Transporter, Mitochondrial. (704 aa) |
| | Y66D12A.9 | Uncharacterized protein. (248 aa) |
| | ptr-21 | SSD domain-containing protein. (909 aa) |
| | ptr-20 | SSD domain-containing protein. (860 aa) |
| | abt-5 | ABC Transporter family. (1564 aa) |
| | rpt-6 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases assoc [...] (416 aa) |
| | wht-8 | ABC transporter domain-containing protein. (619 aa) |
| | mrp-7 | Uncharacterized protein. (1525 aa) |
| | wht-7 | ABC transporter domain-containing protein. (684 aa) |
| | eif-2gamma | Tr-type G domain-containing protein. (469 aa) |
| | abt-4 | ABC Transporter family. (1802 aa) |
| | ptr-19 | SSD domain-containing protein. (1003 aa) |
| | ptr-18 | SSD domain-containing protein. (895 aa) |
| | pbs-3 | Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (204 aa) |
| | eif-2alpha | S1 motif domain-containing protein. (342 aa) |
| | ptr-17 | SSD domain-containing protein. (936 aa) |
| | pas-3 | Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (250 aa) |
| | Y105E8A.2 | Uncharacterized protein. (535 aa) |
| | hmt-1 | Heavy metal tolerance factor 1. (801 aa) |
| | T28B8.4 | Uncharacterized protein. (1874 aa) |
| | T28B8.3 | DUF3437 domain-containing protein. (1879 aa) |
| | wht-6 | ABC transporter domain-containing protein. (613 aa) |
| | rpn-1 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa) |
| | ptr-16 | SSD domain-containing protein. (898 aa) |
| | pbs-4 | Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (202 aa) |
| | ptr-15 | SSD domain-containing protein. (840 aa) |
| | rpn-9 | PCI domain-containing protein. (387 aa) |
| | pmp-4 | Peroxisomal Membrane Protein related. (734 aa) |
| | R151.6 | Derlin-2; May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins. (237 aa) |
| | rpn-8 | MPN domain-containing protein. (362 aa) |
| | ptr-14 | SSD domain-containing protein. (877 aa) |
| | mai-1 | ATPase inhibitor mai-1, mitochondrial; Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. (88 aa) |
| | pbs-1 | Proteasome subunit beta. (242 aa) |
| | K08C9.7 | Uncharacterized protein. (154 aa) |
| | rpn-11 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (312 aa) |
| | ptr-13 | SSD domain-containing protein. (851 aa) |
| | ptr-12 | SSD domain-containing protein. (901 aa) |
| | pbs-5 | Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa) |
| | cdc-48.3 | ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...] (724 aa) |
| | eif-2beta | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (250 aa) |
| | ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) |
| | rpn-6.2 | Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity). (416 aa) |
| | mrp-1 | Uncharacterized protein. (1534 aa) |
| | mrp-2 | Uncharacterized protein. (1525 aa) |
| | rpn-6.1 | Probable 26S proteasome regulatory subunit rpn-6.1; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan. (438 aa) |
| | rpt-5 | 26S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa) |
| | abt-6 | ABC Transporter family. (252 aa) |
| | F56F11.4 | AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa) |
| | ptr-11 | SSD domain-containing protein. (820 aa) |
| | ptr-10 | SSD domain-containing protein. (900 aa) |
| | ptr-9 | Patched-related protein 9; Belongs to the patched family. (844 aa) |
| | prx-19 | Putative peroxisomal biogenesis factor 19; Belongs to the peroxin-19 family. (282 aa) |
| | F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) |
| | F52C6.2 | Ubiquitin-like domain-containing protein. (228 aa) |
| | rpn-7 | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (410 aa) |
| | F48E8.4 | PRKCSH domain-containing protein. (905 aa) |
| | ptr-24 | SSD domain-containing protein. (892 aa) |
| | sel-1 | Suppressor/Enhancer of Lin-12. (685 aa) |
| | ptr-8 | SSD domain-containing protein. (890 aa) |
| | F43D9.1 | SSD domain-containing protein. (1226 aa) |
| | abcf-3 | ABC transporter, class F. (712 aa) |
| | pbs-7 | Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa) |
| | F35G12.12 | Uncharacterized protein. (491 aa) |
| | F34H10.1 | Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa) |
| | daf-6 | SSD domain-containing protein. (913 aa) |
| | F31D4.5 | Pleckstrin homology domain-containing family D member 1. (570 aa) |
| | rpt-2 | Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa) |
| | pas-5 | Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (248 aa) |
| | ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) |
| | rpt-3 | Probable 26S proteasome regulatory subunit 6B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (414 aa) |
| | rpt-4 | Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa) |
| | mrp-4 | Uncharacterized protein. (1573 aa) |
| | mrp-6 | Uncharacterized protein. (1415 aa) |
| | wht-5 | ABC transporter domain-containing protein. (695 aa) |
| | abcf-1 | ABC transporter, class F. (622 aa) |
| | mrp-5 | Uncharacterized protein. (1427 aa) |
| | abt-2 | ABC Transporter family. (2146 aa) |
| | rpn-5 | PCI domain-containing protein. (490 aa) |
| | wht-4 | ABC transporter domain-containing protein. (636 aa) |
| | mrp-3 | Uncharacterized protein. (1503 aa) |
| | pas-2 | Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (231 aa) |
| | pas-6 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa) |
| | abch-1 | ABC transporter domain-containing protein. (595 aa) |
| | abcx-1 | ABC transporter, eXtended. (710 aa) |
| | ptr-6 | SSD domain-containing protein. (982 aa) |
| | ptr-5 | SSD domain-containing protein. (961 aa) |
| | rpt-1 | 26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa) |
| | ced-7 | ABC transporter ced-7; Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells. (1758 aa) |
| | pbs-2 | Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa) |
| | ptr-4 | SSD domain-containing protein. (960 aa) |
| | pmp-2 | Peroxisomal Membrane Protein related. (661 aa) |
| | pmp-1 | Peroxisomal Membrane Protein related. (665 aa) |
| | psmd-9 | Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. (197 aa) |
| | erl-1 | Erlin. (312 aa) |
| | ptr-3 | SSD domain-containing protein. (927 aa) |
| | cdc-48.2 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa) |
| | pas-4 | Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (253 aa) |
| | ptr-2 | SSD domain-containing protein. (933 aa) |
| | rpn-3 | 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (504 aa) |
| | C26D10.6 | Uncharacterized protein. (513 aa) |
| | abt-1 | ABC transporter domain-containing protein. (1558 aa) |
| | ptr-1 | SSD domain-containing protein. (956 aa) |
| | rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa) |
| | cft-1 | Cystic Fibrosis Transmembrane conductance regulator homolog. (1247 aa) |
| | rnf-5 | E3 ubiquitin ligase rnf-5; E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the en [...] (235 aa) |
| | wht-3 | ABC transporter ATP-binding protein/permease wht-3; Required for efficient RNA interference (RNAi) of pop-1 indicating a role in the germline development. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. (614 aa) |
| | prx-3 | PeRoXisome assembly factor. (353 aa) |
| | pas-1 | Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (246 aa) |
| | C14C10.5 | Uncharacterized protein. (1908 aa) |
| | kxd-1 | KxDL domain-containing protein. (140 aa) |
| | wht-2 | ABC transporter domain-containing protein. (610 aa) |
| | cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa) |
| | wht-1 | ABC transporter ATP-binding protein/permease wht-1; Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. (671 aa) |
| | mai-2 | ATPase inhibitor mai-2, mitochondrial; Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. Activity is pH dependent. (109 aa) |
| | rpn-10 | 26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] (346 aa) |
