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| | rpn-10 | 26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] (346 aa) |
| | cam-1 | Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...] (928 aa) |
| | tax-6 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa) |
| | kxd-1 | KxDL domain-containing protein. (140 aa) |
| | C14C10.5 | Uncharacterized protein. (1908 aa) |
| | pas-1 | Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (246 aa) |
| | rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa) |
| | dsh-2 | DiSHevelled related. (759 aa) |
| | rpn-3 | 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (504 aa) |
| | dsh-1 | DiSHevelled related. (981 aa) |
| | pas-4 | Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (253 aa) |
| | psmd-9 | Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. (197 aa) |
| | pbs-2 | Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa) |
| | rpt-1 | 26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa) |
| | pas-6 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa) |
| | pas-2 | Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (231 aa) |
| | pkc-2 | Protein kinase C-like 2; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (936 aa) |
| | aps-2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa) |
| | gpc-2 | G protein gamma domain-containing protein. (62 aa) |
| | rpn-5 | PCI domain-containing protein. (490 aa) |
| | F13D12.3 | Uncharacterized protein. (245 aa) |
| | gpb-1 | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa) |
| | inft-2 | FH2 domain-containing protein. (1120 aa) |
| | rpt-4 | Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa) |
| | rpt-3 | Probable 26S proteasome regulatory subunit 6B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (414 aa) |
| | ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) |
| | pas-5 | Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (248 aa) |
| | cfz-2 | Frizzled-2; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta- catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to inv [...] (578 aa) |
| | rpt-2 | Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa) |
| | F34H10.1 | Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa) |
| | F35G12.12 | Uncharacterized protein. (491 aa) |
| | pbs-7 | Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa) |
| | rpn-7 | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (410 aa) |
| | gpb-2 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa) |
| | F52C6.2 | Ubiquitin-like domain-containing protein. (228 aa) |
| | F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) |
| | mom-4 | Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (536 aa) |
| | cnb-1 | Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] (171 aa) |
| | daam-1 | FH2 domain-containing protein. (987 aa) |
| | F56F11.4 | AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa) |
| | rpt-5 | 26S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa) |
| | rpn-6.1 | Probable 26S proteasome regulatory subunit rpn-6.1; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan. (438 aa) |
| | exc-6 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa) |
| | rpn-6.2 | Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity). (416 aa) |
| | ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) |
| | gpc-1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa) |
| | pbs-5 | Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa) |
| | rpn-11 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (312 aa) |
| | K08C9.7 | Uncharacterized protein. (154 aa) |
| | pbs-1 | Proteasome subunit beta. (242 aa) |
| | rpn-8 | MPN domain-containing protein. (362 aa) |
| | zak-1 | SAM domain-containing protein. (745 aa) |
| | dpy-23 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa) |
| | clic-1 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa) |
| | mig-5 | Segment polarity protein dishevelled homolog mig-5; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Functions redundantly with other dishevelled family members throughout development. During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells. In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the cor [...] (672 aa) |
| | rpn-9 | PCI domain-containing protein. (387 aa) |
| | apa-2 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa) |
| | pbs-4 | Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (202 aa) |
| | rpn-1 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa) |
| | mom-5 | Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...] (570 aa) |
| | T28B8.3 | DUF3437 domain-containing protein. (1879 aa) |
| | T28B8.4 | Uncharacterized protein. (1874 aa) |
| | lit-1 | Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis. (634 aa) |
| | pop-1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa) |
| | Y105C5A.24 | Protein kinase domain-containing protein. (478 aa) |
| | pas-3 | Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (250 aa) |
| | pbs-3 | Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (204 aa) |
| | rpt-6 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases assoc [...] (416 aa) |
| | Y66D12A.9 | Uncharacterized protein. (248 aa) |
| | lin-17 | Transmembrane receptor LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | sfrp-1 | NTR domain-containing protein. (314 aa) |
| | ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | rpn-12 | 26S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (250 aa) |
| | prkl-1 | Drosophila PRicKLe homolog. (523 aa) |
| | pas-7 | Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (250 aa) |
